SchaferAutismReport: Researchers Reveal First Autism Candidate Gene That Demonstrates Sensitivity to Sex Hormones

[Guest guest]

----- Forwarded Message ----To: Schafer Autism Report Sent: Thu, February 17, 2011 11:45:26 PMSubject: Researchers Reveal First Autism Candidate Gene That Demonstrates Sensitivity to Sex Hormones

Read

this report online

Large text, printer version

Thursday, February 17, 2011p

Reader

Supported

AUTISM CALENDAR DEADLINE

FEBRUARY 25 !

For March 2011

Submit listing here free!

RESEARCH

Researchers Reveal First Autism Candidate Gene That Demonstrates

Sensitivity to Sex Hormones

xrl.in/78ze

ScienceDaily — Washington

University researcher, Dr. Hu, Professor of Biochemistry and

Molecular Biology, and her team at the School of Medicine and Health

Sciences, have found that male and female sex hormones regulate

expression of an important gene in neuronal cell culture through a

mechanism that could explain not only higher levels of testosterone

observed in some individuals with autism, but also why males have a

higher incidence of autism than females.

The gene, RORA, encodes a protein that

works as a "master switch" for gene expression, and is critical in the

development of the cerebellum as well as in many other processes that

are impaired in autism. Dr. Hu's earlier research found that RORA was

decreased in the autistic brain. In this study, the research group

demonstrates that aromatase, a protein which is regulated by RORA, is

also reduced in autistic brains.

This is significant because aromatase

converts testosterone to estrogen. Thus, a decrease in aromatase is

expected to lead in part to build up of male hormones which, in turn,

further decrease RORA expression, as demonstrated in this study using a

neuronal cell model. On the other hand, female hormones were found to

increase RORA in the neuronal cells. The researchers believe that

females may be more protected against RORA deficiency not only because

of the positive effect of

For rest of today's SAR click here:www.sarnet.org/frm/forsar.htm

Today's SAR newslist

is human compiled and

provided through the support of

paid subscriptions.

- THANK YOU -

$35

for 1 year - or free!

www.sarnet.org

In

This Issue:

•

•

•

•

•

•

•

•

•

RESEARCH

Researchers Reveal First Autism Candidate Gene That Demonstrates

Sensitivity to Sex Hormones

U.Va. Receives Grant To Study Simulator's Effects on Teen Drivers with

Autism

TREATMENT

Puppets, Play Therapy Can Improve Social Skills, Speech For Children

With Autism

Dogs Bring Comfort, Focus For Autistic Children

NEWS

China's Autistic Children Need More State Support

RESOURCES

My Friend with Autism, Enhanced Edition Beverly Bishop

Book: Phil's Findings: Autism Can Severely Handicap A Family

MEDIA

What Causes Autism

PEOPLE

10 Years Later: Catching Up with the Mann Quadruplets

DO

SOMETHING ABOUT

AUTISM NOW

..

.. . Read, then

Forward

the Schafer Autism Report.

$35

for 1

year - or free!

www.sarnet.org

Hundreds

of Local

Autism Events

Web

/

Everywhere

Alabama

Alaska

Arizona

Arkansas

California

Colorado

Connecticut

Delaware

District

of Columbia

Florida

Georgia

Hawaii

Idaho

Web

/

Everywhere

Illinois

Indiana

Iowa

Kansas

Kentucky

Louisiana

Maine

land

Massachusetts

Michigan

Minnesota

Mississippi

Missouri

Web

/

Everywhere

Montana

Nebraska

Nevada

New

Hampshire

New

Jersey

New

Mexico

New

York

North

Carolina

North

Dakota

Ohio

Oklahoma

Oregon

Pennsylvania

Web

/

Everywhere

Rhode

Island

South

Carolina

South

Dakota

Tennessee

Texas

Utah

Vermont

Virginia

Washington

West

Virginia

Wisconsin

Wyoming

Web

/

Everywhere

Send

your LETTER

Now's the perfect time to order your free Puzzle

Piece kits and launch an autism awareness campaign in your community.

When we raise the funding necessary, ARI will see that important

research is done, including the large-scale, independent study of

vaccinated vs. unvaccinated children Click

here.

SAR Back

Issues

The

Autism Community

Supports the

Schafer Autism Report

..

.. . Read, then

Forward

the Schafer Autism Report.

$35

for 1

year - or free!

www.sarnet.org

Biomedical

Treatments for Autism Spectrum Disorders

Scientific References and Abstracts

www.autismbiomed.com

Copyright

Notice:

The above

items

are copyright protected. They are for our readers' personal education

or research purposes only and provided at their request. Articles may

not be further reprinted or used commercially without consent from the

copyright holders. To find the copyright holders, follow the referenced

website link provided at the beginning of each

item.

Lenny Schafer editor@...

The Schafer Autism Report is a non-profit corporation

Vol.

15 No. 10

Unsubscribe here: www.sarnet.org/frm/unsub2.htm

_______________________________________________

SARnets mailing list

SARnets@...

http://lists.igc.org/mailman/listinfo/sarnets

You can unsubscribe send email:

http://www.sarnet.org/frm/unsub2.htm

--

You are subscribed as:

deniseslist@...