Guest guest Posted February 14, 2007 Report Share Posted February 14, 2007 Do rashes & /or hives ever go with PSC (not due to meds) in anyone's experience here? Could the immune system suddenly get reactionary/rashy after getting PSC where it wasn't prior to that? --Meghan, mom to rashy Wyatt (PSC & UC 1/07: FAP 8/01: ?'s) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 14, 2007 Report Share Posted February 14, 2007 Hi Meghan; So sorry to hear about Wyatt's rashes/hives. Unfortunately, skin manifestations can often occur in inflammatory bowel disease ... see for example: Aliment Pharmacol Ther. 2004 Oct;20 Suppl 4:50-3. Review article: skin complications associated with inflammatory bowel disease. Tavarela Veloso F Department of Gastroenterology, Hospital de Sao Joao, Porto, Portugal. taveloso@... Cutaneous manifestations are well-recognized complications of Crohn's disease and ulcerative colitis. The incidence of these manifestations varies widely but, at the time of diagnosis, the mean incidence is around 10%. During the course of the disease, a great variety of skin lesions may develop, many of which are secondary to granulomatous cutaneous disease, reactive skin eruptions, nutritional deficiency and other associated conditions. The disorders that are directly related to the inflammatory process of Crohn's disease include perianal and peristomal ulcers and fistulae, metastatic Crohn's disease and oral granulomatous lesions. Histologically, the features are similar to those found in the inflamed bowel. These lesions usually respond to treatment of the underlying intestinal disease. The most common forms of reactive skin eruption are erythema nodosum and pyoderma gangrenosum. Certain subsets of patients are more susceptible to the development of erythema nodosum; in a previous report from our group, erythema nodosum was seen mainly in females, and in patients with colonic involvement and/or arthritis. This manifestation tends to occur during the first 2 years of the clinical course of the disease and may recur in approximately one-half of cases. Infliximab is highly effective in healing refractory lesions of erythema nodosum and pyoderma gangrenosum. Manifestations that are secondary to nutritional deficiency or associated conditions include acrodermatitis enteropathica, psoriasis and autoimmune disorders. For most of the cutaneous manifestations, the primary therapeutic target remains the bowel. Early aggressive therapy can minimize severe complications and maintenance treatment may prevent some devastating consequences. PMID: 15352894. One of the conditions mentioned in the above article is erythema nodosum ... this results in reddish, painful, tender lumps most commonly located in the front of the legs below the knees: http://www.medicinenet.com/erythema_nodosum/article.htm I don't know whether this is what Wyatt may be experiencing, but it would be worth talking this over with his doctor if you are concerned? Are the rash/hive areas very itchy for him? As you probably already know, itching/pruritus is very common in PSC. A prescription of rifampin was very helpful in controlling our son's pruritus. I hope this information helps. Best regards, Dave (father of (21); PSC 07/03; UC 08/03) > > Do rashes & /or hives ever go with PSC (not due to meds) in anyone's > experience here? Could the immune system suddenly get > reactionary/rashy after getting PSC where it wasn't prior to that? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2007 Report Share Posted February 15, 2007 This is interesting to me because when Bill was just 4 or 5 he awoke one night with what we thought were hives. He came into the bedroom and said "Mommy, I can't hold my blankie". His hands were so swollen he couldn't close them. So I stayed home with the baby [] while my husband went off the the ER with Bill since we realized it was all over his body and not just his hands. Anyway, the ER treated him with antihistamines also believing he had large hives. The next day was a Saturday and my pediatrician made the first and only house call we ever had after I called to tell him that Bill couldn't walk as he had large eruptions on the bottom of his feet as well. Anyway, the pediatrician said that they weren't hives because though they looked like it, they didn't itch ! I thought I remembered that he called it erythema nodosum. He couldn't say what caused it but since Bill had many allergies, we thought it might be allergy related.Was he already having liver problems? Did an infection cause the erythema nodosum and then effect the liver? Did he already have colitis? Who knows.It scares me to think that he has had something more serious going on all these years now that he is 24.Lee mother of Bill 24 PSC/UC 06/04 J pouch 06/05Hi Meghan;So sorry to hear about Wyatt's rashes/hives. Unfortunately, skin manifestations can often occur in inflammatory bowel disease ... see for example:Aliment Pharmacol Ther. 2004 Oct;20 Suppl 4:50-3. Review article: skin complications associated with inflammatory bowel disease.Tavarela Veloso FDepartment of Gastroenterology, Hospital de Sao Joao, Porto, Portugal. taveloso (AT) netc (DOT) pt. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 15, 2007 Report Share Posted February 15, 2007 I have been having bouts of erythema nodusm for about 6 months or so. I have found that nothing reall works and they go away on their own after making you feel that your legs are going to just fall off because it hurts so much. Hot compresses worked for minor relief. I hope this helps. > > > Hi Meghan; > > > > So sorry to hear about Wyatt's rashes/hives. Unfortunately, skin > > manifestations can often occur in inflammatory bowel disease ... see > > for example: > > > > Aliment Pharmacol Ther. 2004 Oct;20 Suppl 4:50-3. > > > > Review article: skin complications associated with inflammatory bowel > > disease. > > > > Tavarela Veloso F > > > > Department of Gastroenterology, Hospital de Sao Joao, Porto, > > Portugal. taveloso@... > > > >> . > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 16, 2007 Report Share Posted February 16, 2007 Having just finished reading a book about infectious diseases, I would take this to the ER to have it evaluated. Some rashes/hives are symptoms of infectious diseases, and if your son is on immunosuppressant drugs then he's more susceptible to IDs. That's my 2 cents. Don’t miss your chance to WIN 10 hours of private jet travel from Microsoft® Office Live Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2007 Report Share Posted February 21, 2007 Hi Meghan I suffered from hives about the time I think I got PSC [the pruritis started just beforehand]. I didnt go to the doctors for a long time after the urticaria died down as I thought the pruritis was part of the same thing. Perhaps there is a link - does anyone else have any history of urticaria/hives? I was told that the type of urticaria [traumatic] I had was due to my body attacking itself - perhaps it attacked my liver too? Kym Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 21, 2007 Report Share Posted February 21, 2007 I have had chronic hives since August 2006. I am seeing a skin specialist right now and her hypothesis is that my thyroid might be responsible as I have a low thyroid as well. I am a bit frustrated right now as there seems to be no answers. Just another instance of my body attacking itself… a PSC 03 From: [mailto: ] On Behalf Of curtiskym Sent: February 21, 2007 10:17 AM To: Subject: Re: rashes/hives Hi Meghan I suffered from hives about the time I think I got PSC [the pruritis started just beforehand]. I didnt go to the doctors for a long time after the urticaria died down as I thought the pruritis was part of the same thing. Perhaps there is a link - does anyone else have any history of urticaria/hives? I was told that the type of urticaria [traumatic] I had was due to my body attacking itself - perhaps it attacked my liver too? Kym Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.