Absence of Certain Proteins Causes Diabetes, and Rheumatoid Arthritis

[Guest guest]

Absence of Certain Proteins Causes Diabetes, and Rheumatoid Arthritis

The absence of related protein molecules, Puma and Bin, prompts immune cells

to turn against human organs they are meant to protect and cause type 1

diabetes and rheumatoid arthritis....

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Gray and colleagues from the Walter and Eliza Hall Institute's

Molecular Genetics of Cancer division and the University of Ballarat, have

discovered that this pair of protein molecules work together to kill

so-called 'self-reactive' immune cells that are programmed to attack the

body's own organs.

Autoimmune diseases, such as type-1 diabetes, rheumatoid arthritis,

inflammatory bowel disease and multiple sclerosis, develop when immune cells

launch an attack on the body's own cells, destroying important body organs

or structures.

Puma and Bim are so-called 'BH3-only' proteins that make cells die by a

process called apoptosis or self death. Defects in apoptosis proteins have

been linked to many human diseases, including cancer and neurodegenerative

disorders, according to an Eliza Hall statement.

Gray said one way the body protects itself against autoimmune disease is by

forcing most self-reactive immune cells to die during their development. " If

any self-reactive cells manage to reach maturity, the body normally has a

second safeguard of switching these potentially dangerous cells into an

inactive state, preventing them from causing autoimmune disease, " he said.

Gray is now collaborating with researchers who have identified human gene

defects linked to the development of autoimmune conditions.

" We now know that self-reactive cell death is an important protection

against autoimmunity, " Gray said. " The next stage of our work is to discover

whether defects in the cell death process cooperate with other factors to

cause human autoimmune disease. "

Immunity Sept. 2012

Related Articles

[Guest guest]

does this also cause attitsons disease. karen

Absence of Certain Proteins Causes Diabetes, and

Rheumatoid Arthritis

Absence of Certain Proteins Causes Diabetes, and Rheumatoid Arthritis

The absence of related protein molecules, Puma and Bin, prompts immune cells

to turn against human organs they are meant to protect and cause type 1

diabetes and rheumatoid arthritis....

Advertisement

Gray and colleagues from the Walter and Eliza Hall Institute's

Molecular Genetics of Cancer division and the University of Ballarat, have

discovered that this pair of protein molecules work together to kill

so-called 'self-reactive' immune cells that are programmed to attack the

body's own organs.

Autoimmune diseases, such as type-1 diabetes, rheumatoid arthritis,

inflammatory bowel disease and multiple sclerosis, develop when immune cells

launch an attack on the body's own cells, destroying important body organs

or structures.

Puma and Bim are so-called 'BH3-only' proteins that make cells die by a

process called apoptosis or self death. Defects in apoptosis proteins have

been linked to many human diseases, including cancer and neurodegenerative

disorders, according to an Eliza Hall statement.

Gray said one way the body protects itself against autoimmune disease is by

forcing most self-reactive immune cells to die during their development. " If

any self-reactive cells manage to reach maturity, the body normally has a

second safeguard of switching these potentially dangerous cells into an

inactive state, preventing them from causing autoimmune disease, " he said.

Gray is now collaborating with researchers who have identified human gene

defects linked to the development of autoimmune conditions.

" We now know that self-reactive cell death is an important protection

against autoimmunity, " Gray said. " The next stage of our work is to discover

whether defects in the cell death process cooperate with other factors to

cause human autoimmune disease. "

Immunity Sept. 2012

Related Articles

[Guest guest]

I don't know .

_____

From: blind-diabetics

[mailto:blind-diabetics ] On Behalf Of

Sent: Monday, September 17, 2012 5:09 AM

To: blind-diabetics

Subject: Re: Absence of Certain Proteins Causes Diabetes,

and Rheumatoid Arthritis

does this also cause attitsons disease. karen

Absence of Certain Proteins Causes Diabetes, and

Rheumatoid Arthritis

Absence of Certain Proteins Causes Diabetes, and Rheumatoid Arthritis

The absence of related protein molecules, Puma and Bin, prompts immune cells

to turn against human organs they are meant to protect and cause type 1

diabetes and rheumatoid arthritis....

Advertisement

Gray and colleagues from the Walter and Eliza Hall Institute's

Molecular Genetics of Cancer division and the University of Ballarat, have

discovered that this pair of protein molecules work together to kill

so-called 'self-reactive' immune cells that are programmed to attack the

body's own organs.

Autoimmune diseases, such as type-1 diabetes, rheumatoid arthritis,

inflammatory bowel disease and multiple sclerosis, develop when immune cells

launch an attack on the body's own cells, destroying important body organs

or structures.

Puma and Bim are so-called 'BH3-only' proteins that make cells die by a

process called apoptosis or self death. Defects in apoptosis proteins have

been linked to many human diseases, including cancer and neurodegenerative

disorders, according to an Eliza Hall statement.

Gray said one way the body protects itself against autoimmune disease is by

forcing most self-reactive immune cells to die during their development. " If

any self-reactive cells manage to reach maturity, the body normally has a

second safeguard of switching these potentially dangerous cells into an

inactive state, preventing them from causing autoimmune disease, " he said.

Gray is now collaborating with researchers who have identified human gene

defects linked to the development of autoimmune conditions.

" We now know that self-reactive cell death is an important protection

against autoimmunity, " Gray said. " The next stage of our work is to discover

whether defects in the cell death process cooperate with other factors to

cause human autoimmune disease. "

Immunity Sept. 2012

Related Articles