urso and nutrition

[Guest guest]

Does Urso cause certain nutrients not to be absorbed by the body? I

thought I read this somewhere.

Thanks

Clint

UC-1978 PSC-2006

[Guest guest]

That's news to me. A quick internet search does not show that connection.

However, those with Crohn's or UC are definitely prone malabsorption of

nutrients.

Arne

===========================================================

Does Urso cause certain nutrients not to be absorbed by the body? I thought I

read this somewhere.

Thanks

Clint

UC-1978 PSC-2006

[Guest guest]

-----Original Message----- From: " relaytech1960 "

Does Urso cause certain nutrients not to be

absorbed by the body?

PSC does this, all by it’s lonesome self.

J

Clin Gastroenterol. 1995 Apr;20(3):215-9.

Serum lipid and fat-soluble vitamin

levels in primary sclerosing cholangitis.

nsen

RA, Lindor KD,

Sartin

JS, LaRusso

NF, Wiesner

RH.

Mayo Clinic, Rochester, MN 55905, USA.

We reviewed the initial lipid and fat-soluble vitamin

levels in 56 patients with primary sclerosing cholangitis (PSC) enrolled in a randomized,

placebo-controlled trial evaluating ursodeoxycholic

acid. We also evaluated lipid and vitamin levels in a

group of 87 patients with advanced PSC being evaluated for liver

transplantation. Of the patients entering the therapeutic

trial, 41% had total serum cholesterol levels greater than the 95th percentile,

whereas only 20% had high-density lipoprotein cholesterol levels above normal,

and only one (2%) had an elevated triglyceride level. Total

cholesterol levels were correlated with serum bilirubin

levels and were lower in early versus later histologic

stages (206 +/- 61 vs. 248 +/- 79, p = 0.04). Of the

87 pretransplant patients, 29% had elevated serum

cholesterol levels and 17% had elevated serum triglyceride levels. Total serum cholesterol levels correlated inversely with

total serum bilirubin levels in this group. In patients in the therapeutic trial, vitamin A deficiency

was seen in 40%, vitamin D deficiency in 14%, and vitamin E deficiency in 2% of

those tested. More

prominent deficiencies of fat-soluble vitamins occurred in the pretransplant group of patients, with 82% deficient in

vitamin A, 57% deficient in vitamin D, and 43% deficient in vitamin E.

We conclude that hypercholesterolemia and fat-soluble

vitamin deficiencies are frequent in patients with PSC and

are more common with more severe disease. Patients

with PSC, especially with advanced liver disease, should be screened for

fat-soluble vitamin deficiencies and supplemented accordingly.

PMID: 7797830 [PubMed - indexed

for MEDLINE]

[Guest guest]

I found where I read about nutrition and urso. Check out the last

paragraph.

thanks

HUMAN BILE is made up of a combination of five different bile acids,

including ursodeoxycholic acid (UDCA). UDCA is " hydrophilic " (mixes

with water) while the other four bile acids are " hydrophobic " (don't

mix with water). These four hydrophoic bile acids are highly

corrosive and very thick. UDCA is the least corrosive, and because

it mixes with water, is thin and flows well.

The liver recycles bile from the digestive tract. Recycled bile

contains vitamins and minerals that are carried back to the liver to

enter the bloodstream. The liver produces " fresh " bile to replace

what was excreted as waste. Bilirubin is one of the waste products

that bile helps to eliminate. High bilirubin indicates bile is not

eliminating waste in the way it should. Essentially, the bile acid

production-to-reabsorption cycle is a " feedback loop " that tells the

liver how much bile to produce.

When PBC goes untreated, bile acids build up in the liver due to

inflammation and/or damage to the biliary tree. This inhibits the

normal secretion of bile into the digestive system. Consequently,

the liver does not reabsorb bile acids because the acids aren't

getting out to the digestive tract.. To compensate, the liver makes

more bile that can't get out, which increases the damage to the

liver. It's a vicious cycle.........

UDCA normally makes up about 5% of the mix of bile acids in the

liver. The remaining 95% is made up of the other four, more

corrosive bile acids. Taking ursodiol (synthetic UDCA) re-introduces

one missing bile acid into our digestive systems. Some of the

ursodiol is eliminated as waste, and some is reabsorbed. The

reabsorbed ursodiol fools the liver's feedback loop into producing

less of all five bile acids.

The aim is to take enough ursodiol to change the mix of bile acids so

that UDCA makes up about 50% of our bile.

This does two things:

1) Makes the mix of bile acids in the liver less corrosive, and

2) Thins the bile, improving the way it flows.

This results in slowing down the damage to the biliary tree. The

change in the mix of bile acids also affects our ability to absorb

vitamins and minerals. Fat-soluble vitamins are less likely to be

absorbed while water-soluble vitamins are more likely to be absorbed.

[Guest guest]

Makes sense to me, which is why some of us take ADEK vitamin supplements (fat

soluble vitamins). Again, keep in mind that ALL drugs have side affects. It's

always a balance of risks and benefits - clearly bile flow with some

malabsorption is preferable to no, or drastically reduced bile flow.

Arne

===========================================================

I found where I read about nutrition and urso. Check out the last paragraph.

....The change in the mix of bile acids also affects our ability to absorb

vitamins and minerals. Fat-soluble vitamins are less likely to be absorbed while

water-soluble vitamins are more likely to be absorbed.