Guest guest Posted July 24, 2005 Report Share Posted July 24, 2005 Sky: I'd be very careful about taking excess Metformin; it can cause lactic acidosis, which can be fatal in 50% of the cases. You might want to talk to your doc about chaning to the non-time release version of metformin or reducing the evening dose by 500 mgs and taking the regular metformin in the am. Alyne T2, Dx 8-03, D & E and Metformin __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 24, 2005 Report Share Posted July 24, 2005 Sky: I'd be very careful about taking excess Metformin; it can cause lactic acidosis, which can be fatal in 50% of the cases. You might want to talk to your doc about chaning to the non-time release version of metformin or reducing the evening dose by 500 mgs and taking the regular metformin in the am. Alyne T2, Dx 8-03, D & E and Metformin __________________________________________________ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 24, 2005 Report Share Posted July 24, 2005 Alyne A wrote: > Sky: > > I'd be very careful about taking excess Metformin; it > can cause lactic acidosis, which can be fatal in 50% > of the cases. You might want to talk to your doc about > chaning to the non-time release version of metformin > or reducing the evening dose by 500 mgs and taking the > regular metformin in the am. Taking above the recommended dose of metformin is really a waste of money, more than anything. Some drugs do not get more effective as you increase the dosage beyond a certain point. Metformin seems to be like that. Lactic acidosis is a potentially lethal side effect, however, it's quite rare, about 1 out 33,000 patients. It seems to be a risk of taking any dose of the drug rather than an excess of it. Also, it should not be taken by people with kidney problems and it should be discontinued temporarily when having general anesthesia or an x-ray which uses contrast media, as these things put high workloads on the kidneys. Edd Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 26, 2005 Report Share Posted July 26, 2005 Gretchen, she asked if I wanted to try metformin very shortly after it came out. I remember her telling me that I might see numbers in the 130s until it built up to its full effect. And to be patient. Perhaps that was before we had a good idea of how it worked. As it happens, I am still seeing her and will be on October 3. I am already making a list and will try to remember to put metformin build-up on it. Helen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 26, 2005 Report Share Posted July 26, 2005 > Gretchen, she asked if I wanted to try metformin very shortly after it > came out. Then she was unlikely to be thinking of Avandamet, as it's fairly recent. But when metformin first came out I doubt that anyone was talking about it having two different effects with different time frames, as at that time people were still arguing about whether it worked on gluconeogenesis or insulin resistance. > I am still seeing her and will be on October 3. I am already > making a list and will try to remember to put metformin build-up on it. Thanks. If time is short, don't waste it with this question, which is only theoretical. Discussing your DM has more practical implications and should come first. But if she says she has no more patients and wants to chat (unlikely), you could say you know someone who wants more information about this if she happens to know where one should look. Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 26, 2005 Report Share Posted July 26, 2005 > Gretchen, she asked if I wanted to try metformin very shortly after it > came out. Then she was unlikely to be thinking of Avandamet, as it's fairly recent. But when metformin first came out I doubt that anyone was talking about it having two different effects with different time frames, as at that time people were still arguing about whether it worked on gluconeogenesis or insulin resistance. > I am still seeing her and will be on October 3. I am already > making a list and will try to remember to put metformin build-up on it. Thanks. If time is short, don't waste it with this question, which is only theoretical. Discussing your DM has more practical implications and should come first. But if she says she has no more patients and wants to chat (unlikely), you could say you know someone who wants more information about this if she happens to know where one should look. Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 26, 2005 Report Share Posted July 26, 2005 > Gretchen, she asked if I wanted to try metformin very shortly after it > came out. Then she was unlikely to be thinking of Avandamet, as it's fairly recent. But when metformin first came out I doubt that anyone was talking about it having two different effects with different time frames, as at that time people were still arguing about whether it worked on gluconeogenesis or insulin resistance. > I am still seeing her and will be on October 3. I am already > making a list and will try to remember to put metformin build-up on it. Thanks. If time is short, don't waste it with this question, which is only theoretical. Discussing your DM has more practical implications and should come first. But if she says she has no more patients and wants to chat (unlikely), you could say you know someone who wants more information about this if she happens to know where one should look. Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 I did a quick google search using the words biphasic metformin response and got 753 hits. With just the words biphasic & metformin I got over 4000 hits. Theres gotta be what you need somewhere. Good luck. I hope it helps. Peace, Jim " I've been searching Google for some reference to the biphasic metformin response and can't find anything. " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 I did a quick google search using the words biphasic metformin response and got 753 hits. With just the words biphasic & metformin I got over 4000 hits. Theres gotta be what you need somewhere. Good luck. I hope it helps. Peace, Jim " I've been searching Google for some reference to the biphasic metformin response and can't find anything. " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 I did a quick google search using the words biphasic metformin response and got 753 hits. With just the words biphasic & metformin I got over 4000 hits. Theres gotta be what you need somewhere. Good luck. I hope it helps. Peace, Jim " I've been searching Google for some reference to the biphasic metformin response and can't find anything. " Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 > I did a quick google search using the words biphasic metformin > response and got 753 hits. With just the words biphasic & metformin I > got over 4000 hits. I did the same, and most of them were not what I was looking for. If you use quotes: " Biphasic metformin response " you get zero hits. If you don't use the quotes, you get articles discussing biphasic something else plus metformin. Many of them are about the TZDs. Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 > I did a quick google search using the words biphasic metformin > response and got 753 hits. With just the words biphasic & metformin I > got over 4000 hits. I did the same, and most of them were not what I was looking for. If you use quotes: " Biphasic metformin response " you get zero hits. If you don't use the quotes, you get articles discussing biphasic something else plus metformin. Many of them are about the TZDs. Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 Doing a search with www.scholar.google.com yielded 219 responses including the following article. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 3 1323-1332 Copyright © 2003 by The Endocrine Society Metformin Rapidly Increases Insulin Receptor Activation in Human Liver and Signals Preferentially through Insulin-Receptor Substrate-2 http://jcem.endojournals.org/cgi/content/full/88/3/1323 There may be more but I can't take the time just now. It's early Thurs morning and I have a deadline to meet. Bea Gretchen wrote >> I did a quick google search using the words biphasic metformin >> response and got 753 hits. With just the words biphasic & metformin I >> got over 4000 hits. > > I did the same, and most of them were not what I was looking for. If you > use > quotes: " Biphasic metformin response " you get zero hits. If you don't use > the quotes, you get articles discussing biphasic something else plus > metformin. Many of them are about the TZDs. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 Doing a search with www.scholar.google.com yielded 219 responses including the following article. The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 3 1323-1332 Copyright © 2003 by The Endocrine Society Metformin Rapidly Increases Insulin Receptor Activation in Human Liver and Signals Preferentially through Insulin-Receptor Substrate-2 http://jcem.endojournals.org/cgi/content/full/88/3/1323 There may be more but I can't take the time just now. It's early Thurs morning and I have a deadline to meet. Bea Gretchen wrote >> I did a quick google search using the words biphasic metformin >> response and got 753 hits. With just the words biphasic & metformin I >> got over 4000 hits. > > I did the same, and most of them were not what I was looking for. If you > use > quotes: " Biphasic metformin response " you get zero hits. If you don't use > the quotes, you get articles discussing biphasic something else plus > metformin. Many of them are about the TZDs. > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 > Doing a search with www.scholar.google.com yielded 219 responses > including the following article. > > The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 3 1323-1332 > Copyright © 2003 by The Endocrine Society > Metformin Rapidly Increases Insulin Receptor Activation in Human Liver and > Signals Preferentially through Insulin-Receptor Substrate-2 > http://jcem.endojournals.org/cgi/content/full/88/3/1323 Thanks. But I'm not sure what this has to do with the question at hand. > There may be more but I can't take the time just now. Same with me. I looked at about 50 papers, and none of them addressed the topic we were discussing. Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 27, 2005 Report Share Posted July 27, 2005 > Doing a search with www.scholar.google.com yielded 219 responses > including the following article. > > The Journal of Clinical Endocrinology & Metabolism Vol. 88, No. 3 1323-1332 > Copyright © 2003 by The Endocrine Society > Metformin Rapidly Increases Insulin Receptor Activation in Human Liver and > Signals Preferentially through Insulin-Receptor Substrate-2 > http://jcem.endojournals.org/cgi/content/full/88/3/1323 Thanks. But I'm not sure what this has to do with the question at hand. > There may be more but I can't take the time just now. Same with me. I looked at about 50 papers, and none of them addressed the topic we were discussing. Gretchen Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 Gretchen wrote: > I've been researching drug prices now that I'm officially elderly and > forced > to pay for my own drugs. (The joys of the Sunset Years.) ----------------------------------------------- Strange system you have there Gretchen - Here in Ontario, at age 65 we pay one annual fee of $100 and thereafter everything that is on the Ontario Health Insurance Plan is free - including glucometer strips!; however if your doc prescribes something NOT on the plan you do have to pay. I get my metformin free - BUT there is no extended release (XR) availability. CJ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 Gretchen wrote: > I've been researching drug prices now that I'm officially elderly and > forced > to pay for my own drugs. (The joys of the Sunset Years.) ----------------------------------------------- Strange system you have there Gretchen - Here in Ontario, at age 65 we pay one annual fee of $100 and thereafter everything that is on the Ontario Health Insurance Plan is free - including glucometer strips!; however if your doc prescribes something NOT on the plan you do have to pay. I get my metformin free - BUT there is no extended release (XR) availability. CJ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 Gretchen wrote: > I've been researching drug prices now that I'm officially elderly and > forced > to pay for my own drugs. (The joys of the Sunset Years.) ----------------------------------------------- Strange system you have there Gretchen - Here in Ontario, at age 65 we pay one annual fee of $100 and thereafter everything that is on the Ontario Health Insurance Plan is free - including glucometer strips!; however if your doc prescribes something NOT on the plan you do have to pay. I get my metformin free - BUT there is no extended release (XR) availability. CJ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 When doctors start wanting you to sign a DNR. CarolR Sue wrote: > At what age is one " officially elderly " ? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 When doctors start wanting you to sign a DNR. CarolR Sue wrote: > At what age is one " officially elderly " ? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 I know that was supposed to be joke, Carol, but the truth of the matter is, we should ALL have our DNRs in place well before need. An auto accident - or any kind of accident -- can happen to anyone, at any age. Vicki Re: Metformin > When doctors start wanting you to sign a DNR. > > CarolR > > Sue wrote: >> At what age is one " officially elderly " ? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 I know that was supposed to be joke, Carol, but the truth of the matter is, we should ALL have our DNRs in place well before need. An auto accident - or any kind of accident -- can happen to anyone, at any age. Vicki Re: Metformin > When doctors start wanting you to sign a DNR. > > CarolR > > Sue wrote: >> At what age is one " officially elderly " ? > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 i am 66, and i am going to be going grandma, my grandaughter calls me. with all the aches and diets, if i can get to the casino, i will take advantage of the senior citizen day. i have been getting discounts [they call it] since 55. i really don't know when we are condsidered elderly. Carol wrote:When doctors start wanting you to sign a DNR. CarolR Sue wrote: > At what age is one " officially elderly " ? Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 28, 2005 Report Share Posted September 28, 2005 i am 66, and i am going to be going grandma, my grandaughter calls me. with all the aches and diets, if i can get to the casino, i will take advantage of the senior citizen day. i have been getting discounts [they call it] since 55. i really don't know when we are condsidered elderly. Carol wrote:When doctors start wanting you to sign a DNR. CarolR Sue wrote: > At what age is one " officially elderly " ? Quote Link to comment Share on other sites More sharing options...
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