Guest guest Posted March 7, 2007 Report Share Posted March 7, 2007 I was diagnosed with PTSD, OCD, and Neurotic Depression back in 1996 a the VA in Palo Alto. They have the best psych team in the country for treating PTSD and other anxiety disorders. I have been on all the SSRIs. Zoloft is the worst SSRI as far as side effects that I have ever been on. One hour after I took a 25 mg tablet, I was driving my jeep and I felt like climbing out of my skin. Parasthesia (brain shock), abdominal muscle clenching, extreme mania. I felt wasted out of my mind. Incredible hallucinations, flashes of color. Like being trapped in an expressionist painting. I got home and ended up crawling on the carpet in my living room for two hours because I could not stand up or walk. At 1am I ended up in the emergency room at the VA Palo Alto. Imagine being caffeinated out of your mind, x 100. Imagine feeling like your arms and legs can never stop moving. That even though you are sitting still your moving 1000 miles per hour, you will end up crying and begging for it to pass thru your system. One NASTY DRUG (worse than Ergotimine,(foul, primitive med for migraines). I dont know why they have not taken it off the market. For those who have not had these side effects, your VERY LUCKY!. Andi, PSC/Crohns 2001- 2002 See this link for further information on Zoloft- http://en.wikipedia.org/wiki/Sertraline quote from article- "In 2004, Pfizer, the company that makes the brand Zoloft, was sued for allegedly covering up side effects" Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 7, 2007 Report Share Posted March 7, 2007 - and yet it has been a lifesaver for millions of others (one of which lives in the same house as me). As always, it is quite likely that people will react to meds differently. Some are much more sensitive than others. Cindy had an extreme reaction to a simple iron supplement, my wife is extremely sensitive to nearly all narcotics, Cheryl cannot tolerate Urso, Penny had a terrible reaction to Gentamyacin. From www.fda.gov (for zoloft): Liver Disease–As might be predicted from its primary site of metabolism, liver impairment can affect the elimination of sertraline. In patients with chronic mild liver impairment (N=10, 8 patients with Child-Pugh scores of 5-6 and 2 patients with Child-Pugh scores of 7-8) who received 50 mg sertraline per day maintained for 21 days, sertraline clearance was reduced, resulting in approximately 3-fold greater exposure compared to age-matched volunteers with no hepatic impairment (N=10). We have to be careful with anything we ingest that is processed by the liver. From the above scenario, it sounds like you could effectively have three times the intended dosage due to reduced efficiency of elimination (with an impaired liver). Arne ....One NASTY DRUG (worse than Ergotimine,(foul, primitive med for migraines). I dont know why they have not taken it off the market. For those who have not had these side effects, your VERY LUCKY!. Andi, PSC/Crohns 2001-2002 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 7, 2007 Report Share Posted March 7, 2007 I have to agree with Arne. Zoloft did work for me, myself, who does not suffer from liver disease-or any orther for that matter. I took it to treat a bout of mild depression and it worked wonders for me. I have had several friends that have taken it with great succes as well. We all need to read and make decisions regarding medications that we put in our bodies. It is all about making informed and intellegent choices regarding our health, and those that we care for. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 9, 2007 Report Share Posted March 9, 2007 From www.fda.gov (for zoloft): Liver Disease–As might be predicted from its primary site of metabolism, liver impairment can affect the elimination of sertraline. In patients with chronic mild liver impairment (N=10, 8 patients with Child-Pugh scores of 5-6 and 2 patients with Child-Pugh scores of 7-8) who received 50 mg sertraline per day maintained for 21 days, sertraline clearance was reduced, resulting in approximately 3-fold greater exposure compared to age-matched volunteers with no hepatic impairment (N=10). We have to be careful with anything we ingest that is processed by the liver. From the above scenario, it sounds like you could effectively have three times the intended dosage due to reduced efficiency of elimination (with an impaired liver). *** Exactly... If you have cirrhosis... SSRIS can be unpleasant...and the withdrawl can be hell..I think they now mention it on the label of most SSRIs. Iam sure I will have to get back on that stuff if Iam to be listed. Hate them. Andi Quote Link to comment Share on other sites More sharing options...
Recommended Posts
Join the conversation
You are posting as a guest. If you have an account, sign in now to post with your account.
Note: Your post will require moderator approval before it will be visible.