Gastroperesis in Patients with Inactive Crohn's Disease

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http://www.biomedcentral.com/1471-230X/7/11/abstract Case report .Gastroparesis in Patients with Inactive Crohns Disease: a case series Jon O sson , Wim P.M. Hopman , Wim J.G. Oyen and Joost P.H. Drenth BMC Gastroenterology 2007, 7:11 doi:10.1186/1471-230X-7-11 Published 21 March 2007Abstract (provisional) The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production. Background Few studies have described patients with foregut dysmotility in inflammatory bowel disease. The aim of this case series was to evaluate clinical characteristics of 5 patients with inflammatory bowel disease and symptoms and signs of upper gut dysmotility. Case presentations. We have observed four patients with Crohns disease and one with indeterminate colitis who all had severe symptoms and signs of gastroparesis. We reviewed medical records of all cases. Gastric emptying of a solid meal was assessed by scintigraphy. Small bowel enteroclysis, gastroduodenoscopy and colonoscopy with biopsies were performed to estimate the activity of the disease and to exclude organic obstruction. None of the patients had any signs of active inflammation or stricture. All of the patients had markedly delayed gastric emptying with a mean t 1/2 of 234 minutes (range 110-380 minutes; normal values

54-94 minutes). Conclusion Clinicians should consider impaired gastric emptying when evaluating patients with Crohns disease and severe symptoms of upper gut dysmotility, which cannot be attributed to active inflammation or organic obstruction of the digestive tract. Symptoms in these patients are refractory to various therapeutic interventions including tube feeding and gastric surgery. Ami mom to - 9 yrs - Double Lung Tx 2/26/2006, PSC - Pre-Liver Tx, Central DI, Steroid Induced Diabetes,

Hypothyroid, GERD, High BP, ADD, Anemia, Osteopenia, Gastroperesis, Varices mom to Emma - 13 yrs - Migraines stepmom to - 14 yrs - ADHD, ODD ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

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