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Re: Hives and PSC

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I don't know the answer Clint, but I am now into month 9 of having severe chronic hives. It seems to me that others have had this problem, but I haven't found any reading to indicate that the hives direcly related to the liver. I have found studies that link hives to the thyroid, which I have had issues with. Thankfull, I haven't developed UC or Chrons yet (despite a very prevalent family history), but as I am going insane with iching some nights I am wondering if the hives aren't just another autoimmune problem.

So I haven't added anything to your discussion, but I am venting because despite the fact that I have been itching from PSC for nearly 5 years, the hives are so much worse.

a

PSC 2003

Hives and PSC

I have a question for the group. Before I was diagnoised with PSC, I had severe hives. It lasted about 2 years. I used Allegra to keep it half way under control. They never did find the cause as is the case with most hive cases. I was wondering if there is any connection to the liver?ClintUC-1979 Psc-2006

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Hi Clint - I have suffered from hives sporadically throughout my life,

the worst of which was around 5-6years ago and lasted around a year. A

doctor [Ellis] here at the Radcliffe hospital in Oxford [uK] is

now doing some tests on by bloods as my Immuno-globulin is very low and

this is an area which he is currently researching in conjunction with

PSC. I will post here as soon as I hear anything which may be relevant

to the group - although this may take a while.

Regards Kym [psc 06]

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---a,

Hives (idopathic urticaria) are definitely autoimmune related. They had

to run there course with me. They finally went away. Then about 3

months after they left, I got diagnoised with PSC. One night after my

hives hasd left, I thought my hives were conming back. I would wake up

in the middle of the night and itch like crazy. The only difference was

there were no weals. I latter found out that the later itching was from

my liver. I still suspect hives have some connection to liver disease.

By the way, when I initially got the hives, they checked my lfts and

they all came back normal. That was 2 years before I got diagnoised

with PSC

Clint

UC 1979 PSC 2006

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Hi Clint,

Interesting story. I have never had hives prior to this episode. I have had PSC for 4+ years now and have been itching all that time. I find the itching to be two different sensations. Interestingly, when I was finally diagnosed with chronic urticaria a skin specialist prescribed UVB light therapy that MizKit raves about. I am right beside her in saying that most of my itching from the liver has disappeared. My hands and feet used to be awful and now there is no itching there - only over the rest of my body where the hives are.

Recently my doctor sent me for C1 Esterase (sp?) test. I had the results faxed to me and this came back a little high. I see my specialist next week so I am hoping that he will interpret what this means to me. I am sure there will still be no easy fix....

Take care,

a

Re: Hives and PSC

---a,Hives (idopathic urticaria) are definitely autoimmune related. They had to run there course with me. They finally went away. Then about 3 months after they left, I got diagnoised with PSC. One night after my hives hasd left, I thought my hives were conming back. I would wake up in the middle of the night and itch like crazy. The only difference was there were no weals. I latter found out that the later itching was from my liver. I still suspect hives have some connection to liver disease. By the way, when I initially got the hives, they checked my lfts and they all came back normal. That was 2 years before I got diagnoised with PSCClintUC 1979 PSC 2006

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Kym,

I am really interested in the link between PSC and low immunoglobulins. I

have had cvid (common variable immune deficiency) ever since birth (42 years

ago), and am treated with ivig (replacement therapy) every 21 days. I was

diagnosed with PSC about 10 years ago, and nobody has ever thought there was

a link.

Anything you find with regards to the link (or Dr Ellis finds) would be

really interesting to both myself and my medical team which is increasing in

size every year!

Thanks,

Penny (Australia)

> doctor [Ellis] here at the Radcliffe hospital in Oxford [uK] is

> now doing some tests on by bloods as my Immuno-globulin is very low and

> this is an area which he is currently researching in conjunction with

> PSC. I will post here as soon as I hear anything which may be relevant

> to the group - although this may take a while.

> Regards Kym [psc 06]

>

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