Neurologic manifestations of UC

[Guest guest]

Neurologic

manifestations of ulcerative colitis

Authors:

Scheid, R.; Teich, N.

Source: European Journal of Neurology,

Volume 14, Number 5, May 2007 Publisher: Blackwell Publishing

Abstract:

Ulcerative

colitis (UC) has traditionally been considered to be an inflammatory disease

limited to the colonic mucosa. However, since it has

been shown that UC is frequently accompanied by various extraintestinal

disorders, there is increasing evidence that UC may also manifest in the

nervous system. The following review focuses

particularly on these possible manifestations of UC, both in the peripheral

(PNS), and in the central nervous system (CNS). A

systematic literature search according to the MEDLINE database was performed

for this purpose. Although a reliable differentiation

may clinically not always be possible, three major pathogenic entities can be

differentiated: (i) cerebrovascular

disease as a consequence of thrombosis and thromboembolism;

(ii) systemic and cerebral vasculitis; (iii) probably

immune mediated neuropathy and cerebral demyelination. With the exception of thromboembolism

and sensorineural hearing loss, evidence for a causal

relationship relies merely on single case reports or retrospective case series. Considering the CNS-manifestations, similarities between

UC-associated disorders of the white matter and acute disseminated

encephalomyelitis (ADEM) are obvious. Epileptic

seizures, unspecified encephalopathies and confusional states are most likely epiphenomena that have

to be regarded symptomatic rather than as own entities. A

prospective study on the neurologic aspects of UC

would be very welcome.

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Son Ken (32) UC 91 - PSC 99 Listed 7/21 @ Baylor Dallas