Chronic Renal Dysfunction a Major Concern After Liver Transplant: Presented at EASL

[Guest guest]

Chronic

Renal Dysfunction a Major Concern After Liver

Transplant: Presented at EASL

By Jill Stein

BARCELONA, SPAIN -- April 13, 2007 -- Chronic renal dysfunction is an important

complication after liver transplantation, and more than a fourth of patients

satisfy criteria for chronic kidney disease (CKD) at 5 years, according to

research presented here at the 42nd Annual Meeting of the European

Association for the Study of the Liver (EASL).

, MD, professor, division of hepatology,

ish Liver Transplant Unit, Royal Infirmary of Edinburgh, Scotland, and

associates, reviewed the records of 135 patients who received 148 elective

liver transplants at their institution during a recent 4-year period.

" Few studies have focused on the prevalence of chronic kidney disease

after liver transplantation, " Dr. said on April 13th. " What's more, little information is available on the

rate of decline in renal function, which is important in the prediction of

future chronic kidney disease and the need for dialysis. "

Overall, 106 patients were alive 5 years post-transplant.

The prevalence of CKD increased progressively during the first 6 months

post-transplant and thereafter showed no change.

At 5 years post-transplant, 28% of patients had CKD, 3% had severe CKD, and 1%

had renal failure.

The cumulative rate of renal failure necessitating haemodialysis

was 1.5% by 5 years.

Mean glomerular filtration rate (GFR) at 5 years was

31 mL/min/1.73m2, which was less than the preoperative value (P < .01).

Nearly half (46%) of patients showed deterioration of renal function that was

faster than the rate expected with age, with a mean rate of decline of 4.5

mL/min/1.73 m2 per year.

By 5 years post-transplant, these patients had a lower GFR (P = .03), higher serum creatinine

(P = .03), and a trend towards a

greater prevalence of CKD compared with those who did not demonstrate such a

decline (P = .07).

Dr. said that additional studies are needed to identify modifiable risk

factors for both the development of CKD and decline in renal function.

[Presentation title: Chronic Renal Failure

Post Liver Transplant: Prevalence and Rate of Decline. Abstract

164]

Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (32) UC 91 - PSC 99 Listed 7/21 @ Baylor Dallas

[Guest guest]

Barb, Renal failure can happen after transplant because of the rejection drugs. They told my husband that he needed to drink at least 36 ounces of water a day or he will end up on dialysis in 10 to 15 years. He takes prograf, it is one of the hardest on the kidney's I think. So for the ones that is on prograf drink alot of water to help prevent this. Tina

Chronic Renal Dysfunction a Major Concern After Liver Transplant: Presented at EASL

Chronic Renal Dysfunction a Major Concern After Liver Transplant: Presented at EASL

By Jill SteinBARCELONA, SPAIN -- April 13, 2007 -- Chronic renal dysfunction is an important complication after liver transplantation, and more than a fourth of patients satisfy criteria for chronic kidney disease (CKD) at 5 years, according to research presented here at the 42nd Annual Meeting of the European Association for the Study of the Liver (EASL). , MD, professor, division of hepatology, ish Liver Transplant Unit, Royal Infirmary of Edinburgh, Scotland, and associates, reviewed the records of 135 patients who received 148 elective liver transplants at their institution during a recent 4-year period."Few studies have focused on the prevalence of chronic kidney disease after liver transplantation," Dr. said on April 13th. "What's more, little

information is available on the rate of decline in renal function, which is important in the prediction of future chronic kidney disease and the need for dialysis."Overall, 106 patients were alive 5 years post-transplant.The prevalence of CKD increased progressively during the first 6 months post-transplant and thereafter showed no change.At 5 years post-transplant, 28% of patients had CKD, 3% had severe CKD, and 1% had renal failure.The cumulative rate of renal failure necessitating haemodialysis was 1.5% by 5 years.Mean glomerular filtration rate (GFR) at 5 years was 31 mL/min/1.73m2, which was less than the preoperative value (P < .01).Nearly half (46%) of patients showed deterioration of renal function that was faster than the rate expected with age, with a mean rate of decline of 4.5 mL/min/1.73 m2

per year.By 5 years post-transplant, these patients had a lower GFR (P = .03), higher serum creatinine (P = .03), and a trend towards a greater prevalence of CKD compared with those who did not demonstrate such a decline (P = .07).Dr. said that additional studies are needed to identify modifiable risk factors for both the development of CKD and decline in renal function.[Presentation title: Chronic Renal Failure Post Liver Transplant: Prevalence and Rate of Decline. Abstract 164]

Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (32) UC 91 - PSC 99 Listed 7/21 @ Baylor Dallas

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