Coffee Consumption & Risk of Liver Cancer: A Meta-Analysis

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Gastroenterology

Volume

132, Issue 5, May 2007, Pages 1740-1745

Coffee

Consumption and Risk of Liver Cancer: A Meta-Analysis

na

C. Larsson, and Alicja Wolk

Division of Nutritional Epidemiology, The National

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden

Background & Aims: Mounting

evidence indicates that coffee drinking may protect against liver injury and

lower the risk of liver cancer. We quantitatively

assessed the relation between coffee consumption and the risk of liver cancer

in a meta-analysis of epidemiologic studies. Methods: Relevant studies were

identified by searching MEDLINE (from 1966 to February 2007) and the reference

lists of retrieved articles. We included cohort and case–control

studies that reported relative risk (RR) estimates with 95% confidence

intervals (CIs) of primary liver cancer or hepatocellular carcinoma by quantitative categories of

coffee consumption. Study-specific RRs

were pooled using a random-effects model. Results: Four cohort and 5

case–control studies, involving 2260 cases and 239,146 noncases, met the inclusion criteria. All

studies observed an inverse relation between coffee consumption and risk of

liver cancer, and in 6 studies the association was statistically significant. Overall, an increase in consumption of 2 cups of coffee

per day was associated with a 43% reduced risk of liver cancer (RR, 0.57; 95%

CI, 0.49–0.67). There was no statistically

significant heterogeneity among studies (P

= .17). In stratified analysis, the summary RRs of liver cancer for an increase in consumption of 2

cups of coffee per day were 0.69 (95% CI, 0.55–0.87) for persons without

a history of liver disease and 0.56 (95% CI, 0.35–0.91) for those with a

history of liver disease. Conclusions: Findings from this

meta-analysis suggest that an increased consumption of coffee may reduce the

risk of liver cancer.

Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (33) UC 91 - PSC 99 Listed 7/21 @ Baylor Dallas

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coffee and decrease risk of "hepatocellular carcinoma"

Do we think that might apply to cholangiocarcinoma as well? I only drink one cup a day, but maybe I'll up to two!

Jeff

PSC 1989

See what's free at AOL.com.

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-----Original

Message-----

Do we think

that might apply to cholangiocarcinoma as well?

These doctors certainly

do -

http://jnci.oxfordjournals.org/cgi/reprint/jnci%3b97/4/293.pdf

(2005- 8 page PDF)

and, these doctor’s do -

http://lib.bioinfo.pl/auth:Habu,D (2006

study - 6th study down)

A 2003 study (http://sciencelinks.jp/j-east/article/200311/000020031103A0187310.php

) which says:

By the large scale epidemiological study carried out in Harvard University, it has

lower symptomatic gallstone crisis risk of drinking group, when the group which

drank the coffee including the caffeine every day over several cups was

compared with not drinking group. In this paper, the

outline of that study was introduced. And, the action

mechanism was examined in comparison with coffee and green tea. First the mechanism of the cholesterol gallstone formation

was explained. Next, the following were described :

That an intake of the coffee promotes the secretion of the cholecystokinin and

that causes the gallbladder contraction and exacerbates movement of intestine. The caffeine in the coffee suppresses the crystallization

of the cholesterol, and increases the bile flow rate. And,

it promotes the energy consumption and decreases the body fat.

As the result, it was explained that an intake of the coffee might

suppress the gallstone generation. Though the catechin

of the component of the green tea was called having antioxidative effect and

cancer inhibition action and blood cholesterol increase inhibitory effect,

etc., it explained that there was no large scale epidemiology research on

gallstone and green tea.

From Univ of Florida/ Shands -

Habitual Coffee Drinking Reduces

Risk of Liver Cancer in Japanese http://www.ufscc.ufl.edu/Patient/cancernews.aspx?section=cancernews & id=33312

There’s probably much more, but I have to take Ken to the Dermatologist today, so better get busy. HTH

Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (33) UC 91 - PSC 99 Listed 7/21 @ Baylor Dallas