Re: chronic pancreatitis

[Guest guest]

Thank you for once again helping me out !! You are a kind soul.

I would be very interested in any info you may have. Nothing about

braden seems to be typical - including his pancreas ! He has had his

IgG 4 tested as well as other IgG subclass testing and he has NO

detectable IgG 4 and quite low total IgG including low IgG1,2 and 4

subclass deficiencies. His immunologist said that it is not a well

known or well understood problem associated with immune deficiencies

to have autoimmune problems too. That is why he is ordering some (very

expensive !!) T cell testing

Thanks again !!

Lori

lucky mom blessed with wonderfully wild 10 year old triplets

>

> Dear Lori;

>

> Has Braden been tested for elevated IgG4? This seems to be diagnostic

> of autoimmune pancreatitis, which is often very difficult to

> distinguish from PSC. I can point you to references on this if you

> are interested in more information. Apparently autoimmune

> pancreatitis responds well to corticosteroids.

>

> The other possible link between PSC and pancreatitis is the cystic

> fibrosis gene, CFTR. Mutations in this gene can cause susceptibility

> to pancreatitis, and have been linked to PSC in some studies. Other

> genes that can influence chronic pancreatitis are the pancreatic

> secretory trypsin inhibitor gene (SPINK1) and the cationic

> trypsinogen gene (PRSS1). Testing for the levels of trypsinogen might

> therefore be worth pursuing. From what I have read, enteric-coated

> pancreatic enzymes are the drugs of choice for treating steatorrhea,

> while conventional non-enteric coated enzymes are preferred for

> managing pain in chronic pancreatitis. Again, I can point you to

> references on this if you are interested.

>

> Best regards,

>

> Dave

> (father of (22); PSC 07/03; UC 08/03)

>