Dee's email to neuropathic pain/slides

[Guest guest]

I was reading the slides on neuropathic pain, I guess the reason that the ativan works for me, is not just because it calms the pfm from this slide the benz are pretty much like anticonvulsants-

Slide 5. But right now on the front line, mostly what we use are anticonvulsants, anticonvulsants in disguise, antiarrhythmics, and antiarrhythmics in disguise.The anticonvulsants in disguise are benzodiazepines. Many say, "Well, how can that rule be true when you're using drugs like clonazepam for neuropathic pain?" Well, what's the first drug that you use to treat a witness seizure? It's Valium, Ativan, etc. These are anticonvulsants. Clonazepam's first US Food and Drug Administration (FDA) indication was for seizures -- for partial seizures.Create a Home Theater Like the Pros. Watch the video on AOL Home.

[Guest guest]

So glad you caught that Carolyn....

I too would agree that something like the Atavan/Valium can work wonders and to 'me' far more safe than the anticonvulsants or antiseizures (as long as it's not abused) but again just 'my' thoughts on it.

Dee ~

Dee's email to neuropathic pain/slides

I was reading the slides on neuropathic pain, I guess the reason that the ativan works for me, is not just because it calms the pfm from this slide the benz are pretty much like anticonvulsants-

Slide 5.

But right now on the front line, mostly what we use are anticonvulsants, anticonvulsants in disguise, antiarrhythmics, and antiarrhythmics in disguise.The anticonvulsants in disguise are benzodiazepines. Many say, "Well, how can that rule be true when you're using drugs like clonazepam for neuropathic pain?" Well, what's the first drug that you use to treat a witness seizure? It's Valium, Ativan, etc. These are anticonvulsants. Clonazepam's first US Food and Drug Administration (FDA) indication was for seizures -- for partial seizures.

[Guest guest]

I just wish I knew why Ativan/Valium works better than narcotics

for nerve pain. I still think of these drugs as medications for people who are

anxious, nervous, mildly psychotic, etc. It is not a drug that I would be

comfortable telling people that I took all the time. But this afternoon, I was

desperate for some relief. I had taken my regular every eight hours drugs, and

one breakthrough pill, but no relief. I knew I could lie very still with an ice

pack and that would help, but I didn’t want to do that. I had a couple of

minor things I wanted to do, but the pain was too severe to do anything. So I

took an Ativan, and within a few minutes felt enough relief that I could move

around. Just wondering why this works as it does for pain.

nne

From:

VulvarDisorders [mailto:VulvarDisorders ] On

Behalf Of Dee Troll

Sent: Saturday, March 29, 2008 4:28 PM

To: VulvarDisorders

Subject: Re: Dee's email to neuropathic pain/slides

So glad you caught that Carolyn....

I too would agree that something like the Atavan/Valium can

work wonders and to 'me' far more safe than the anticonvulsants or antiseizures

(as long as it's not abused) but again just 'my' thoughts on it.

Dee ~

-----

Original Message -----

From: Carolyn52192@...

To: VulvarDisorders

Sent: Saturday, March 29,

2008 10:50 AM

Subject: Dee's email to

neuropathic pain/slides

I was reading the slides on neuropathic pain, I guess the reason

that the ativan works for me, is not just because it calms the pfm from this

slide the benz are pretty much like anticonvulsants-

Slide 5.

But right now on the front line, mostly what we use are anticonvulsants,

anticonvulsants in disguise, antiarrhythmics, and antiarrhythmics in disguise.

The anticonvulsants in

disguise are benzodiazepines. Many say, " Well, how can that rule be true

when you're using drugs like clonazepam for neuropathic pain? " Well,

what's the first drug that you use to treat a witness seizure? It's Valium,

Ativan, etc. These are anticonvulsants. Clonazepam's first US Food and

Drug Administration (FDA) indication was for seizures -- for partial seizures.

[Guest guest]

HI nne, so glad to hear the Ativan helped so fast for you.

Maybe this will help explain how the benzodiazepine, Ativan, works.

(on the gaba receptors like Gabapentin)

Dee

=================================

Scientists Identify Mechanism for Chronic Pain Relief

Posted by admin in January 27th 2008

Pain Therapy Tags: Benzodiazepines, Brain Receptors, Nerve Cells, Pain Therapy, Spinal Cord Pain

Some of the specific receptors located in our skin, joints, and other internal organs are responsible for sensing the painful stimuli in our bodies. Receptive signals are relayed by these specialized nerve fibers relay which are generated at the periphery of the brain. Here the pain turns in to conscious stage. Hanns Ulrich Zeilhofer, Professor at the ‘Institute of Pharmaceutical Sciences’ at ETH Zurich, and at the ‘Institute of Pharmacology and Toxicology’ of the ‘University of Zurich’

The spinal cord is placed at such a position that works as a pain filter. It assures that the pain is not felt just by feeble stimuli like touching. The ‘inhibitory nerve cells’ that are located in the spinal dorsal horn perform this function. The spinal dorsal horn releases the’ molecule-amino butyric acid (GABA)’at the points of contacts between the specialized nerve cells. It is also called the “synapses”.GABA subsequently causes activation in the chloride channels over these cells and these nerve cells then start relaying the ‘pain signals’ to the brain.

This inhibiting action of GABA gets substantially suppressed in case of the presence of a chronic inflammatory disease like the ‘rheumatoid arthritis’ or the stage of nerve damage by any type of injury. In such a situation the brain starts receiving unfiltered pain signals.

Benzodiazepine like valium, the sedative drug, stimulates the activity of GABA and helps in reducing the acute pain. It acts when the drug is supplemented directly in to the spinal cord with an injection in to the spinal canal. However such treatment is very much specific.

Benzodiazepines are generally prescribed and administered systemically in tablet form. It makes an impact in the spinal cord and also in the brain and could cause some adverse effects for the patients. The drugs cause sedation, impair memory, and can even lead to addiction. It has also been observed that the prolonged use of this drug develops immunity with time. Scientists therefore generally advise to avoid this medication in chronic pain conditions.

Although the importance of GABA as a potential function has long been known in the pain control but the study made by Ulritch Zeilhofer has researched out that there are four different sub-types of GABA on which the benzodiazepines act. These receptors though known, but were almost neglected till recently as a potential targets for pain treatments.

Ulritch Zeilhofer’s research team could identify two distinct sub-types of GABAA receptors that play a role of mediator in the spinal pain control. Results of various experiments conducted revealed that “the pharmacological enhancement of spinal GABA receptor function inhibits the relay of pain signals to the brain”.

Researchers feel that designing a drug that specifically address the two sub-types of GABAA receptors will be a big leap in the pain therapy. If this happens in near future then it will be possible to treat chronic pain with minimum or no side effects. “The challenge is now for pharmaceutical companies to develop drugs that specifically target these receptors in humans”, says Ulritch Zeilhofer.

SOURCE:

http://www.healthpm.com/scientists-identify-mechanism-for-chronic-pain-relief.html

[Guest guest]

HI nne, so glad to hear the Ativan helped so fast for you.

Maybe this will help explain how the benzodiazepine, Ativan, works.

(on the gaba receptors like Gabapentin)

Dee

=================================

Scientists Identify Mechanism for Chronic Pain Relief

Posted by admin in January 27th 2008

Pain Therapy Tags: Benzodiazepines, Brain Receptors, Nerve Cells, Pain Therapy, Spinal Cord Pain

Some of the specific receptors located in our skin, joints, and other internal organs are responsible for sensing the painful stimuli in our bodies. Receptive signals are relayed by these specialized nerve fibers relay which are generated at the periphery of the brain. Here the pain turns in to conscious stage. Hanns Ulrich Zeilhofer, Professor at the ‘Institute of Pharmaceutical Sciences’ at ETH Zurich, and at the ‘Institute of Pharmacology and Toxicology’ of the ‘University of Zurich’

The spinal cord is placed at such a position that works as a pain filter. It assures that the pain is not felt just by feeble stimuli like touching. The ‘inhibitory nerve cells’ that are located in the spinal dorsal horn perform this function. The spinal dorsal horn releases the’ molecule-amino butyric acid (GABA)’at the points of contacts between the specialized nerve cells. It is also called the “synapses”.GABA subsequently causes activation in the chloride channels over these cells and these nerve cells then start relaying the ‘pain signals’ to the brain.

This inhibiting action of GABA gets substantially suppressed in case of the presence of a chronic inflammatory disease like the ‘rheumatoid arthritis’ or the stage of nerve damage by any type of injury. In such a situation the brain starts receiving unfiltered pain signals.

Benzodiazepine like valium, the sedative drug, stimulates the activity of GABA and helps in reducing the acute pain. It acts when the drug is supplemented directly in to the spinal cord with an injection in to the spinal canal. However such treatment is very much specific.

Benzodiazepines are generally prescribed and administered systemically in tablet form. It makes an impact in the spinal cord and also in the brain and could cause some adverse effects for the patients. The drugs cause sedation, impair memory, and can even lead to addiction. It has also been observed that the prolonged use of this drug develops immunity with time. Scientists therefore generally advise to avoid this medication in chronic pain conditions.

Although the importance of GABA as a potential function has long been known in the pain control but the study made by Ulritch Zeilhofer has researched out that there are four different sub-types of GABA on which the benzodiazepines act. These receptors though known, but were almost neglected till recently as a potential targets for pain treatments.

Ulritch Zeilhofer’s research team could identify two distinct sub-types of GABAA receptors that play a role of mediator in the spinal pain control. Results of various experiments conducted revealed that “the pharmacological enhancement of spinal GABA receptor function inhibits the relay of pain signals to the brain”.

Researchers feel that designing a drug that specifically address the two sub-types of GABAA receptors will be a big leap in the pain therapy. If this happens in near future then it will be possible to treat chronic pain with minimum or no side effects. “The challenge is now for pharmaceutical companies to develop drugs that specifically target these receptors in humans”, says Ulritch Zeilhofer.

SOURCE:

http://www.healthpm.com/scientists-identify-mechanism-for-chronic-pain-relief.html

[Guest guest]

Ativan enhances the effects of some other drugs so if you took pain medication

and it didn't help and then take ativan it can cause the pain medication to work

better. But your doctor should approve it.

Ora

On Sat, 29 Mar 2008 19:00:10 -0400, " millburytimes "

wrote:

>I just wish I knew why Ativan/Valium works better than narcotics for nerve

>pain. I still think of these drugs as medications for people who are

>anxious, nervous, mildly psychotic, etc. It is not a drug that I would be

>comfortable telling people that I took all the time. But this afternoon, I

>was desperate for some relief. I had taken my regular every eight hours

>drugs, and one breakthrough pill, but no relief. I knew I could lie very

>still with an ice pack and that would help, but I didn't want to do that. I

>had a couple of minor things I wanted to do, but the pain was too severe to

>do anything. So I took an Ativan, and within a few minutes felt enough

>relief that I could move around. Just wondering why this works as it does

>for pain.

>

>nne

[Guest guest]

You're more than welcome hon.

I was given Ativan when I had Bells Palsy.. I still wonder why, *smile*... but the doctor said just to relax me more than anything... and I really wasn't hyper about it (more PO'd with looking like Quasi Moto with the whole half of the face just totally sagging as it causes loss of all the nerves that control the muscles)... it was wonderful for helping me sleep and to have a sort of 'Oh well attitude' *grin*..but for me I only needed 1/4th to 1/2 of the tablet.

I think I slept 14 hrs the first time on a full pill. (but I go 'out' easy on most things) I still have about 3/4ths of them left and that was probably 8 years ago *grin* so I sure didn't get addicted, LOL but I like keeping them around as a 'just in case' thing. (and yes they're still good and can keep up to 20 some years if kept out of humidity and in the dark.. I can't say I had pain with it so no idea if it helps that but apparently it does and it makes sense too as to why.

Good luck hon,

Dee ~

Re: Dee's email to neuropathic pain/slides

Dee, you are awesome! Thank you. Maybe this is another thing I shouldtry. Love,>> HI nne, so glad to hear the Ativan helped so fast for you. > Maybe this will help explain how the benzodiazepine, Ativan, works. > (on the gaba receptors like Gabapentin)> > Dee> =================================> > Scientists Identify Mechanism for Chronic Pain Relief> Posted by admin in January 27th 2008 > Pain Therapy Tags: Benzodiazepines, Brain Receptors, NerveCells, Pain Therapy, Spinal Cord Pain

> Some of the specific receptors located in our skin, joints, andother internal organs are responsible for sensing the painful stimuliin our bodies. Receptive signals are relayed by these specializednerve fibers relay which are generated at the periphery of the brain.Here the pain turns in to conscious stage. Hanns Ulrich Zeilhofer,Professor at the `Institute of Pharmaceutical Sciences' at ETH Zurich,and at the `Institute of Pharmacology and Toxicology' of the`University of Zurich'> The spinal cord is placed at such a position that works as a painfilter. It assures that the pain is not felt just by feeble stimulilike touching. The `inhibitory nerve cells' that are located in thespinal dorsal horn perform this function. The spinal dorsal hornreleases the' molecule-amino butyric acid (GABA)'at the points ofcontacts between the specialized nerve cells. It is also called the"synapses".GABA subsequently causes activation in the chloridechannels over these cells and these nerve cells then start relayingthe `pain signals' to the brain.

> This inhibiting action of GABA gets substantially suppressed in caseof the presence of a chronic inflammatory disease like the `rheumatoidarthritis' or the stage of nerve damage by any type of injury. In sucha situation the brain starts receiving unfiltered pain signals.> Benzodiazepine like valium, the sedative drug, stimulates theactivity of GABA and helps in reducing the acute pain. It acts whenthe drug is supplemented directly in to the spinal cord with aninjection in to the spinal canal. However such treatment is very muchspecific.> Benzodiazepines are generally prescribed and administeredsystemically in tablet form. It makes an impact in the spinal cord andalso in the brain and could cause some adverse effects for thepatients. The drugs cause sedation, impair memory, and can even leadto addiction. It has also been observed that the prolonged use of thisdrug develops immunity with time. Scientists therefore generallyadvise to avoid this medication in chronic pain conditions.> Although the importance of GABA as a potential function has longbeen known in the pain control but the study made by Ulritch Zeilhoferhas researched out that there are four different sub-types of GABA onwhich the benzodiazepines act. These receptors though known, but werealmost neglected till recently as a potential targets for pain treatments.> Ulritch Zeilhofer's research team could identify two distinctsub-types of GABAA receptors that play a role of mediator in thespinal pain control. Results of various experiments conducted revealedthat "the pharmacological enhancement of spinal GABA receptor functioninhibits the relay of pain signals to the brain".> > Researchers feel that designing a drug that specifically address thetwo sub-types of GABAA receptors will be a big leap in the paintherapy. If this happens in near future then it will be possible totreat chronic pain with minimum or no side effects. "The challenge isnow for pharmaceutical companies to develop drugs that specificallytarget these receptors in humans", says Ulritch Zeilhofer.> SOURCE: > >http://www.healthpm.com/scientists-identify-mechanism-for-chronic-pain-relief.html>

[Guest guest]

You're more than welcome hon.

I was given Ativan when I had Bells Palsy.. I still wonder why, *smile*... but the doctor said just to relax me more than anything... and I really wasn't hyper about it (more PO'd with looking like Quasi Moto with the whole half of the face just totally sagging as it causes loss of all the nerves that control the muscles)... it was wonderful for helping me sleep and to have a sort of 'Oh well attitude' *grin*..but for me I only needed 1/4th to 1/2 of the tablet.

I think I slept 14 hrs the first time on a full pill. (but I go 'out' easy on most things) I still have about 3/4ths of them left and that was probably 8 years ago *grin* so I sure didn't get addicted, LOL but I like keeping them around as a 'just in case' thing. (and yes they're still good and can keep up to 20 some years if kept out of humidity and in the dark.. I can't say I had pain with it so no idea if it helps that but apparently it does and it makes sense too as to why.

Good luck hon,

Dee ~

Re: Dee's email to neuropathic pain/slides

Dee, you are awesome! Thank you. Maybe this is another thing I shouldtry. Love,>> HI nne, so glad to hear the Ativan helped so fast for you. > Maybe this will help explain how the benzodiazepine, Ativan, works. > (on the gaba receptors like Gabapentin)> > Dee> =================================> > Scientists Identify Mechanism for Chronic Pain Relief> Posted by admin in January 27th 2008 > Pain Therapy Tags: Benzodiazepines, Brain Receptors, NerveCells, Pain Therapy, Spinal Cord Pain

> Some of the specific receptors located in our skin, joints, andother internal organs are responsible for sensing the painful stimuliin our bodies. Receptive signals are relayed by these specializednerve fibers relay which are generated at the periphery of the brain.Here the pain turns in to conscious stage. Hanns Ulrich Zeilhofer,Professor at the `Institute of Pharmaceutical Sciences' at ETH Zurich,and at the `Institute of Pharmacology and Toxicology' of the`University of Zurich'> The spinal cord is placed at such a position that works as a painfilter. It assures that the pain is not felt just by feeble stimulilike touching. The `inhibitory nerve cells' that are located in thespinal dorsal horn perform this function. The spinal dorsal hornreleases the' molecule-amino butyric acid (GABA)'at the points ofcontacts between the specialized nerve cells. It is also called the"synapses".GABA subsequently causes activation in the chloridechannels over these cells and these nerve cells then start relayingthe `pain signals' to the brain.

> This inhibiting action of GABA gets substantially suppressed in caseof the presence of a chronic inflammatory disease like the `rheumatoidarthritis' or the stage of nerve damage by any type of injury. In sucha situation the brain starts receiving unfiltered pain signals.> Benzodiazepine like valium, the sedative drug, stimulates theactivity of GABA and helps in reducing the acute pain. It acts whenthe drug is supplemented directly in to the spinal cord with aninjection in to the spinal canal. However such treatment is very muchspecific.> Benzodiazepines are generally prescribed and administeredsystemically in tablet form. It makes an impact in the spinal cord andalso in the brain and could cause some adverse effects for thepatients. The drugs cause sedation, impair memory, and can even leadto addiction. It has also been observed that the prolonged use of thisdrug develops immunity with time. Scientists therefore generallyadvise to avoid this medication in chronic pain conditions.> Although the importance of GABA as a potential function has longbeen known in the pain control but the study made by Ulritch Zeilhoferhas researched out that there are four different sub-types of GABA onwhich the benzodiazepines act. These receptors though known, but werealmost neglected till recently as a potential targets for pain treatments.> Ulritch Zeilhofer's research team could identify two distinctsub-types of GABAA receptors that play a role of mediator in thespinal pain control. Results of various experiments conducted revealedthat "the pharmacological enhancement of spinal GABA receptor functioninhibits the relay of pain signals to the brain".> > Researchers feel that designing a drug that specifically address thetwo sub-types of GABAA receptors will be a big leap in the paintherapy. If this happens in near future then it will be possible totreat chronic pain with minimum or no side effects. "The challenge isnow for pharmaceutical companies to develop drugs that specificallytarget these receptors in humans", says Ulritch Zeilhofer.> SOURCE: > >http://www.healthpm.com/scientists-identify-mechanism-for-chronic-pain-relief.html>