Baclofen - Amitriptyline -

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, if you will go to our homepage at: http://health.groups.yahoo.com/group/VulvarDisorders/ You can do a search on Baclofen. Some of our members have used this combination cream from Dr. Haefner. Some of them may not be active on the group right now, but keep posting and asking questions and hopefully someone will be able to help. To do a search, the "SEARCH" box is almost directly under our Vulvar Disorders Welcome Sign (again on the home page). Hope this helps.... ~Chelle I mentioned that I'm on a compounded topical treatment. It's Amitriptyline & Baclofen. Baclofen is a muscle relaxant. I'm getting a lot of relief from this. The burning has subsided a great deal and the pelvic floor muscles (which were in a constant spasm/guarding/clenching mode) are more calmed down. My doctor, a leading Vulvodynia Specialist, Dr. Hope Haefner out of the Univ of Mich said she's been getting good results with this. Here's the recipe: Amitriptyline 2%Baclofen 2%WWB 2% - Water Washable Base oh, then it saysAmitriptyline 2% / Baclofen in WWB 30 ML Apply 1/2 CC 1-3 times daily as directed The 1st week I applied every morning and everynight. I just apply every night before bedtime now. Apply it to the vestibule, vulva, perineum (that'swhat I do). I don't put inside (ask Mike thepharmacist... he's really nice). Healthway Compounding Pharmacy2544 McLeon Dr. N. Suite 2Saginaw, MI 48604 www.healthwayrx.com Wishing everyone painfree days! Kathy Amitriptyline 2%/baclofen 2% in water (washable base (Elavil 2%/Lioresal 2% in water washable base) Elavil (AstraZeneca Pharmaceuticals LP, Wilmington, DE) Lioresal (Geigy Novartis Pharmaceuticals Corp., East Hanover, NJ) Topical amitriptyline 2% with baclofen 2% in water washable base (WWB); squirt 0.5 mL from syringe onto finger and apply to affected area one to three times daily. Dispense 30-day supply Common reactions (amitriptyline) Irritation, contact dermatitis, dry mouth,

drowsiness, dizziness, constipation, weight gain, urinary retention, tachycardia, blurred vision, confusion Serious reactions (amitriptyline) Seizures, stroke, myocardial infarction, agranulocytosis, thrombocytopenia Common reactions (baclofen) Drowsiness, dizziness, weakness, nausea, confusion, hypotension, headache, insomnia, constipation, muscle weakness, rash, sweating, fatigue Serious reactions (baclofen) Depression, respiratory problems, ataxia, syncope, seizures, hallucinations, exacerbation of spasticity prn, as needed; MI, myocardial infarction. Generally, the side effects of topical medications are less than when taken systemically. Choosing the proper vehicle for these

medications is as important as choosing the proper medications or combinations. In general, creams contain more preservatives and stabilizers and often produce burning on application, whereas ointments are usually better tolerated. Some clinicians prefer commercially available topical medications, whereas others prefer to compound the medications. It is important to have a close relationship with a compounding pharmacist who can help to determine the proper combination of ingredients. Specific instructions should be included, emphasizing the area for the medication to be applied (vulva, vestibule, vagina, etc.).