Guest guest Posted January 28, 2001 Report Share Posted January 28, 2001 Azathioprine Azathioprine (Imuran) Azathioprine (ay-zah-THIGH-oh-preen) Pregnancy Category: D Gen-Azathioprine Imuran (Rx) Classification: Immunosuppressant Action/Kinetics: Antimetabolite that is quickly split to form mercaptopurine. To be effective, the drug must be given during the induction period of the antibody response. The precise mechanism in depressing the immune response is unknown, but it suppresses cell-mediated hypersensitivities and alters antibody production. Inhibits synthesis of DNA, RNA, and proteins and may interfere with meiosis and cellular metabolism. The mechanism for its effect on autoimmune diseases is not known. Is readily absorbed from the GI tract. The anuric client manifests increased effectiveness and toxicity (up to twofold). Onset: 6-8 weeks for rheumatoid arthritis. t1/2: 3 hr. Uses: As an adjunct to prevent rejection in renal homotransplantation. In adult clients meeting criteria for classic or definite rheumatoid arthritis as defined by the American Rheumatism Association. Restrict use to clients with severe, active, and erosive disease that is not responsive to conventional therapy. Investigational: Chronic ulcerative colitis, generalized myasthenia gravis, to control the progression of Behçet's syndrome (especially eye disease), Crohn's disease (low doses). Contraindications: Treatment of rheumatoid arthritis in pregnancy or in clients previously treated with alkylating agents. Pregnancy and lactation. Special Concerns: Hematologic toxicity is dose-related and may occur late in the course of therapy; may be more severe in renal transplant clients undergoing rejection. Although used in children, safety and efficacy have not been established. Side Effects: Hematologic: Leukopenia, thrombocytopenia, macrocytic anemia, severe bone marrow depression selective erythrocyte aplasia. GI: N & V, diarrhea, abdominal pain, steatorrhea. CNS: Fever, malaise. Other: Increased risk of carcinoma severe infections (fungal, viral, bacterial, and protozoal), and hepatotoxicity are major side effects. Also, skin rashes, alopecia, myalgias, increase in liver enzymes, hypotension, negative nitrogen balance. Overdose Management: Symptoms: Large doses may result in bone marrow hypoplasia bleeding, infection, and death. Treatment: Approximately 45% can be removed from the body following 8 hr of hemodialysis. Drug Interactions: ACE inhibitors / Risk of severe leukopenia Allopurinol / Pharmacologic effect of azathioprine R/T liver breakdown Anticoagulants / Anticoagulant effect Corticosteroids / With azathioprine, may cause muscle wasting after prolonged therapy Cyclosporine / Plasma cyclosporine levels Echinacea / Do not give with azathioprine Methotrexate / Plasma levels of the active metabolite, 6-mercaptopurine Tubocurarine / Tubocurarine effect and other nondepolarizing neuromuscular blocking agents How Supplied: Powder For Injection: 100 mg; Tablet: 50 mg Dosage •Tablets, IV Use in renal homotransplantation. Adults and children, initial: 3-5 mg/kg (120 mg/m2), 1-3 days before or on the day of transplantation; maintenance: 1-3 mg/kg (45 mg/m2) daily. Rheumatoid arthritis, SLE. Adults and children, tablets, initial: 1 mg/kg (50-100 mg); then, increase dose by 0.5 mg/kg/day after 6-8 weeks and thereafter q 4 weeks, up to maximum of 2.5 mg/kg/day; maintenance: lowest effective dose. Dosage should be reduced in clients with renal dysfunction. Myasthenia gravis. 2-3 mg/kg/day. However, side effects occur in more than 35% of clients. To control progression of Behçet's syndrome. 2.5 mg/kg/day. To treat Crohn's disease. 75-100 mg/day. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2001 Report Share Posted January 29, 2001 In a message dated 1/29/01 4:59:54 PM Pacific Standard Time, eipoly@... writes: << I am reading this right I think it says that there is a drug contradition of Imuran with metho? eileen >> Eileen, that is how I read it too. I know there are a few in the group that take both. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2001 Report Share Posted January 29, 2001 I am reading this right I think it says that there is a drug contradition of Imuran with metho? eileen >From: Lu1953@... >Reply-To: Rpolychondritis >To: Rpolychondritis >Subject: Imuran >Date: Sun, 28 Jan 2001 20:49:15 EST > >Azathioprine >Azathioprine (Imuran) >Azathioprine >(ay-zah-THIGH-oh-preen) >Pregnancy Category: D Gen-Azathioprine Imuran (Rx) >Classification: Immunosuppressant >Action/Kinetics: Antimetabolite that is quickly split to form >mercaptopurine. >To be effective, the drug must be given during the induction period of the >antibody response. The precise mechanism in depressing the immune response >is >unknown, but it suppresses cell-mediated hypersensitivities and alters >antibody production. Inhibits synthesis of DNA, RNA, and proteins and may >interfere with meiosis and cellular metabolism. The mechanism for its >effect >on autoimmune diseases is not known. Is readily absorbed from the GI tract. >The anuric client manifests increased effectiveness and toxicity (up to >twofold). Onset: 6-8 weeks for rheumatoid arthritis. t1/2: 3 hr. >Uses: As an adjunct to prevent rejection in renal homotransplantation. In >adult clients meeting criteria for classic or definite rheumatoid arthritis >as defined by the American Rheumatism Association. Restrict use to clients >with severe, active, and erosive disease that is not responsive to >conventional therapy. Investigational: Chronic ulcerative colitis, >generalized myasthenia gravis, to control the progression of Behçet's >syndrome (especially eye disease), Crohn's disease (low doses). >Contraindications: Treatment of rheumatoid arthritis in pregnancy or in >clients previously treated with alkylating agents. Pregnancy and lactation. >Special Concerns: Hematologic toxicity is dose-related and may occur late >in >the course of therapy; may be more severe in renal transplant clients >undergoing rejection. Although used in children, safety and efficacy have >not >been established. >Side Effects: Hematologic: Leukopenia, thrombocytopenia, macrocytic anemia, >severe bone marrow depression selective erythrocyte aplasia. GI: N&V, >diarrhea, abdominal pain, steatorrhea. CNS: Fever, malaise. Other: >Increased >risk of carcinoma severe infections (fungal, viral, bacterial, and >protozoal), and hepatotoxicity are major side effects. Also, skin rashes, >alopecia, myalgias, increase in liver enzymes, hypotension, negative >nitrogen >balance. >Overdose Management: Symptoms: Large doses may result in bone marrow >hypoplasia bleeding, infection, and death. Treatment: Approximately 45% can >be removed from the body following 8 hr of hemodialysis. >Drug Interactions: ACE inhibitors / Risk of severe leukopenia Allopurinol >/ >Pharmacologic effect of azathioprine R/T liver breakdown Anticoagulants / >Anticoagulant effect Corticosteroids / With azathioprine, may cause muscle >wasting after prolonged therapy Cyclosporine / Plasma cyclosporine levels >Echinacea / Do not give with azathioprine Methotrexate / Plasma levels of >the active metabolite, 6-mercaptopurine Tubocurarine / Tubocurarine effect >and other nondepolarizing neuromuscular blocking agents >How Supplied: Powder For Injection: 100 mg; Tablet: 50 mg >Dosage >•Tablets, IV Use in renal homotransplantation. >Adults and children, initial: 3-5 mg/kg (120 mg/m2), 1-3 days before or on >the day of transplantation; maintenance: 1-3 mg/kg (45 mg/m2) daily. >Rheumatoid arthritis, SLE. >Adults and children, tablets, initial: 1 mg/kg (50-100 mg); then, increase >dose by 0.5 mg/kg/day after 6-8 weeks and thereafter q 4 weeks, up to >maximum >of 2.5 mg/kg/day; maintenance: lowest effective dose. Dosage should be >reduced in clients with renal dysfunction. >Myasthenia gravis. >2-3 mg/kg/day. However, side effects occur in more than 35% of clients. >To control progression of Behçet's syndrome. >2.5 mg/kg/day. >To treat Crohn's disease. >75-100 mg/day. > > > _________________________________________________________________________ Get Your Private, Free E-mail from MSN Hotmail at http://www.hotmail.com. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted January 29, 2001 Report Share Posted January 29, 2001 Eileen - I read it that Echinacea should not be given with azathiprine (Imuran) or methotrexate. Echinacea is supposed to boost the immune system, whereas metho and Imuran are supposed to depress it, so it would defeat the object. (I do hope you are not right as I am taking both!!!!) Love, Liz --- Eileen Pidgeon eipoly@...> wrote: > I am reading this right I think it says that there > is a drug contradition of > Imuran with metho? > eileen > > > >From: Lu1953@... > >Reply-To: Rpolychondritis > >To: Rpolychondritis > >Subject: Imuran > >Date: Sun, 28 Jan 2001 20:49:15 EST > > > >Azathioprine > >Azathioprine (Imuran) > >Azathioprine > >(ay-zah-THIGH-oh-preen) > >Pregnancy Category: D Gen-Azathioprine Imuran (Rx) > >Classification: Immunosuppressant > >Action/Kinetics: Antimetabolite that is quickly > split to form > >mercaptopurine. > >To be effective, the drug must be given during the > induction period of the > >antibody response. The precise mechanism in > depressing the immune response > >is > >unknown, but it suppresses cell-mediated > hypersensitivities and alters > >antibody production. Inhibits synthesis of DNA, > RNA, and proteins and may > >interfere with meiosis and cellular metabolism. The > mechanism for its > >effect > >on autoimmune diseases is not known. Is readily > absorbed from the GI tract. > >The anuric client manifests increased effectiveness > and toxicity (up to > >twofold). Onset: 6-8 weeks for rheumatoid > arthritis. t1/2: 3 hr. > >Uses: As an adjunct to prevent rejection in renal > homotransplantation. In > >adult clients meeting criteria for classic or > definite rheumatoid arthritis > >as defined by the American Rheumatism Association. > Restrict use to clients > >with severe, active, and erosive disease that is > not responsive to > >conventional therapy. Investigational: Chronic > ulcerative colitis, > >generalized myasthenia gravis, to control the > progression of Behçet's > >syndrome (especially eye disease), Crohn's disease > (low doses). > >Contraindications: Treatment of rheumatoid > arthritis in pregnancy or in > >clients previously treated with alkylating agents. > Pregnancy and lactation. > >Special Concerns: Hematologic toxicity is > dose-related and may occur late > >in > >the course of therapy; may be more severe in renal > transplant clients > >undergoing rejection. Although used in children, > safety and efficacy have > >not > >been established. > >Side Effects: Hematologic: Leukopenia, > thrombocytopenia, macrocytic anemia, > >severe bone marrow depression selective erythrocyte > aplasia. GI: N&V, > >diarrhea, abdominal pain, steatorrhea. CNS: Fever, > malaise. Other: > >Increased > >risk of carcinoma severe infections (fungal, viral, > bacterial, and > >protozoal), and hepatotoxicity are major side > effects. Also, skin rashes, > >alopecia, myalgias, increase in liver enzymes, > hypotension, negative > >nitrogen > >balance. > >Overdose Management: Symptoms: Large doses may > result in bone marrow > >hypoplasia bleeding, infection, and death. > Treatment: Approximately 45% can > >be removed from the body following 8 hr of > hemodialysis. > >Drug Interactions: ACE inhibitors / Risk of severe > leukopenia Allopurinol > >/ > >Pharmacologic effect of azathioprine R/T liver > breakdown Anticoagulants / > >Anticoagulant effect Corticosteroids / With > azathioprine, may cause muscle > >wasting after prolonged therapy Cyclosporine / > Plasma cyclosporine levels > >Echinacea / Do not give with azathioprine > Methotrexate / Plasma levels of > >the active metabolite, 6-mercaptopurine > Tubocurarine / Tubocurarine effect > >and other nondepolarizing neuromuscular blocking > agents > >How Supplied: Powder For Injection: 100 mg; Tablet: > 50 mg > >Dosage > >•Tablets, IV Use in renal homotransplantation. > >Adults and children, initial: 3-5 mg/kg (120 > mg/m2), 1-3 days before or on > >the day of transplantation; maintenance: 1-3 mg/kg > (45 mg/m2) daily. > >Rheumatoid arthritis, SLE. > >Adults and children, tablets, initial: 1 mg/kg > (50-100 mg); then, increase > >dose by 0.5 mg/kg/day after 6-8 weeks and > thereafter q 4 weeks, up to > >maximum > >of 2.5 mg/kg/day; maintenance: lowest effective > dose. Dosage should be > >reduced in clients with renal dysfunction. > >Myasthenia gravis. > >2-3 mg/kg/day. However, side effects occur in more > than 35% of clients. > >To control progression of Behçet's syndrome. > >2.5 mg/kg/day. > >To treat Crohn's disease. > >75-100 mg/day. > > > > > > > > _________________________________________________________________________ > Get Your Private, Free E-mail from MSN Hotmail at > http://www.hotmail.com. > > > Quote Link to comment Share on other sites More sharing options...
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