finding the cure for neuropathic pain

June 9, 2012

Scientists May Have Found Key to Neuropathic Pain

Diabetes Health Staff

May 26, 2012

A compound found in excessive quantities in the glucose of people with

diabetes <http://www.diabeteshealth.com/> may hold the key to successful

treatment of neuropathic pain, says an international team of researchers.

The compound, methylglyoxal, attacks and modifies a protein, called Nav1.8,

in nerve endings.

This damage causes nerves to become much more sensitive to pain and

temperature extremes. The result in people with diabetes is neuropathy

opathy/> , nerve damage, and pain, especially in the limbs. An estimated 50

percent of people with diabetes suffer from this demoralizing and

debilitating condition.

Researchers, led by the University of Warwick in the UK, think that removing

methylglyoxal from diabetic <http://www.diabeteshealth.com/> glucose could

be one way to counteract the development of neuropathy. They are currently

looking into an enzyme called Glo1, which causes methylglyoxal to undergo a

chemical change that cancels its ability to attack nerve endings.

Damage from high blood

been a known factor for many years. But pinpointing this one specific effect

opens the door for an effective anti-pain therapy.

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Categories: Anti

High

r/> Blood Sugar, Limbs

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