Re: What does is take to convince the Cochrane Hepatobiliary Group?

April 25, 2007

i gained about 20 lbs or more on urso. i hardly eat but never lose weight.See what's free at AOL.com.

April 25, 2007

> I still think they are spending too much time trying to prove

URSO's worth and are doing it to the detriment of other, newer

drugs. I understand where their coming from, it lowers LFT's so it

*has* to be doing something good, but without proof, they need to

move on and try something new.

I agree Barb; how about URSO + fish oils for starters .... this just

published:

HEPATOLOGY 45: 864-869 (2007)

Omega-3 fatty acids alleviate chemically induced acute hepatitis by

suppression of cytokines

Christoph Schmöcker, Karsten H. Weylandt, Lena Kahlke, Jingdong Wang,

Hartmut Lobeck, Gisa Tiegs, Berg, Jing X. Kang

Abstract

Cytokines such as tumor necrosis factor alpha (TNF-a) are key factors

in liver inflammation. Supplementation with essential omega-3

polyunsaturated fatty acids (n-3 PUFA) has been demonstrated to lower

TNF-a and IL-1 production in mononuclear cells. An inflammation-

dampening effect has been observed with increased omega-3 fatty acid

supplementation in several inflammatory diseases. In this study, we

used the transgenic fat-1 mouse, expressing a Caenorhabditis elegans

desaturase endogenously forming n-3 PUFA from n-6 PUFA, to analyze

the effect of an increased n-3 PUFA tissue status in the macrophage-

dependent acute D-galactosamine/lipopolysaccaride (D-GalN/LPS)

hepatitis model. We show less severe inflammatory liver injury in fat-

1 mice with a balanced n-6/n-3 PUFA ratio as evidenced by reduced

serum alanine aminotransferase levels and less severe histological

liver damage. This decreased inflammatory response was associated

with decreased plasma TNF-a levels and with reduced hepatic gene

expression of TNF-a, IL-1, IFN-g and IL-6 in fat-1 mice, leading to a

decreased rate of apoptosis in livers from fat-1 animals, as measured

by DAPI-staining. Conclusion: The results of this study offer

evidence for an inflammation dampening effect of omega-3

polyunsaturated fatty acids in the context of liver inflammation.

Dave R.

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