new molecule. . .

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w%3D%3D> Biological Clock Molecule Could Become New Type 2 Treatment

UC San Diego scientists have discovered a molecule involved in regulating

the biological clock that could open a new path for treating type 2

diabetes. The molecule, dubbed KL001, controls a key protein, cryptochrome,

that regulates the biological clock (circadian rhythm) in plants, animals,

and humans. In doing so, cryptochrome indirectly affects the liver's

production of glucose. KL001 can be manipulated to induce cryptochrome to

slow the liver's glucose production, thus creating a possible new

therapeutic approach to type 2 diabetes.

The circadian rhythm controls the timing of certain metabolic processes. For

example, nightly hormonal signals tell the body to go into a fasting state

because it's getting ready to sleep. By day, when people are active and

eating, fasting signals are suppressed so that the body will produce more

glucose for energy. In the case of people with diabetes, whose glucose

levels go too high, the ability to " tell " the liver to ease off glucose

production could help them achieve better control.

The path to finding KL001 started two years ago when a research team led by

Steve Kay, dean of the Division of Biological Sciences at UC San Diego,

discovered a biochemical link between diabetes and the circadian rhythm. The

team determined that cryptochrome, already known to regulate the biological

clocks of plants and animals, also regulates the liver's glucose production.

That insight led to speculation about ways that cryptochrome could be

controlled and the eventual discovery of the KL001 molecule. Read

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