question for Andy, dosing at 2 h intervals??

[Guest guest]

Andy

If someone doses ALA and DMSA every 2 h during the daytime and every 4

h at night, would they have to change the dose at night?

Like suppose they are taking 25 mg doses of each q 2 h during the day,

what doses would they take q 4 h at night? Or is this not recommended?

Thanks

[Guest guest]

I've been doing a similar schedule with 2:40 intervals during

the day, and 4 hours at night. I'm on 25 mg DMSA, and

won't add ALA for a while. I'm in my 8th DMSA round, and

transitioning toward a higher DMSA dosage. It's working fine

for me with minimal problems (I feel better when chelating).

The 4 hour interval was too long for my body and I got some

redistribution systems about about 3.5 hours. So I wanted to go

to a more frequent schedule that was " clock syncronized " , and

would also be OK when I add ALA. I keep my dosage the same during

the night. I use the timer referenced in the links section.

I had the same question when I started on this schedule, and I

reasoned that it's the slower metabolism during sleep that allows

stretching the interval to 4 hours, so the dosage should remain

the same. I'll be interested if others have had experiences that

are similar or contrary.

-= Alan

>

>

>

> Andy

>

> If someone doses ALA and DMSA every 2 h during the daytime and every 4

> h at night, would they have to change the dose at night?

>

> Like suppose they are taking 25 mg doses of each q 2 h during the day,

> what doses would they take q 4 h at night? Or is this not

recommended?

>

> Thanks

>

>

>

[Guest guest]

TK--- This is much more the one hour past dosage timing for both

chelators at the timing change - this will cause a

large fluctuation in blood concentration and redistribution.

General guidelines call to stop the round if one is more than one

hour late with a dose. To try and change the dosage back and forth to

compensate between 2 & 4hr will be very hard if it can be done at all.

I would [strongly] not recommend doing this and

would recommend people sticking to the general protocol for safety

so they do not screw something up and hurt themselves as it is very

easy to do so with just the standard protocol and I hate to see

people suffer when they get it wrong.

The end choice is the individuals but this is not what we recommend

doing unless Andy wants to come up with dosage

equations for this purpose and ok's it.

>

>

>

> Andy

>

> If someone doses ALA and DMSA every 2 h during the daytime and every 4

> h at night, would they have to change the dose at night?

>

> Like suppose they are taking 25 mg doses of each q 2 h during the day,

> what doses would they take q 4 h at night? Or is this not

recommended?

>

> Thanks

>

>

>

[Guest guest]

TK--- just to clarify so people do not get confused - this is not a

similar schedule at all. the one below calls for a 2hr difference in

dosage timing----- 2hr day - 4hr night

Your being over by 20 minutes at night might be fine for you but in

general is not recommended or suggested.

> >

> >

> >

> > Andy

> >

> > If someone doses ALA and DMSA every 2 h during the daytime and

every 4

> > h at night, would they have to change the dose at night?

> >

> > Like suppose they are taking 25 mg doses of each q 2 h during the

day,

> > what doses would they take q 4 h at night? Or is this not

> recommended?

> >

> > Thanks

> >

> >

> >

>

[Guest guest]

Thanks for the feedback. I see your point about them not being

similar. The problem I had with switching between 3 hrs during the

day and 4 hours at night is that it does not fit into a 24 hour

clock. If you use two 4 hours intervals at night, that leaves 16 hrs

during the day. It can either be 3:12, or 2:40 if you want to dose &

sleep at the same time every day. Since 3:12 is over the limit for

ALA, I went with 2:40. Any comments? Would 3:12 be OK after ALA is

added, or does it depend in individual metabolism, etc.?

-= Alan

> > >

> > >

> > >

> > > Andy

> > >

> > > If someone doses ALA and DMSA every 2 h during the daytime and

> every 4

> > > h at night, would they have to change the dose at night?

> > >

> > > Like suppose they are taking 25 mg doses of each q 2 h during

the

> day,

> > > what doses would they take q 4 h at night? Or is this not

> > recommended?

> > >

> > > Thanks

> > >

> > >

> > >

> >

>

[Guest guest]

Thanks TK. Sorry about the awkward way I worded the question. It

came from people in other groups asking about dosing at 2 h intervals

in the daytime and I didn't know what those people would do at night.

> >

> >

> >

> > Andy

> >

> > If someone doses ALA and DMSA every 2 h during the daytime and every 4

> > h at night, would they have to change the dose at night?

> >

> > Like suppose they are taking 25 mg doses of each q 2 h during the day,

> > what doses would they take q 4 h at night? Or is this not

> recommended?

> >

> > Thanks

> >

> >

> >

>

[Guest guest]

TK--- they would need to stay at 2hr or could possibly go to 3hr for

the two night doses.

> > >

> > >

> > >

> > > Andy

> > >

> > > If someone doses ALA and DMSA every 2 h during the daytime and

every 4

> > > h at night, would they have to change the dose at night?

> > >

> > > Like suppose they are taking 25 mg doses of each q 2 h during

the day,

> > > what doses would they take q 4 h at night? Or is this not

> > recommended?

> > >

> > > Thanks

> > >

> > >

> > >

> >

>