Re: Re:OT? - natural metal chelation enzymes? (nomally present in humans)

[Guest guest]

What is the relation between glutation and the glutathion

peroxidases? Owen posted to the SulfurStories list that some

problems migh be caused by the body substituting selenium in the

various sulfur processing pathways, which then doesn't leave enough

Se for the things it really needs to do (such as the GPx enzymes),

which sulfur can't do (or won't easily - I'm not a biochemist - yet

anyway, and I figure that figuring out when and how well one atom

would substitute for another might go into the realm of biochemical-

physics..)

> Glutathione. It can be bought as a supplement. Speculation is, at

> least some autistic kids don't make enough of it.

>

It would seem this would be pretty easy to test - depending on

where the glutathione (GSSG ?) was in the body (the blood - easy to

assey, anywhere else - hard) Of course, if the GSSG was there, but

some co-factor isn't working.. Which it probably is, as autism seems

to be increasing, which rules out a simple pure genetic factor.

Jim

[Guest guest]

Jim,

Take a look at this as a nice description of what glutathione peroxidase

does: http://en.wikipedia.org/wiki/Glutathione_peroxidase

Basically, this enzyme uses glutathione to protect us from oxidative

damage. It is a molecule that contains selenocysteine in its active

site Selenocysteine is just like cysteine except instead of the sulfur, it

contains selenium.

When selenium is scarce, the enzyme cannot form at normal rates because it

is dependent on that supply of selenium.

Do you think I should cross-post what I put on sulfurstories?

At 08:07 PM 1/28/2008, you wrote:

>What is the relation between glutation and the glutathion

>peroxidases? Owen posted to the SulfurStories list that some

>problems migh be caused by the body substituting selenium in the

>various sulfur processing pathways, which then doesn't leave enough

>Se for the things it really needs to do (such as the GPx enzymes),

>which sulfur can't do (or won't easily - I'm not a biochemist - yet

>anyway, and I figure that figuring out when and how well one atom

>would substitute for another might go into the realm of biochemical-

>physics..)

> > Glutathione. It can be bought as a supplement. Speculation is, at

> > least some autistic kids don't make enough of it.

> >

>It would seem this would be pretty easy to test - depending on

>where the glutathione (GSSG ?) was in the body (the blood - easy to

>assey, anywhere else - hard) Of course, if the GSSG was there, but

>some co-factor isn't working.. Which it probably is, as autism seems

>to be increasing, which rules out a simple pure genetic factor.

>

>Jim

>

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