Too much Mercury - liver stress - fructose intolerance?

[Guest guest]

I was wondering whether too much mercury in the body

makes the liver really stressed? I am sure the answer

will be yes, but I don't understand how exactly.

I understand that too much mercury causes oxidative

stress. For this we can take vitamin C and E.

I ask this because I have problems with fructose and

I notice feeling better if I avoid fructose completely.

It's definitely feeding the bad bacteria in the gut

(Glut 5 deficiency?). But it is also giving me hypogly-

cemia.

I have also noticed that my blood clotting isn't really

good. It does clot, but it happens slowly and the crust

that is produced is weak.

Also my blood (total)cholesterol level is low and I have

read that the liver makes cholesterol. It seems mine isn't

really, probably because it is having difficulty with

detoxing.

I have had a lot of digestive issues, food allergies, celiac

disease. Also this year quite some stress. I am quite sure

this stress has accumulated in the liver too.

I am sure once the emotional thing is completely resolved, I

will be better, but I think there is probably something bio-

chemically going wrong in my body.

I know 100% for sure that I can't handle copper from food very

well. When I eat too much nuts, I get pain in the liver(low

ceruloplasmin? adrenal fatigue is something I definitely have)

I have been taking zinc in high dosages for almost 1.5 years,but

I understand that as long as the adrenal fatigue is not resolved

that I will keep this copper problem.

I am 24 now. When I was 16, I became very jellow. I got x rays,

blood tests everything. No liver problems they said, but I did

have high bilirubine. Diagnosis, Gilbert Syndrome. Well I haven't

been yellow since that time. I am sure this Gilbert Syndrome diag-

nosis is incorrect and it is probably my liver not being able to

detoxify for another reason.

At that time I did not know I had celiac disease. So probably that

would be a reason. But now I eat very healthy(SCD diet)

and don't have any allergic responses. Still feel fatigued, reactive

hypoglycemia,

low cholesterol, skinny, cold body.

Anyone have ideas about my situation?

[Guest guest]

Ali,

When you cut and paste small pieces of text and send to the group would you

please include the source - the citation or the URL. If there is no source

sited the message can be rejected.

J

moderator

About the fructose intolerance and liver

stress/mercury excess I found this:

''Fructose

A study of 11 adult men found that a diet high in fructose

20% of total calories) resulted in increased urinary loss

of phosphorus and a negative phosphorus balance (i.e.,

daily loss of phosphorus was higher than daily intake).

This effect was more pronounced when the diet was also

low in magnesium (3). A potential mechanism for this effect

is the lack of feedback inhibition of the conversion of

fructose to fructose-1-phosphate in the liver. In other

words, fructose-1-phosphate accumulates in the cell but this

compound does not inhibit the enzyme that phosphorylates fructose,

which consumes large amounts of phosphate. This phenomenon is

known as phosphate trapping (1). This study's finding is relevant

because fructose consumption in the U.S. has been increasing

rapidly since the introduction of high fructose corn syrup in

1970, while magnesium intake has decreased over the past century.

And this:

''# Many proteins need to have phosphorus derivatives attached

to them, and mercury will get in the way of this. This may explain

, at least to some degree, the incredible fatigue mercury patients

experience. The molecule in your body responsible for energy –ATP-

looses a phosphate group when you use it and becomes ADP. Then

another phosphate must be added to " refurbish " it to ATP, so your

body can reuse it and mercury gets in the way of this.''

Does this explain why fructose is not tolerated well by the liver?

I understand from this that the liver needs phosphate to convert

fructose to glucose. That when there is too much mercury, ADP can't

be made ATP again.

I unfortunately don't really understand these biochemical

processes.Also pyridoxal phosphate seems to be very important for

fructose handling by the liver. Well I have problems with zinc-

copper and zinc/magnesium are very important for pyridoxal phos-

phate production.

Could somebody with a better biochemical knowledge explain this

to me. Why I am having problems with fructose, why mercury can

be causing this?

I thank you in advance.

Greetings Ali

[Guest guest]

I don't know but I presume its mercury, I have the fructose issue

confirmed by a hydrogen breath test. Copper too high and adrenals not

quite 100%. Been chelating 1.5 yrs. Gut getting much better though

with carbs before I could not tolerate carbs either.

Phil

>

> I was wondering whether too much mercury in the body

> makes the liver really stressed? I am sure the answer

> will be yes, but I don't understand how exactly.

>

> I understand that too much mercury causes oxidative

> stress. For this we can take vitamin C and E.

>

> I ask this because I have problems with fructose and

> I notice feeling better if I avoid fructose completely.

> It's definitely feeding the bad bacteria in the gut

> (Glut 5 deficiency?). But it is also giving me hypogly-

> cemia.

>

> I have also noticed that my blood clotting isn't really

> good. It does clot, but it happens slowly and the crust

> that is produced is weak.

>

> Also my blood (total)cholesterol level is low and I have

> read that the liver makes cholesterol. It seems mine isn't

> really, probably because it is having difficulty with

> detoxing.

>

> I have had a lot of digestive issues, food allergies, celiac

> disease. Also this year quite some stress. I am quite sure

> this stress has accumulated in the liver too.

>

> I am sure once the emotional thing is completely resolved, I

> will be better, but I think there is probably something bio-

> chemically going wrong in my body.

>

> I know 100% for sure that I can't handle copper from food very

> well. When I eat too much nuts, I get pain in the liver(low

> ceruloplasmin? adrenal fatigue is something I definitely have)

>

> I have been taking zinc in high dosages for almost 1.5 years,but

> I understand that as long as the adrenal fatigue is not resolved

> that I will keep this copper problem.

>

> I am 24 now. When I was 16, I became very jellow. I got x rays,

> blood tests everything. No liver problems they said, but I did

> have high bilirubine. Diagnosis, Gilbert Syndrome. Well I haven't

> been yellow since that time. I am sure this Gilbert Syndrome diag-

> nosis is incorrect and it is probably my liver not being able to

> detoxify for another reason.

>

> At that time I did not know I had celiac disease. So probably that

> would be a reason. But now I eat very healthy(SCD diet)

> and don't have any allergic responses. Still feel fatigued, reactive

> hypoglycemia,

> low cholesterol, skinny, cold body.

>

> Anyone have ideas about my situation?

>

[Guest guest]

Ali

Gilberts syndrome is diagnosed by high bilirubin with normal liver

enzymes. If you were yellow, and you had all those tests, it is

likely that that is what you have. I have it too, and I had the same

symptom set as you - low cholesterol, reactive hypoglycemia, skinny,

cold, frequent liver pains, problems making blood sugar, generally

sluggish liver. Gilberts is supposedly a genetic, ie, inherited

condition, but neither of my parents have it. I believe it is down

to mercury damage of the phase 2 pathway, which is the pathway which

detoxifies heavy metals. My Gilberts is acquired, and has been

caused by mercury.

The thing that can help a lot is proper thyroid treatment.

Conversion of T4 to T3 also takes place down the phase 2 pathway,

which is sluggish in Gilberts people. I believe you will likely need

to supplement with Armour or T3 thyroid hormone to imrpvoe the

efficiency of your liver, and raise body temperature. For me, taking

the right level of thyroid hormone (a tricky business)has also

resolved the reactive hypoglycemia (which I thought I had, but which

is actually gastroparesis - slow stomach emptying, which messes up

blood sugar).

You mention a problem with fructose. Give the blood sugar problems

that Gilberts people seem to have, I think it makes sense to avoid

all forms of sugar and reduce the burden on your liver. I also take

milk thistle to support the liver, but not sure if this is doing

anything.

Loads more information about Gilberts here www.gilbertssyndrome.com

Seems we will have a harder time getting rid of the mercury than

other people. Sigh :-((((

Nicola

>

> I was wondering whether too much mercury in the body

> makes the liver really stressed? I am sure the answer

> will be yes, but I don't understand how exactly.

>

> I understand that too much mercury causes oxidative

> stress. For this we can take vitamin C and E.

>

> I ask this because I have problems with fructose and

> I notice feeling better if I avoid fructose completely.

> It's definitely feeding the bad bacteria in the gut

> (Glut 5 deficiency?). But it is also giving me hypogly-

> cemia.

>

> I have also noticed that my blood clotting isn't really

> good. It does clot, but it happens slowly and the crust

> that is produced is weak.

>

> Also my blood (total)cholesterol level is low and I have

> read that the liver makes cholesterol. It seems mine isn't

> really, probably because it is having difficulty with

> detoxing.

>

> I have had a lot of digestive issues, food allergies, celiac

> disease. Also this year quite some stress. I am quite sure

> this stress has accumulated in the liver too.

>

> I am sure once the emotional thing is completely resolved, I

> will be better, but I think there is probably something bio-

> chemically going wrong in my body.

>

> I know 100% for sure that I can't handle copper from food very

> well. When I eat too much nuts, I get pain in the liver(low

> ceruloplasmin? adrenal fatigue is something I definitely have)

>

> I have been taking zinc in high dosages for almost 1.5 years,but

> I understand that as long as the adrenal fatigue is not resolved

> that I will keep this copper problem.

>

> I am 24 now. When I was 16, I became very jellow. I got x rays,

> blood tests everything. No liver problems they said, but I did

> have high bilirubine. Diagnosis, Gilbert Syndrome. Well I haven't

> been yellow since that time. I am sure this Gilbert Syndrome diag-

> nosis is incorrect and it is probably my liver not being able to

> detoxify for another reason.

>

> At that time I did not know I had celiac disease. So probably that

> would be a reason. But now I eat very healthy(SCD diet)

> and don't have any allergic responses. Still feel fatigued, reactive

> hypoglycemia,

> low cholesterol, skinny, cold body.

>

> Anyone have ideas about my situation?

>

[Guest guest]

Hi Ali,

In biomed autism circles, the studies have indicated that mercury

toxic people have had many digestive enzymes systems inactivated,

thus they do not tolerate disaccharides/starches well, but glucose

seems to be tolerated. Off the top of my head the researchers are

Pfeiffer Institute/Bill Walsh and those mob.

The autism kids sometimes use (parents decision you know)

supplementary enzymes to help with this issue, plus of course

limiting those foods in the first place to minimise the ill-effects.

Think the company who sells them in USA is Houston Enzymes/Kirkmans.

Look those up and see what info you can find. Some families find one

company's works for their child, and the other companies don't.

They also have a product called " NO Phenol " that apparently helps

dealing with phenols in foods.

I just use normal enzymes with a bit of each (carb/fat/protein) for

my son at present.

na

>

>

> Ali,

>

> When you cut and paste small pieces of text and send to the group

would you please include the source - the citation or the URL. If

there is no source sited the message can be rejected.

>

> J

> moderator

>

>

>

> About the fructose intolerance and liver

> stress/mercury excess I found this:

>

> ''Fructose

>

> A study of 11 adult men found that a diet high in fructose

> 20% of total calories) resulted in increased urinary loss

> of phosphorus and a negative phosphorus balance (i.e.,

> daily loss of phosphorus was higher than daily intake).

> This effect was more pronounced when the diet was also

> low in magnesium (3). A potential mechanism for this effect

> is the lack of feedback inhibition of the conversion of

> fructose to fructose-1-phosphate in the liver. In other

> words, fructose-1-phosphate accumulates in the cell but this

> compound does not inhibit the enzyme that phosphorylates fructose,

> which consumes large amounts of phosphate. This phenomenon is

> known as phosphate trapping (1). This study's finding is relevant

> because fructose consumption in the U.S. has been increasing

> rapidly since the introduction of high fructose corn syrup in

> 1970, while magnesium intake has decreased over the past century.

>

> And this:

>

> ''# Many proteins need to have phosphorus derivatives attached

> to them, and mercury will get in the way of this. This may explain

> , at least to some degree, the incredible fatigue mercury patients

> experience. The molecule in your body responsible for energy –ATP-

> looses a phosphate group when you use it and becomes ADP. Then

> another phosphate must be added to " refurbish " it to ATP, so your

> body can reuse it and mercury gets in the way of this.''

>

> Does this explain why fructose is not tolerated well by the liver?

>

> I understand from this that the liver needs phosphate to convert

> fructose to glucose. That when there is too much mercury, ADP can't

> be made ATP again.

>

> I unfortunately don't really understand these biochemical

> processes.Also pyridoxal phosphate seems to be very important for

> fructose handling by the liver. Well I have problems with zinc-

> copper and zinc/magnesium are very important for pyridoxal phos-

> phate production.

>

> Could somebody with a better biochemical knowledge explain this

> to me. Why I am having problems with fructose, why mercury can

> be causing this?

>

> I thank you in advance.

>

> Greetings Ali

>

[Guest guest]

>

>

> Ali,

>

> When you cut and paste small pieces of text and send to the group

would you please include the source - the citation or the URL. If

there is no source sited the message can be rejected.

>

> J

> moderator

>

>

>

>

>

Thanks for the advise . Hopefully I won't forget to

give the links in the future.

Greetings Ali

[Guest guest]

>

> Ali

>

> Gilberts syndrome is diagnosed by high bilirubin with normal liver

> enzymes. If you were yellow, and you had all those tests, it is

> likely that that is what you have. I have it too, and I had the same

> symptom set as you - low cholesterol, reactive hypoglycemia, skinny,

> cold, frequent liver pains, problems making blood sugar, generally

> sluggish liver. Gilberts is supposedly a genetic, ie, inherited

> condition, but neither of my parents have it. I believe it is down

> to mercury damage of the phase 2 pathway, which is the pathway which

> detoxifies heavy metals. My Gilberts is acquired, and has been

> caused by mercury.

>

> The thing that can help a lot is proper thyroid treatment.

> Conversion of T4 to T3 also takes place down the phase 2 pathway,

> which is sluggish in Gilberts people. I believe you will likely need

> to supplement with Armour or T3 thyroid hormone to imrpvoe the

> efficiency of your liver, and raise body temperature. For me, taking

> the right level of thyroid hormone (a tricky business)has also

> resolved the reactive hypoglycemia (which I thought I had, but which

> is actually gastroparesis - slow stomach emptying, which messes up

> blood sugar).

>

> You mention a problem with fructose. Give the blood sugar problems

> that Gilberts people seem to have, I think it makes sense to avoid

> all forms of sugar and reduce the burden on your liver. I also take

> milk thistle to support the liver, but not sure if this is doing

> anything.

>

> Loads more information about Gilberts here www.gilbertssyndrome.com

>

> Seems we will have a harder time getting rid of the mercury than

> other people. Sigh :-((((

>

Thank you for this information.

I did get yellow when I was 16 or so. Then it went away and I have

never been yellow again. My bilirubin levels have been retested

a few times and they were always normal.

I am now 24 and approximately 2.5-3 years ago learned that I had

this celiac disease. I think that having celiac disease for like

20 years without knowing it has made my liver weak. The leaky

gut has I think made me accumulate heavy metals which a strong

intestinal barrier would have prevented.

I believe I can solve this weak liver issue by chelation and

relaxation and proper diet. It has taken so many years to

weaken my liver, so it will probably take some time before

the damage is undone 100%(if that is possible).

The thing that makes me wonder about fructose is whether

I might have hereditary fructose intollerance. I definitely

have intestinal problems with fructose, but that could just

be fructose malabsorption. However I also have hypoglycemia.

Of course it could be that my liver simply is so busy

detoxing, it is not strong enough to make glucose out

of fructose.

Nicola I only have liver pain, when I eat a lot of nuts which

are high in copper. Probably because of my adrenal fatigue=

low ceruloplasmin.

According to Mr Kamsteeg(HPU disease) the enzyme aldolase

B is dependenton zinc. I have been supplementing zinc in

quite high dosages for over 1.5 years now.

I know for certain that because of my stress and adrenal

fatigue, I am probably flushing the zinc out very quickly.

Low zinc and magnesium=low pyridoxal phosphate which

is very important for picolinic acid production which in

its turn is very important for absorption of zinc, magne-

sium, chromium.

I think I might be low in MT(metallotothein spelling?)which

is very important for zinc/gut healing.

Nicola, I have the feeling that my gastric emptying is much

too quick! I did have a test to check this, but according to

the doctor, stomach emptying was normal.

I think that when fructose is not made into glucose, because

the liver can't(for whatever reason)it builds up. Therefore

there probably is too much insulin in the body constantly

which messes up digestion.

I am now trying a diet which has no fructose at all. Could

it be that fructose is only handled correctly by the liver

when it is working very well?

About my thyroid. I have TSH, Free T3 tested. And they were

normal. Is it possible that the body has become desensitized

to thyroid hormone? So while the levels are ok, the desensi-

tization makes one still deficient?

I never had fillings, so no amalgam ever in my mouth. The

cause for me is probably a leaky gut from celiac disease

which I had for 20 years before I found out about it.

Nicola I have started my 3 round of ALA. I have also added

smal amounts of NAC to improve detoxification. When I took

NAC, MSM vitamin C and vitamin E without ALA I got a major

headache(redistribution probably). Now that I use ALA along

I have no such issue. I did get a nightmare yesterday.

I also take minerals because I feel them getting depleted

when I use ALA.

Hope you are doing well.

Greetings Ali

[Guest guest]

>

> I was wondering whether too much mercury in the body

> makes the liver really stressed? I am sure the answer

> will be yes, but I don't understand how exactly.

>

The liver has a huge variety of jobs to do. Most of these jobs

require enzyme reactions and mercury interferes with enzymes.

> I understand that too much mercury causes oxidative

> stress. For this we can take vitamin C and E.

>

> I ask this because I have problems with fructose and

> I notice feeling better if I avoid fructose completely.

> It's definitely feeding the bad bacteria in the gut

> (Glut 5 deficiency?). But it is also giving me hypogly-

> cemia.

>

Through google I found two possibilities - Hereditary fructose

intolerance (http://en.wikipedia.org/wiki/Fructose_intolerance) and

Fructose malabsorption

(http://en.wikipedia.org/wiki/Fructose_malabsorption).

> I have also noticed that my blood clotting isn't really

> good. It does clot, but it happens slowly and the crust

> that is produced is weak.

>

> Also my blood (total)cholesterol level is low and I have

> read that the liver makes cholesterol. It seems mine isn't

> really, probably because it is having difficulty with

> detoxing.

>

> I have had a lot of digestive issues, food allergies, celiac

> disease. Also this year quite some stress. I am quite sure

> this stress has accumulated in the liver too.

>

> I am sure once the emotional thing is completely resolved, I

> will be better, but I think there is probably something bio-

> chemically going wrong in my body.

>

> I know 100% for sure that I can't handle copper from food very

> well. When I eat too much nuts, I get pain in the liver

What makes you think that it is the copper in the nuts and not the fat

that is leading to liver pain? Have you tried things like lecithin to

emulsify fats, milk thistle to increase bile flow, or even ox bile to

add some extra bile?

(low

> ceruloplasmin? adrenal fatigue is something I definitely have)

>

> I have been taking zinc in high dosages for almost 1.5 years,but

> I understand that as long as the adrenal fatigue is not resolved

> that I will keep this copper problem.

>

What evidence do you have that there is a copper problem? Did you

have high copper on a hair test?

Do you take the supplements that Andy recommends for high copper?

> I am 24 now. When I was 16, I became very jellow. I got x rays,

> blood tests everything. No liver problems they said, but I did

> have high bilirubine. Diagnosis, Gilbert Syndrome. Well I haven't

> been yellow since that time. I am sure this Gilbert Syndrome diag-

> nosis is incorrect and it is probably my liver not being able to

> detoxify for another reason.

>

> At that time I did not know I had celiac disease. So probably that

> would be a reason. But now I eat very healthy(SCD diet)

> and don't have any allergic responses.

>Still feel fatigued, reactive

> hypoglycemia,

> low cholesterol, skinny, cold body.

>

> Anyone have ideas about my situation?

>

Did you have a hair test and post your results?

Have you had your adrenals and thyroid tested?

J