Guest guest Posted May 2, 2010 Report Share Posted May 2, 2010 I will try that dosing schedule. 3 quick questions: If I take iron, how far either side of the SRt3 should I take it to prevent it binding? In your experience will my symptoms clear/improve before the Rt3 clears? How do I find out about getting cynamol from Mexico if I decide to go down that path? > > > > >Thanks for all the information, I will talk to my Doc about straight T3, but am not hopeful. I was not on anything else before SRt3, had very low ferritin (22) due to another illness, but have managed to get that up. If I have to remain on SRt3 how often do you think it is safe to increase and by how much each time, should I try 20mcg every 8 hours for my next increase? > > That seems a reasonable increase going over to 8 hour intervals. > > You need to be more cautious about SR than you do normal as an > overdose stays with you longer so you can't dose to " a bit too much > and then back off a notch " . > > Assuming the 20 of SR is similar to 12.5 or 15 of normal you can add > extra doses 1 at a time for increases. > > If you go over to 3 times a day and then start adding an extra to one > of those doses at a time so you go from > > 20, 20 to > > 20, 20, 20 > > and then > > 40, 20, 20 > > 40 40 20 > > 40, 40, 40 > > 60, 40 40 > > and increase like that at something like weekly intervals bearing in > mind temperature, pulse etc as per the web site > > Nick > > -- > > for more information on RT3 and Thyroid Resistance go to > > www.thyroid-rt3.com > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 2, 2010 Report Share Posted May 2, 2010 Nick, I saw your response to this and wanted to ask you a question about the dosing. Don't mean to take over the thread, but I also take SR 3 x/day and seems to be working for me just fine so far, but when I increase I have tried to split the increase between all 3 doses as much as possible as my adrenals prefer this. :-) I have been increasing by only 10, though. So for example, I am now at 35, 35, 35. And was going to bump to 40, 40, 35 next. BUT I have a weird problem that my basals are too high compared to my daily averages. I am not hyper in the least, in fact, I feel hypo still. No high pulse or high temps, just high basals. I wonder if I am taking too much at bedtime and maybe need to stop raising the bedtime (or even lower it) and just increase the am and afternoon dose. I notice people here who take cynomel don't take 1/4 their dose at bedtime as far as I can tell. I mean, you personally only take 25 at bed, right, and spread the other 100 over the day? So only 25 to cover you for the entire night but 100 to cover the daytime. But I'm not sure because I know t3 is pretty constant throughout 24 hours in healthy people. Thanks for any advice. Kathleen > Assuming the 20 of SR is similar to 12.5 or 15 of normal you can add > extra doses 1 at a time for increases. > > If you go over to 3 times a day and then start adding an extra to one > of those doses at a time so you go from > > 20, 20 to > > 20, 20, 20 > > and then > > 40, 20, 20 > > 40 40 20 > > 40, 40, 40 > > 60, 40 40 > > and increase like that at something like weekly intervals bearing in > mind temperature, pulse etc as per the web site > > Nick > > -- > > for more information on RT3 and Thyroid Resistance go to > > www.thyroid-rt3.com > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 2, 2010 Report Share Posted May 2, 2010 Hi, I take SR and iron and calcium and find it's easier to fit in with the SR actually. I take the SR AM and then iron 3 hours later and then I take my afternoon dose of SR around 3 or 4, and take more iron with dinner (which I eat at 7), then calcium after dinner, which still leaves about 4 hours until the bedtime dose. So basically if you take the iron/calcium at lunch it is 3 hours from the am dose and if you take more iron/calcium at dinner, it should also end up being 3 hours from your mid afternoon dose. So it fits in pretty easily I think! :-) Another girl here who also successfully takes SR says the pharmacist told her that the SR stays ahead of whatever you eat/supp in the digestive tract, and I have not noticed any issues of my supps binding my t3 by doing it this way. If you post again for the cynomel sources, the mods should email it to you privately. Let me know how the SR works for you if you do it. I know many here don't like it and it got a bad rap, but it works for me and some others, too, and is more convenient to take IMO. If it is less potent, then I will just end up taking more, so I figure that doesn't really matter ultimately. The only downside is the cost of course and whether your doc will let you go up high enough. Luckily, the latter isn't an issue for me. And it's not horridly expensive once you figure out your dose because they charge almost the same for the pills whether they are 40 mcg or 5 mcg!! But I would love to hear other's experiences that it works for. Kathleen > > > > > > > >Thanks for all the information, I will talk to my Doc about straight T3, but am not hopeful. I was not on anything else before SRt3, had very low ferritin (22) due to another illness, but have managed to get that up. If I have to remain on SRt3 how often do you think it is safe to increase and by how much each time, should I try 20mcg every 8 hours for my next increase? > > > > That seems a reasonable increase going over to 8 hour intervals. > > > > You need to be more cautious about SR than you do normal as an > > overdose stays with you longer so you can't dose to " a bit too much > > and then back off a notch " . > > > > Assuming the 20 of SR is similar to 12.5 or 15 of normal you can add > > extra doses 1 at a time for increases. > > > > If you go over to 3 times a day and then start adding an extra to one > > of those doses at a time so you go from > > > > 20, 20 to > > > > 20, 20, 20 > > > > and then > > > > 40, 20, 20 > > > > 40 40 20 > > > > 40, 40, 40 > > > > 60, 40 40 > > > > and increase like that at something like weekly intervals bearing in > > mind temperature, pulse etc as per the web site > > > > Nick > > > > -- > > > > for more information on RT3 and Thyroid Resistance go to > > > > www.thyroid-rt3.com > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 3, 2010 Report Share Posted May 3, 2010 >Nick, I saw your response to this and wanted to ask you a question about the dosing. Don't mean to take over the thread, but I also take SR 3 x/day and seems to be working for me just fine so far, but when I increase I have tried to split the increase between all 3 doses as much as possible as my adrenals prefer this. :-) I have been increasing by only 10, though. > >So for example, I am now at 35, 35, 35. And was going to bump to 40, 40, 35 next. As she had it in doses of 20 I suggested it based on that, if there are 10s as well then it's easier to keep it even. by the nature of SR if you are taking before the previous dose runs out then it evens things out Nick -- for more information on RT3 and Thyroid Resistance go to www.thyroid-rt3.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 3, 2010 Report Share Posted May 3, 2010 > >BUT I have a weird problem that my basals are too high compared to my daily averages. I am not hyper in the least, in fact, I feel hypo still. No high pulse or high temps, just high basals. I wonder if I am taking too much at bedtime and maybe need to stop raising the bedtime (or even lower it) and just increase the am and afternoon dose. Sounds like high night time cortisol to me, how are your adrenals?? On the basis that T3 levels are relatively constant through 24 hours it makes sense to me that the cortisol cycle is the one that causes the night time temperature drop in normal people, we know that cortisol affects temperature > >I notice people here who take cynomel don't take 1/4 their dose at bedtime as far as I can tell. I mean, you personally only take 25 at bed, right, and spread the other 100 over the day? So only 25 to cover you for the entire night but 100 to cover the daytime. I have been on 150 since the autumn and take 25 as a " lights out dose " I don't feel hypo on waking and am getting good quality sleep waking feeling refreshed before the alarm goes off. My working theory is that the consumption of T3 is low at night, the cortisol is transporting less T3 into the cells so less gets used up. My night time dose seems to last 7 hours without a problem. My working theory is that there is something that controls the mechanism by which T3 is taken into the cells by cortisol. If I have a high daytime T3 level (I tried taking the same amount of T3 in less doses) then my cortisol production can't keep up and I get low adrenal symptoms, a temperature drop, and severe fatigue. At night when cortisol is lower I can cope with the amount of T3 I take in the morning when cortisol is high, there has to be some mechanism for regulating what is going on with T3 and cortisol. Just speculating here Nick -- for more information on RT3 and Thyroid Resistance go to www.thyroid-rt3.com Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 3, 2010 Report Share Posted May 3, 2010 THanks for the quick reply, Nick! > Sounds like high night time cortisol to me, how are your adrenals?? > > On the basis that T3 levels are relatively constant through 24 hours > it makes sense to me that the cortisol cycle is the one that causes > the night time temperature drop in normal people, we know that > cortisol affects temperature Per a phone consult with Val, I just raised my HC due to the symptoms I was having during the day. She, too, wondered if maybe I have high nightime cortisol but said that might change once I increased my HC throughout the day. I have no other way really to tell if my nighttime cortisol is high. I can't test since I am on HC. I can tell you that if I take a bedtime dose of HC, my basals go even higher, so I suspect you're right that it's high night cortisol causing the high basals. > > I have been on 150 since the autumn and take 25 as a " lights out dose " > > I don't feel hypo on waking and am getting good quality sleep waking > feeling refreshed before the alarm goes off. > > My working theory is that the consumption of T3 is low at night, the > cortisol is transporting less T3 into the cells so less gets used up. > My night time dose seems to last 7 hours without a problem. > > My working theory is that there is something that controls the > mechanism by which T3 is taken into the cells by cortisol. This is what I mean. You take 1/5 your dose at bedtime and that's all you need. I am taking 1/3 my total dose at bed. I wonder if that's more than I need at night, although it should still be there floating around in my blood to be used the next morning. :-) I just hope this doesn't skew my test results by taking 1/3 my dose at night; it might make my labs look falsely high if you see what I mean. > > If I have a high daytime T3 level (I tried taking the same amount of > T3 in less doses) then my cortisol production can't keep up and I get > low adrenal symptoms, a temperature drop, and severe fatigue. > > At night when cortisol is lower I can cope with the amount of T3 I > take in the morning when cortisol is high, there has to be some > mechanism for regulating what is going on with T3 and cortisol. This is actually why I take so much at bedtime. I seem to handle it better. I was trying to take more in the AM, but it gave me bad adrenal symptoms, even when trying to split the doses into every 2 hours! Ah well, I guess I'll just carry on and see how I feel and my daily temps and not worry so much about the basals. Kathleen > > -- > > for more information on RT3 and Thyroid Resistance go to > > www.thyroid-rt3.com > Quote Link to comment Share on other sites More sharing options...
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