ESTRACE & V. PAIN (topical)

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DeeTroll wrote: HI MIchelle, Hon I just sent this somewhere else but maybe it'll help with your doctor. Forget it talks about postmenopause, it absolutely helps the skin used topically. *sigh* Dee~ ----- Original Message ----- From: DeeTroll Obstetrics & Gynecology 1999;94:232-237 © 1999 by The American College of Obstetricians and GynecologistsORIGINAL RESEARCHEffect of Vulvovaginal Estrogen on Sensorimotor Response of the Lower Genital Tract: A Randomized Controlled

Trial DAVID C. FOSTER, MD, MPH, MARY PALMER, PhD, RNC and JANE MARKS, RN From the Department of Obstetrics and Gynecology, University of Rochester School of Medicine and Dentistry, Rochester, New York; University of land School of Nursing, Baltimore, land; and The s Hopkins University School of Medicine, Baltimore, land. Objective: To assess the effect of vulvovaginal estrogen on mucocutaneous sensory threshold (pain sensation, dt) and circumvaginal motor strength. Methods: Thirty-nine postmenopausal, hypoestrogenic women with mixed lower-genitourinary-tract complaints were placed in four masked treatment arms by permuted-block randomization for 6 weeks. One group received 'topical' estradiol (E2) *estradiol* cream (as in Estrace) and pelvic muscle biofeedback training/ The second received 'topical' cream and sham E2 biofeedback. The third

received placebo cream and pelvic muscle biofeedback training, The fourth received placebo cream and sham biofeedback. Circumvaginal muscle strength was measured by averaging maximum intravaginal pressure (mmHg) generated over a set of four pelvic muscle contractions. Absolute changes in von Frey threshold (mN) and maximum intravaginal pressure (mmHg) over 4 and 6 weeks were reported as summary measures. Of 39 subjects, 30 completed the study. Results: Topical estradiol cream 'significantly' improved mechanical 'sensitivity' of the vulvar vestibule to von Frey hairs, a -1.2-mN threshold decrease at 4 weeks and a -1.6-mN threshold 'decrease' at 6 weeks compared with placebo cream. Stratification by age showed significantly

greater improvement in mechanical sensitivity in the older age group randomized to estrogen cream and a -5.49-mN threshold reduction. Maximum intravaginal pressures during circumvaginal muscle contraction did 'not' differ between estrogen and placebo cream users (F = 0.00; P = .99). Conclusion: Improved sensation to mechanical stimuli can result from a rapidly acting, ''direct'' effect of 'topical' E2 cream (Estrace) on the vulvar vestibule. *****END OF MESSAGE/REMOVE WHEN REPLYING*****http://groups.yahoo.com/group/VulvarDisordersto search our archive or view our files.***