SchaferAutismReport: Defective Carnitine Metabolism May Play Role In Autism

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From: sarnets-bounces@... On Behalf Of Schafer Autism ReportSent: Wednesday, May 09, 2012 7:02 PMTo: Schafer Autism ReportSubject: Defective Carnitine Metabolism May Play Role In Autism Read this report online Large text, printer versionWednesday, May 9, 2012p Reader Supported. RESEARCHDefective Carnitine Metabolism May Play Role In Autism sciencecodex.com The deletion of part of a gene that plays a role in the synthesis of carnitine – an amino acid derivative that helps the body use fat for energy – may play a role in milder forms of autism, said a group of researchers led by those at Baylor College of Medicine and Texas Children's Hospital. " This is a novel inborn error of metabolism, " said Dr. Arthur Beaudet, chair of molecular and human genetics at BCM and a physician at Texas Children's Hospital, and the senior author of the report that appears online in the Proceedings of the National Academy of Sciences. " How it is associated with the causes of autism is as yet unclear. However, it could point to a means of treatment or even prevention in some patients. " Beaudet and his international group of collaborators believe the gene deletion leads to an imbalance in carnitine in the body. Meat eaters receive about 75 percent of their carnitine from their diet. However, dietary carnitine levels are low in vegetarians and particularly in vegans. In most people, levels of carnitine are balanced by the body's ability to manufacture its own carnitine in the liver, kidney and brain, starting with a modified form of the amino acid lysine. Carnitine deficiency has been identified when not enough is absorbed through the diet or because of medical treatments such as kidney dialysis. Genetic forms of carnitine deficiency also exist, which are caused when too much carnitine is excreted through the kidneys. In this new inborn error, there is a deletion in the second exon – the protein-coding portion of a gene – of the TMLHE gene, which includes the genetic code for the first enzyme in the synthesis of carnitine (TMLHE stands for trimethyllysine epsilon For rest of today's SAR click here:www.sarnet.org/frm/forsar.htm Today's SAR newslist is human compiled and provided through the support of paid subscriptions. - THANK YOU -$35 for 1 year - or free!www.sarnet.org In This Issue: •••••••••RESEARCHDefective Carnitine Metabolism May Play Role In AutismNeurodevelopmental Disorders: How Human Cells 'Hold Hands'Response to First Treatment May Predict Epilepsy's CoursePUBLIC HEALTHFear Fans Flames For Chemical Makers NEWSKinect Cameras Being Used To Help Detect Autism In Children GPS Technology Enhances Quality of Life for Autism Due To Wandering And Safety IssuesOrangutans at Miami Zoo Use iPads to Communicate NY Seeks To Fire 200 Staff For Abusing DisabledPEOPLEMom Melts Crayons To Help Son, Others With Autism 'Schafer Autism Report' Now an App on iPhone, iPadand Droid! DO SOMETHING ABOUT AUTISM NOW. . . Read, then Forward the Schafer Autism Report.$35 for 1 year - or free!www.sarnet.org Hundreds of Local Autism EventsWeb / EverywhereAlabamaAlaskaArizonaArkansasCaliforniaColoradoConnecticutDelawareDistrict of ColumbiaFloridaGeorgiaHawaiiIdahoWeb / EverywhereIllinoisIndianaIowaKansasKentuckyLouisianaMainelandMassachusettsMichiganMinnesotaMississippiMissouriWeb / EverywhereMontanaNebraskaNevada New HampshireNew JerseyNew MexicoNew YorkNorth CarolinaNorth DakotaOhioOklahomaOregonPennsylvaniaWeb / EverywhereRhode IslandSouth CarolinaSouth DakotaTennesseeTexasUtahVermontVirginiaWashingtonWest VirginiaWisconsinWyomingWeb / EverywhereSend your LETTER Now's the perfect time to order your free Puzzle Piece kits and launch an autism awareness campaign in your community. When we raise the funding necessary, ARI will see that important research is done, including the large-scale, independent study of vaccinated vs. unvaccinated children Click here. SAR Back Issues The Autism CommunitySupports the Schafer Autism Report. . . Read, then Forward the Schafer Autism Report.$35 for 1 year - or free!www.sarnet.org Biomedical Treatments for Autism Spectrum DisordersScientific References and Abstractswww.autismbiomed.com Copyright Notice: The above items are copyright protected. They are for our readers' personal education or research purposes only and provided at their request. Articles may not be further reprinted or used commercially without consent from the copyright holders. To find the copyright holders, follow the referenced website link provided at the beginning of each item. Lenny Schafer editor@... The Schafer Autism Report is a non-profit corporation Vol. 16 No. 15 Unsubscribe here: www.sarnet.org/frm/unsub2.htm

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