SchaferAutismReport: Disorder of Neuronal Circuits in Autism Is Reversible, New Study Suggests

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RESEARCH

Disorder of Neuronal Circuits in Autism Is Reversible, New Study

Suggests

Synaptic

networks in brains of rodent models of autism. (Credit: Stephane

Baudouin)

ScienceDaily

— People with autism suffer from a pervasive developmental disorder of

the brain that becomes evident in early childhood. Scheiffele and

Kaspar Vogt, Professors at the Biozentrum of the University of Basel,

have identified a specific dysfunction in neuronal circuits that is

caused by autism. In the journal Science, the scientists also report

about their success in reversing these neuronal changes. These findings

are an important step in drug development for the treatment for autism.

According to current estimates, about

one percent of all children develop an autistic spectrum disorder.

Individuals with autism may exhibit impaired social behavior, rigid

patterns of behavior and limited speech development. Autism is a

hereditary developmental disorder of the brain. A central risk factor

for the development of autism are numerous mutations in over 300 genes

that have been identified, including the gene neuroligin-3, which is

involved in the formation of synapses, the contact junction between

nerve cells.

Loss of neuroligin-3 interferes with

neuronal signal transmission The consequences of neuroligin-3 loss can

be studied in animal models. Mice lacking the gene for neuroligin-3

develop behavioral patterns reflecting important aspects observed in

autism. In collaboration with Roche the research groups from the

Biozentrum at the

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RESEARCH

Disorder of Neuronal Circuits in Autism Is Reversible, New Study

Suggests

Genetic Test Predicts Risk For Autism

Autistic-Like Traits Emerge Early in High-Risk Siblings

Video

Technology Reveals Autism Gait Is Symmetrical

EDUCATION

Cameras in the Classroom a Crusade for Parents of Special-Needs Kids

PEOPLE

California Teacher Accused of Violent Attacks on Autistic Children to

Stand Trial

Mom

Claims Daycare Overdosed Her Son

COMMENTARY

The New DSM-5 Definition Of Autism And Its Impact On Services

Help Needed to Collect Data on the New DSM-5 ASD Criteria

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