Re: To Barb: Bile Duct Obstruction Is Correlated WIth Ductal Cancer, Study Shows

[Guest guest]

Thanks, Barb for this new study and for all your

efforts in bringing the latest on PSC, for the group.

Blessings.

PSC/UC

--- Barb Henshaw wrote:

>

>

> Source:

> <http://www.faseb.org> Federation of American

> Societies for

> Experimental Biology

>

> Date:

> April 29, 2007

>

>

>

> Bile Duct Obstruction Is Correlated WIth Ductal

> Cancer, Study Shows

>

> <http://www.sciencedaily.com> Science Daily - When

> bile duct cancer

> cells were placed in the liver of animals with bile

> duct obstruction,

> they grew more rapidly than identical cells placed

> in animals without

> bile duct obstruction. In fact, half of the total

> liver mass of the rats

> with bile duct obstruction became replaced by cancer

> cells within three

> weeks compared to only 16 percent of that of animals

> without bile duct

> obstruction.

> Perhaps even more important, the cancers metastized

> outside the liver

> (as they frequently do in human patients with

> advanced bile duct cancer)

> only in the animals with bile duct obstruction.

> Virginia Commonwealth University scientist Dr.

> Alphonse Sirica presented

> the findings at Experimental Biology 2007 in

> Washington, DC. His

> presentation, on April 29, is part of the scientific

> program of the

> American Society for Investigative Pathology.

> The bile ducts are tubes that carry bile (a liquid

> secreted by the liver

> that contains cholesterol, bile salts, and waste

> products) from the

> liver to the gallbladder and small intestine. Bile

> duct obstruction has

> long been known to be present in both malignant and

> nonmalignant liver

> disease (jaundice, for example), but before the

> study by Dr. Sirica and

> his colleagues the direct effect of such obstruction

> on bile duct cancer

> cell growth and aggressiveness had not been

> previously investigated.

> These new findings are highly significant for two

> reasons, says Dr.

> Sirica.

> First, they establish an important correlation

> between bile duct

> obstruction and bile duct cancer, suggesting growth

> regulatory

> mechanisms that could be highly significant in the

> progression of the

> cancer and that could become good molecular targets

> for drug therapy.

> Second, they establish a unique preclinical model of

> how bile duct

> cancer in liver progresses that can be used to

> rapidly test and evaluate

> novel molecular treatment strategies.

> Such strategies are badly needed for this

> understudied cancer, adds Dr.

> Sirica. The incidence and mortality of

> cholangiocarcinoma, the primary

> cancer of the bile ducts, is increasing worldwide.

> Some 3,500 new cases

> are now diagnosed annually in the United States.

> Survival rates remain

> dismally low because most patients have advanced

> disease at the time of

> diagnosis and thus are poor candidates for the

> current best treatment,

> surgical resection. Although there are some known

> risk factors for the

> disease (such as primary sclerosing cholangitis),

> the cause of most

> cases remain unknown and the cellular and molecular

> changes that

> accompany the disease have not been well understood.

>

> This study is part of ongoing work in Dr. Sirica's

> laboratory aimed at

> identifying altered growth factor signaling pathways

> in

> cholangiocarcinoma that may be exploited as

> potential molecular targets

> for therapy. Dr. Sirica's co-authors for the

> Experimental Biology 2007

> presentation are Dr. Zichen Zhang, Dr. Toru Asano,

> Dr. Xue-Ning Shen,

> Deanna J. Ward and Dr. Arvind Mahatme. Support for

> the work came from

> the National Cancer Institute, National Institutes

> of Health.

> Barb in Texas - Together in the Fight, Whatever it

> Takes!

> Son Ken (33) UC 91 - PSC 99 Listed 7/21 @ Baylor

> Dallas

>

>

>

________________________________________________________________________________\

____

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[Guest guest]

Thanks, Barb for this new study and for all your

efforts in bringing the latest on PSC, for the group.

Blessings.

PSC/UC

--- Barb Henshaw wrote:

>

>

> Source:

> <http://www.faseb.org> Federation of American

> Societies for

> Experimental Biology

>

> Date:

> April 29, 2007

>

>

>

> Bile Duct Obstruction Is Correlated WIth Ductal

> Cancer, Study Shows

>

> <http://www.sciencedaily.com> Science Daily - When

> bile duct cancer

> cells were placed in the liver of animals with bile

> duct obstruction,

> they grew more rapidly than identical cells placed

> in animals without

> bile duct obstruction. In fact, half of the total

> liver mass of the rats

> with bile duct obstruction became replaced by cancer

> cells within three

> weeks compared to only 16 percent of that of animals

> without bile duct

> obstruction.

> Perhaps even more important, the cancers metastized

> outside the liver

> (as they frequently do in human patients with

> advanced bile duct cancer)

> only in the animals with bile duct obstruction.

> Virginia Commonwealth University scientist Dr.

> Alphonse Sirica presented

> the findings at Experimental Biology 2007 in

> Washington, DC. His

> presentation, on April 29, is part of the scientific

> program of the

> American Society for Investigative Pathology.

> The bile ducts are tubes that carry bile (a liquid

> secreted by the liver

> that contains cholesterol, bile salts, and waste

> products) from the

> liver to the gallbladder and small intestine. Bile

> duct obstruction has

> long been known to be present in both malignant and

> nonmalignant liver

> disease (jaundice, for example), but before the

> study by Dr. Sirica and

> his colleagues the direct effect of such obstruction

> on bile duct cancer

> cell growth and aggressiveness had not been

> previously investigated.

> These new findings are highly significant for two

> reasons, says Dr.

> Sirica.

> First, they establish an important correlation

> between bile duct

> obstruction and bile duct cancer, suggesting growth

> regulatory

> mechanisms that could be highly significant in the

> progression of the

> cancer and that could become good molecular targets

> for drug therapy.

> Second, they establish a unique preclinical model of

> how bile duct

> cancer in liver progresses that can be used to

> rapidly test and evaluate

> novel molecular treatment strategies.

> Such strategies are badly needed for this

> understudied cancer, adds Dr.

> Sirica. The incidence and mortality of

> cholangiocarcinoma, the primary

> cancer of the bile ducts, is increasing worldwide.

> Some 3,500 new cases

> are now diagnosed annually in the United States.

> Survival rates remain

> dismally low because most patients have advanced

> disease at the time of

> diagnosis and thus are poor candidates for the

> current best treatment,

> surgical resection. Although there are some known

> risk factors for the

> disease (such as primary sclerosing cholangitis),

> the cause of most

> cases remain unknown and the cellular and molecular

> changes that

> accompany the disease have not been well understood.

>

> This study is part of ongoing work in Dr. Sirica's

> laboratory aimed at

> identifying altered growth factor signaling pathways

> in

> cholangiocarcinoma that may be exploited as

> potential molecular targets

> for therapy. Dr. Sirica's co-authors for the

> Experimental Biology 2007

> presentation are Dr. Zichen Zhang, Dr. Toru Asano,

> Dr. Xue-Ning Shen,

> Deanna J. Ward and Dr. Arvind Mahatme. Support for

> the work came from

> the National Cancer Institute, National Institutes

> of Health.

> Barb in Texas - Together in the Fight, Whatever it

> Takes!

> Son Ken (33) UC 91 - PSC 99 Listed 7/21 @ Baylor

> Dallas

>

>

>

________________________________________________________________________________\

____

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