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My General Suggestions for starting oral chelation using Andy's

Protocol

Start ROUND 1 of DMSA 12.5mg. Take 12.5mg or less every 4 hours [or

more often 3hr] on the hour, including waking up at night!!!! If you

miss a dose by an hour stop the round and wait at least as many days

as you chelated before you start again. If there are any side effects

monitor these and if too intolerable, stop. A round is 3 days ON and

3 days OFF initially (later you can increase the number of ON days

and OFF). You need to take at least as many days OFF as ON. A

common chelating schedule for DMSA is 7am - 11am - 3pm - 7pm -11pm -

3am. You can also take longer breaks between rounds if necessary to

recuperate.

If no side effects or mild manageable side effects occur then wait

three days or more before you start ROUND 2 DMSA at 12.5mg.

If no side effects or mild manageable side effects occur then do

another ROUND [3 days and 2 nights] of DMSA at 12.5mg. You can

increase your round by a day or two if you are doing well. So on this

round you could chelate for 4-5 days ON.

At this point you can continue for many more rounds of DMSA alone

before adding ALA. This will reduce your body burden before you start

taking mercury out the brain with ALA. This is often the best path to

follow. If you choose to add ALA at this point then, Start ROUND 4

with 12.5mg DMSA and start ALA 12.5mg with each dose. Take both doses

every 3 hours on the hour or more frequently, including waking up at

night. You can stretch it to every 4 hours ONLY at night if it helps

you get a little more sleep, but go back to every 3 hours during the

day. Many people cannot do this as it redistributes too much Hg with

the fluctuation in chelator blood concentration.

If you miss a dose by an hour stop the round and wait at least as

many days that you chelated to start again. Your blood levels of the

chelator will have dropped too much with the late dose. Monitor side

effects especially after adding ALA, if un-manageable or intolerable

stop the round and reduce dose of the next 3-4 rounds.

Or stop the ALA and continue with the DMSA for a day or two depending

on side effects and how DMSA makes you feel on it's own.

[A second option at this point is to raise only the DMSA to 25mg for

ROUND 4,5,6 or more and see how you do on the higher dose before

adding the ALA. Sometimes the jump from 12.5mg to 25mg is too high

and you may need to stick at about 17mg. Andy suggests you should

never increase the dose by more than half of the current dose. Then

add ALA in a later round [7-8 possibly] after you know how you are

doing with the increased DMSA. When using ALA and DMSA together you

can continue DMSA alone for an extra day or more to remove the

intracellular mercury that the ALA pulls to the extracellular spaces.]

If no side effects or few, do another round same dosage, ROUND 5 DMSA

12.5 and ALA at 12.5mg.

If no side effects or few, do another round same dosage, ROUND 6 DMSA

12.5 and ALA at 12.5mg.

If no problems start next round, ROUND 7, and increase ONLY DMSA from

12.5 to [18.5 - 25mg] and ALA 12.5mg. You must only increase one

chelator at a time, so you know what causes what side effects if you

have them.

If no problems do a few more rounds at this dosage, start next round,

ROUND 10-11, DMSA 25mg and increase ALA also to 25mg. Also only

increase the dose of one chelator at a time.

Do NOT increase both together or you won't know which is causing a

problem.

If no problems arise, increase dosage gradually using the same

process above until you find a dosage that is manageable and stick

there for a long time. If problems occur then go back to the previous

manageable dose and stick there for at least few more rounds.

You can also increase the number of days ON if side effects are

stable, especially if you do well or better while chelating. It is ok

to chelate for longer periods if your body can keep up with the side

effects, then have the same time for rest periods. Most can't go

for too long because of lack of sleep due to the interruption of it,

but some can chelate continuously for longer periods. If you a lot

feel better during the rounds you can extend it for a few more days

and see how you do.

I recommend except for experienced persons that really know what they

are doing and have done a lot of oral chelation following the

protocol not to chelate continuously or for really long periods.

DMSA and ALA usually no more than 2 weeks max.

Longer rounds excrete more Mercury and cause less redistribution.

Longer rounds are advised only for those that actually do better

while chelating - for those that have significant side effects while

on round will you need to take as much time off as on. If you do

better while chelating with the DMSA during those longer rounds and

stop to take a break because of lack of sleep etc. then you should

take some time off before starting again, I would suggest at least 4-

5 days.

Most can't do it for extra long periods. This especially true when

you add ALA and are dosing every 3hrs or more often. But with DMPS,

which is taken, every 8 hours (due to its longer half-life) people

can chelate longer or even continuously with low dosages, as you

don't have to wake up to take doses in the middle of the night.

ALA causes less copper to be released rounds causing problems in the

long-term (especially for copper toxic people) so the off-days are

very important to allow the balance to return to your system if you

have problems with copper.

DMPS - Round one 5-10mg every 6-8hr around the clock for 3 days and

nights, the other rules [missing dose etc] are the same as with DMSA

and still apply.

Round 2 & 3 DMPS the same thing.

Round 4 DMPS if everything is going well and no intolerable or bad

side effects increase dosage to 10-15mg.

Round 5,6,7 DMPS same as above.

Round 8 - DMPS & ALA - If at this point you are still doing well or

better add 12.5mg ALA and do another 3-4 rounds.

Round 11,12,13 - DMPS & ALA - Increase DMPS if still doing well to

20mg.

Round 14,15,16 - DMPS & ALA - increase ALA to 18-25mg and see how you

do.

After this point increase dosages of chelators by weight [links

section] and symptoms remembering not to increase by more than 50% of

the dose you are taking.

If you cannot tolerate the ALA when you try to add it just continue

with the DMPS alone, gradually increasing dosage over time and

numbers of rounds to tolerance. If you happen to do better on round

than off an option is to extend the round a few days 4-6 and see how

you do. If you still do better on round at this point try a week or

two, some people can chelate continuously with low doses of DMPS

until they feel they are ready to add some ALA.

ALA Alone use the same dosage as with DMSA above every 3hr or more

often.

I generally recommend that everyone get all basic labs done

[metabolic,chemistry,urinealysis,lipid (VAP) etc. Many of us have

thyroid and adrenal issues and they require supplementation. With

proper testing and supplementation many people feel tremendously

better with just this.

Please !! make sure you read through Moria's site and the rest of the

links section for information - http://home.earthlink.net/~moriam/

Please remember everyone is different and not everything works the

same for everyone. Also these are suggestions/recommendations for

the protocol and not medical advice.