Guest guest Posted August 12, 2007 Report Share Posted August 12, 2007 Clinically, botulinum toxin A blocks the cholinergic innervation of the target tissue. Recently, it has been proved effective not only at a neuromuscular junction but also within parasympathetic or sympathetic neural synapses. Seven women with pain on genitalia that could not be controlled with conventional pain managements were enrolled in this study. Twenty to 40 U of botulinum toxin A were used in each injection. Injection sites were the vestibule, levator ani muscle or the perineal body. Repeat injections were administered every 2 weeks if the patient's symptoms had not fully subsided. In all patients, pain had disappeared with botulinum toxin A injections. Five patients needed to be injected twice; the other two patients needed only one injection. We did not observe complications related to botulinum toxin A injections, such as pain, hemorrhage, infection, muscle paralysis or other complications. The subjective pain score improved from 8.3 to 1.4, and no one has experienced a recurrence (the follow-up period was four to 24 months, with a mean follow-up of 11.6 months). Botulinum toxin A is effective in blocking nociception. Even though further investigation and well-controlled study will be necessary, we suggest that the botulinum toxin therapy would be useful and safe in managing vulvodynia of muscular or neuroinflammatory origins.Get a sneak peek of the all-new AOL.com. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 17, 2007 Report Share Posted September 17, 2007 Great aticle, Carolyn. I especially like the first sentence and (allergy prone) and the descriptions of the autoimmune reactions, etc. It has lots of good links. Thanks, Arline It Pelvic Myoneuropathy, in its most simplified and broadest terms, describes a process in which people of a particular genetic type and often with tense, anxious, and frequently atopic (allergy-prone) dispositions, develop a chronic process in the pelvis that involves muscles, nerves and mast cells. ________________________________________________________________________________\ ____ Be a better Heartthrob. Get better relationship answers from someone who knows. Yahoo! Answers - Check it out. http://answers.yahoo.com/dir/?link=list & sid=396545433 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 17, 2007 Report Share Posted September 17, 2007 Great aticle, Carolyn. I especially like the first sentence and (allergy prone) and the descriptions of the autoimmune reactions, etc. It has lots of good links. Thanks, Arline It Pelvic Myoneuropathy, in its most simplified and broadest terms, describes a process in which people of a particular genetic type and often with tense, anxious, and frequently atopic (allergy-prone) dispositions, develop a chronic process in the pelvis that involves muscles, nerves and mast cells. ________________________________________________________________________________\ ____ Be a better Heartthrob. Get better relationship answers from someone who knows. Yahoo! Answers - Check it out. http://answers.yahoo.com/dir/?link=list & sid=396545433 Quote Link to comment Share on other sites More sharing options...
Guest guest Posted September 17, 2007 Report Share Posted September 17, 2007 Great aticle, Carolyn. I especially like the first sentence and (allergy prone) and the descriptions of the autoimmune reactions, etc. It has lots of good links. Thanks, Arline It Pelvic Myoneuropathy, in its most simplified and broadest terms, describes a process in which people of a particular genetic type and often with tense, anxious, and frequently atopic (allergy-prone) dispositions, develop a chronic process in the pelvis that involves muscles, nerves and mast cells. ________________________________________________________________________________\ ____ Be a better Heartthrob. Get better relationship answers from someone who knows. Yahoo! Answers - Check it out. http://answers.yahoo.com/dir/?link=list & sid=396545433 Quote Link to comment Share on other sites More sharing options...
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