Depression in patients with PBC and PSC.

[Guest guest]

J Hepatol. 2007 Mar 2; [Epub ahead of

print]

Depression in patients with primary biliary cirrhosis and

primary sclerosing cholangitis.

van Os E, van den Broek WW,

Mulder PG, Ter Borg PC, Bruijn JA, van Buuren HR.

Department of Psychiatry, Erasmus Medical Centre, Rotterdam,

The Netherlands.

BACKGROUND/AIMS: Former studies reported a high prevalence of depression in

patients with primary biliary cirrhosis (PBC) and primary sclerosing

cholangitis (PSC). These

studies hypothesized that the presence of depression could explain the fatigue

experienced by these patients. METHODS: Our aim was to

study the prevalence of depression in a Dutch population with PBC and PSC. In addition, to investigate the effects of using an

additional diagnostic structured psychiatric interview, after screening with

the Beck Depression Inventory (BDI), a self-report severity scale instrument

used in former studies. Patients with PBC and PSC

(n=92) completed the BDI. Patients with scores of 10

or higher (n=39) were interviewed using a structured psychiatric interview. Patients with scores lower than 10 were at random (30/53,

57%) also interviewed using a structured psychiatric interview. RESULTS: Of the 92 patients that were included 42% had

depressive symptoms according to the BDI. However, of

these patients only 3.7% had a depressive syndrome according to the DSM-IV

criteria as assessed with the structured psychiatric interview. CONCLUSIONS:

The prevalence of a depressive disorder in patients with PBC and PSC is not

higher than in the general population. Fatigue in

patients with PBC and PSC cannot be explained by depression. PMID: 17399846 [PubMed

- as supplied by publisher]

Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (32) UC 91 - PSC 99 Listed 7/21 @ Baylor Dallas