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This really isn't anything earth shattering. The a-A gradient is very

accurate (within 2-4) when metabolism, perfusion and ventilation are all

adequate. It appears to me that all/most of these patients have perfusion

issues which will make the accuracy much different. Keeping in mind that

the goal of TBI treatment is to maintain adequate CPP then fixing the

perfusion aspect of these patients will fix the inaccuracy with the a-A

gradient and then it is not an issue.

My 2 cents

Lee

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