Re: Tacrolimus and PSC

[Guest guest]

Tacro is very hard on the kidney's. Drink alot of water day so it doesn't lay in your kidney's to long. The doctor told my husband he should drink at least 36oz's of water a day. He had a liver transplat on APril 5, 2005.

Re: Tacrolimus and PSC

has been on Tacro for over a year for his lung transplant. Maybe that's part of the reason for his LFT's having improved over the last several months?? The only side effect I know of for sure is increased blood pressure. But has so much going on, that it's hard to say how much is side effects from meds and how much is isn't.

Ami <rhodesdavid@ insightbb. com> wrote:

Again, I thought this might be of general interest, but it's a pity about the adverse effects!Liver Int. 2007 May;27(4):451- 3.Tacrolimus for the treatment of primary sclerosing cholangitis.Talwalkar JA, Gossard AA, Keach JC, nsen RA, Petz JL, Lindor KD.Division of Gastroenterology & Hepatology, Mayo Clinic College of Medicine, Rochester, MN, USA.Background: Results from a pilot investigation with tacrolimus for primary sclerosing cholangitis (PSC) demonstrated biochemical improvement without excessive drug toxicity. To date, no confirmatory study has been performed. Aims: We sought to determine the safety and efficacy of tacrolimus in PSC. Methods: An open-label, phase II study of tacrolimus 0.05 mg/kg twice daily for 1 year was performed. Target whole-blood concentrations ranged between 3 and 7 ng/ml. Results: A total of 16 patients were enrolled. The median age was 50 years

(range, 28-68), with 31% being women. The median serum alkaline phosphatase was 903 U/l, AST 88 U/l, total bilirubin 0.9 mg/dl, and albumin 3.8 g/dl. Based primarily on drug-related adverse events, only eight (50%) patients completed 1 year of therapy. After 1 year of therapy, however, significant improvements in median serum alkaline phosphatase (903 vs. 483, P=0.0001) and AST levels (88 vs. 78, P=0.002) were observed in these patients. The median tacrolimus level in patients completing 1 year of therapy was 4.0 ng/ml. Drug-related adverse events, however, were responsible for 31% of participants withdrawing from the study. Conclusions: Despite significant improvements in serum alkaline phosphatase, oral tacrolimus is poorly tolerated in patients with PSC. PMID: 17403184.Best regards,Dave (father of (21); PSC 07/03; UC 08/03)

Ami

mom to - 9 yrs - Double Lung Tx 2/26/2006, PSC - Pre-Liver Tx, Central DI, Steroid Induced Diabetes, Hypothyroid, GERD, High BP, ADD, Anemia, Osteopenia, Gastroperesis, Varices

mom to Emma - 13 yrs - Migraines

stepmom to - 14 yrs - ADHD, ODD

~~~~~~~~~~~~ ~~~~~~~~~ ~~~~~~~~~ ~~~~~~~~~ ~~~~~

Be a PS3 game guru.Get your game face on with the latest PS3 news and previews at Yahoo! Games.

Ahhh...imagining that irresistible "new car" smell? Check out

new cars at Yahoo! Autos.