Vestibulitis & Estrogen 'receptors'. !

[Guest guest]

Sending this in for the newbies...keep in mind that the birth control pill can 'block' Estrogen and Testosterone Receptors in the Vulvar skin, which can lead to Vulvar pain...below is a good article sent in the past by our group owner, Dee. Hugs, ChelleDeeTroll wrote: HI all, For those who wonder about Estrogen (Estrace) use in V.pain and recall how I often mention the 'Receptors' both for Estrogen 'and' Testosterone, I thought this might interest you. Another 'chi ching' (well, to me anyway) *grin* Dee~ Am J Obstet Gynecol, August 1, 2003; 189(2): 458-61. Estrogen receptor expression in vulvar vestibulitis syndrome. LJ Eva, AB MacLean, WM Reid, KJ Rolfe, and CW Perrett Department of Obstetrics and Gynecology, Royal Free and University College Medical School (Royal Free Campus), London, United Kingdom. MEDLINE ABSTRACT OBJECTIVE: A pilot study was performed to investigate the relationship between vulvar vestibulitis syndrome and estrogen receptor expression. STUDY DESIGN: Women with a diagnosis of vulvar vestibulitis syndrome had tissue samples taken for vulvar estrogen receptor-alpha expression and this was compared with a control group. RESULTS: The study group showed a ''significant decrease'' in estrogen receptor expression, and 50% of the samples did not exhibit 'any' receptor expression. CONCLUSION: There appears to be a subgroup of women with vulvar vestibulitis syndrome who exhibit abnormal estrogen receptor-alpha expression. This may be helpful in explaining why some women are resistant to medical treatment and may allow treatment to be prescribed more

effectively. (treatment with estrogen as in Estrace cream, DT) MeSH Terms: Adult Case-Control Studies Estrogen Receptor alpha Female Humans Immunohistochemistry Pain Receptors, Estrogen Syndrome Vulvitis PMID: 14520218