itiching

[Guest guest]

hi my daughter is 37 and had blood work done 2 weeks ago they said her

alt phs was a little up normal is 30 to 120 hers were 228 is that

enough to cause itching she had her colon removed 12 years ago and

they say this is were her problems with her liver are coming from she

ulcertive colities before surgery. sharon

[Guest guest]

Everyone is different, but the itcing generally has to do with the

billirubin level being elevated and the bile salts depositing on the

skin. My Alk Phos is over 500 and I did not start the itching until my

billi got elevated.

PSC 5/07 Listed

>

> hi my daughter is 37 and had blood work done 2 weeks ago they said

her

> alt phs was a little up normal is 30 to 120 hers were 228 is that

> enough to cause itching she had her colon removed 12 years ago and

> they say this is were her problems with her liver are coming from she

> ulcertive colities before surgery. sharon

>

[Guest guest]

Everyone is different, but the itcing generally has to do with the

billirubin level being elevated and the bile salts depositing on the

skin. My Alk Phos is over 500 and I did not start the itching until my

billi got elevated.

PSC 5/07 Listed

>

> hi my daughter is 37 and had blood work done 2 weeks ago they said

her

> alt phs was a little up normal is 30 to 120 hers were 228 is that

> enough to cause itching she had her colon removed 12 years ago and

> they say this is were her problems with her liver are coming from she

> ulcertive colities before surgery. sharon

>

[Guest guest]

Hi Melvyn;

Hopefully this article will answer a lot of your questions:

Marschall HU, Wagner M, Zollner G, Fickert P, Diczfalusy U, Gumhold

J, Silbert D, Fuchsbichler A, Benthin L, Grundstrom R, Gustafsson U,

Sahlin S, Einarsson C, Trauner M 2005 Complementary stimulation of

hepatobiliary transport and detoxification systems by rifampicin and

ursodeoxycholic acid in humans. Gastroenterology 129: 476-485.

http://www.ncbi.nlm.nih.gov/pubmed/16083704

Rifampin (rifampicin) activates a nulcear receptor called the

pregnane X receptor (PXR), which then increases the expression of the

enzymes of bile metabolism and bile transport proteins:

Kliewer SA, Willson TM 2002 Regulation of xenobiotic and bile acid

metabolism by the nuclear pregnane X receptor. J. Lipid Res. 43: 359-

364.

http://www.ncbi.nlm.nih.gov/pubmed/11893771

In cholestasis bile flow is not always completely shut down. Indeed

ursodeoxycholic acid can help restore bile flow in early stages of

the disease.

Best regards,

Dave R.