High dose ursodeoxycholic acid for PSC is safe & effective.

[Guest guest]

Ursodeoxycholic acid (UDCA) has

been shown to improve serum liver tests in primary sclerosing

cholangitis (PSC), but controlled trials have shown

inconsistent effects on liver histology, and did not reveal a survival benefit. This pilot, randomised

dose-ranging trial attempted to determine whether further enrichment of the

bile acid pool with UDCA would lead to an improvement in outcome for PSC

patients…… http://www.ncbi.nlm.nih.gov/pubmed/18314215

Barb in Texas - Together in the Fight, Whatever it Takes!

Son Ken (33) UC 91 - PSC 99 - Tx 6/21 & 6/30/07 @ Baylor in Dallas

[Guest guest]

Thanks Barb,

You are always on the look out for good information.

A small study (31 patients)that shows URSO improved lab results and

hence improved the Mayo survival score.

I wish that the 3 recent recurrent PSA studies had looked at URSO use

and rPSC. I wonder if we could ask them to relook at their data

with the URSO question

>

> Ursodeoxycholic acid (UDCA) has been shown to improve serum liver

tests

> in primary sclerosing cholangitis (PSC), but controlled trials have

> shown inconsistent effects on liver histology, and did not reveal a

> survival benefit. This pilot, randomised dose-ranging trial

attempted to

> determine whether further enrichment of the bile acid pool with UDCA

> would lead to an improvement in outcome for PSC patients..

> http://www.ncbi.nlm.nih.gov/pubmed/18314215

>

> Barb in Texas - Together in the Fight, Whatever it Takes!

> Son Ken (33) UC 91 - PSC 99 - Tx 6/21 & 6/30/07 @ Baylor in Dallas

>