Creatinine level

[Guest guest]

Hi All,

In my bloodtests usually creatinine comes out a little below the lower

border. As I understand they are testing creatinine to see if the

level isn't elevated as would happen in a kidney disfunction. Still, I

was wondering if a low creatinine level in the blood (haven't tested

the urine) is associated with something (maybe even PSC itself?)?

Wishing you all the best,

Gerard

[Guest guest]

i have been wondering this very same thing . my daughter's creatinine

is always just below normal too. she was diagnosed with psc 10 yrs ago

and now has cirrhosis.

chris

[Guest guest]

Hi Gerard;

Creatinine is derived from creatine, which is an important component

of muscle. If you are of small stature and have lower than normal

muscle mass (like me!), then your creatine level may be on the low

end of the normal scale, and so your serum creatinine may also be on

the low end of the normal scale. Serum creatinine seems to follow

serum creatine level.

Creatine comes from two sources (in addition to turnover of your own

muscle tissue). 1. Diet (e.g. ingested meat). If you are a vegetarian

or do not each much red meat then this may also cause a reduction in

creatine and creatinine levels. 2. Creatine can be synthesized in the

liver from guanidinoacetic acid. This enzyme reaction also uses S-

adenosylmethionine (SAMe). Liver disease could impair this reaction

by reducing the amount of the enzyme or the amount of available SAMe.

[A sign of a deficiency of SAMe might be elevated serum homocysteine.

Elevated homocysteine could in turn be caused by folate deficiency,

or vitamin B deficiency, or deficiency of glycine betaine .... but

that's another story].

A 100 page review of the creatine and creatinine metabolism can be

found here:

Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism.

Physiol. Rev. 80: 1107-1213.

http://physrev.physiology.org/cgi/content/full/80/3/1107

One web article indicates:

" Causes of low creatinine include small stature, debilitation,

decreased muscle mass, some complex cases of severe hepatic disease.

In advanced liver disease, low creatinine may result from decreased

hepatic production of creatinine and inadequate dietary protein as

well as reduced muscle mass. "

http://www.labcorp.com/datasets/labcorp/html/chapter/mono/pr003900.htm

If you are concerned about the low creatinine, please do talk to your

doctor about possible causes and whether it is of any significance.

Best regards,

Dave

(father of (22); PSC 07/03; UC 08/03)

> In my bloodtests usually creatinine comes out a little below the

lowe border. As I understand they are testing creatinine to see if

the level isn't elevated as would happen in a kidney disfunction.

Still, I was wondering if a low creatinine level in the blood

(haven't tested the urine) is associated with something (maybe even

PSC itself?)?

[Guest guest]

Hi Gerard;

Creatinine is derived from creatine, which is an important component

of muscle. If you are of small stature and have lower than normal

muscle mass (like me!), then your creatine level may be on the low

end of the normal scale, and so your serum creatinine may also be on

the low end of the normal scale. Serum creatinine seems to follow

serum creatine level.

Creatine comes from two sources (in addition to turnover of your own

muscle tissue). 1. Diet (e.g. ingested meat). If you are a vegetarian

or do not each much red meat then this may also cause a reduction in

creatine and creatinine levels. 2. Creatine can be synthesized in the

liver from guanidinoacetic acid. This enzyme reaction also uses S-

adenosylmethionine (SAMe). Liver disease could impair this reaction

by reducing the amount of the enzyme or the amount of available SAMe.

[A sign of a deficiency of SAMe might be elevated serum homocysteine.

Elevated homocysteine could in turn be caused by folate deficiency,

or vitamin B deficiency, or deficiency of glycine betaine .... but

that's another story].

A 100 page review of the creatine and creatinine metabolism can be

found here:

Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism.

Physiol. Rev. 80: 1107-1213.

http://physrev.physiology.org/cgi/content/full/80/3/1107

One web article indicates:

" Causes of low creatinine include small stature, debilitation,

decreased muscle mass, some complex cases of severe hepatic disease.

In advanced liver disease, low creatinine may result from decreased

hepatic production of creatinine and inadequate dietary protein as

well as reduced muscle mass. "

http://www.labcorp.com/datasets/labcorp/html/chapter/mono/pr003900.htm

If you are concerned about the low creatinine, please do talk to your

doctor about possible causes and whether it is of any significance.

Best regards,

Dave

(father of (22); PSC 07/03; UC 08/03)

> In my bloodtests usually creatinine comes out a little below the

lowe border. As I understand they are testing creatinine to see if

the level isn't elevated as would happen in a kidney disfunction.

Still, I was wondering if a low creatinine level in the blood

(haven't tested the urine) is associated with something (maybe even

PSC itself?)?

[Guest guest]

Hi Gerard;

Creatinine is derived from creatine, which is an important component

of muscle. If you are of small stature and have lower than normal

muscle mass (like me!), then your creatine level may be on the low

end of the normal scale, and so your serum creatinine may also be on

the low end of the normal scale. Serum creatinine seems to follow

serum creatine level.

Creatine comes from two sources (in addition to turnover of your own

muscle tissue). 1. Diet (e.g. ingested meat). If you are a vegetarian

or do not each much red meat then this may also cause a reduction in

creatine and creatinine levels. 2. Creatine can be synthesized in the

liver from guanidinoacetic acid. This enzyme reaction also uses S-

adenosylmethionine (SAMe). Liver disease could impair this reaction

by reducing the amount of the enzyme or the amount of available SAMe.

[A sign of a deficiency of SAMe might be elevated serum homocysteine.

Elevated homocysteine could in turn be caused by folate deficiency,

or vitamin B deficiency, or deficiency of glycine betaine .... but

that's another story].

A 100 page review of the creatine and creatinine metabolism can be

found here:

Wyss M, Kaddurah-Daouk R (2000) Creatine and creatinine metabolism.

Physiol. Rev. 80: 1107-1213.

http://physrev.physiology.org/cgi/content/full/80/3/1107

One web article indicates:

" Causes of low creatinine include small stature, debilitation,

decreased muscle mass, some complex cases of severe hepatic disease.

In advanced liver disease, low creatinine may result from decreased

hepatic production of creatinine and inadequate dietary protein as

well as reduced muscle mass. "

http://www.labcorp.com/datasets/labcorp/html/chapter/mono/pr003900.htm

If you are concerned about the low creatinine, please do talk to your

doctor about possible causes and whether it is of any significance.

Best regards,

Dave

(father of (22); PSC 07/03; UC 08/03)

> In my bloodtests usually creatinine comes out a little below the

lowe border. As I understand they are testing creatinine to see if

the level isn't elevated as would happen in a kidney disfunction.

Still, I was wondering if a low creatinine level in the blood

(haven't tested the urine) is associated with something (maybe even

PSC itself?)?

[Guest guest]

Dear Dave,

Thank you again so much for all the information that you provide us

with. You are invaluable.

Gerard

[Guest guest]

Dear Dave,

Thank you again so much for all the information that you provide us

with. You are invaluable.

Gerard

[Guest guest]

Dear Dave,

Thank you again so much for all the information that you provide us

with. You are invaluable.

Gerard