Re: Prilosec

[Guest guest]

Hi Rick;

Yes, there have been a few reports that prilosec (omeprazole) may help

alleviate symptoms of inflammatory bowel disease in some patients, see

for example:

J Clin Gastroenterol. 1994 Jun;18(4):317-9.

Is omeprazole helpful in inflammatory bowel disease?

Dickinson JB

Department of Medicine, Veterans Memorial Medical Center, Meriden,

Connecticut.

Omeprazole, a proton pump inhibitor, was added to the treatment regimen

of seven patients with biopsy proven inflammatory bowel disease. Six of

the seven patients showed a marked clinical improvement in symptoms,

especially pain and diarrhea after starting omeprazole. One of the six

is using omeprazole as her sole medication for her colitis currently.

Others have been able to decrease steroid doses. A possible mechanism

of action relates the similar chemical structure of omeprazole to

metronidazole which is efficacious in colitis. PMID: 8071518.

Glad to hear that it's helpful for you!

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

> several months ago I started taking a generic of Prilosec because of

acid reflux. I have not had a loose stool since then. Has there been

any studies done to show whether this disease helps UC?

[Guest guest]

Would nexium also be considered the same as Prilosec for the control of UC?

Shirley,

Mom of Tyler, tx 2-07, UC 8-07

[Guest guest]

Hi Shirley;

Nexium is closely related to Prilosec. As described in this

article ... " Nexium is derived from Prilosec (omeprazole). Prilosec

contains a racemic mixture of the D- and L- forms (isomers) of

omeprazole. Nexium contains only one of the isomers. Both Prilosec

and Nexium are known as proton pump inhibitors. "

http://www.centerwatch.com/patient/drugs/dru665.html

But as far as I know, only Prilosec has been studied for effects on

ulcerative colitis. The article I posted a few days ago:

Dickinson JB (1994) Is omeprazole helpful in inflammatory bowel

disease? J. Clin. Gastroenterol. 18: 317-319.

http://www.ncbi.nlm.nih.gov/pubmed/8071518

only looked at Prilosec, not at Nexium. But it is reasonable to

suppose that Nexium might have similar effects.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

>

> Would nexium also be considered the same as Prilosec for the

control of UC?

[Guest guest]

,

I've been prescribed Nexium for reflux, to try and counteract a cough I have

at night. When I lie down, I cough like crazy (all night long), and after

all the asthma tests have been done, the lung dr said try this. It

apparently takes a while to work, so I'm not seeing absolute results yet,

but I think it is improving. How does this correlate to UC, what, in laymans

terms are proton pump inhibitors "

Thanks,

Penny T (Australia)

Hi Shirley;

Nexium is closely related to Prilosec. As described in this

article ... " Nexium is derived from Prilosec (omeprazole). Prilosec

contains a racemic mixture of the D- and L- forms (isomers) of

omeprazole. Nexium contains only one of the isomers. Both Prilosec

and Nexium are known as proton pump inhibitors. "

[Guest guest]

Hi Penny;

I'm not sure whether this will be understandable to a layperson, but

here's the description of proton-pump inhibitors in Wikipedia:

http://en.wikipedia.org/wiki/Proton_pump_inhibitor

Proton-pump inhibitors basically block the excretion of protons

(which contribute to acidity) in the stomach. Thus they suppress

gastric acid production in the stomach. I'm not sure that it has

anything to do with UC directly.

The original question about Prilosec was that someone was prescribed

it for gastrointestinal reflux disease (GERD) (gastric acid reflux

into the esophagus) and it seemed to also help their UC .... was

there any evidence to support this in the literature? .... answer ...

yes, just a little, but it is not clear exactly why!

Anyway, to come to your question about why your doctor asked you to

try Prilosec for your nightime cough, it's possible that he may

suspect laryngopharyngeal reflux disease, which is mentioned in the

Wikipedia article as one of the conditions that is treated by proton-

pump inhibitors.

http://en.wikipedia.org/wiki/Laryngopharyngeal_Reflux_Disease

" Laryngopharyngeal reflux is the retrograde movement of the acidic

contents of the stomach up the oesophagus to the larynx where it

causes such symptoms as hoarseness, postnasal drip, sore throat,

difficulty swallowing and chronic coughing and throat clearing. Other

side-effects include a bitter taste in the mouth, especially in the

morning, asthma, earache and difficulty singing high notes. "

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

> I've been prescribed Nexium for reflux, to try and counteract a

cough I have at night. When I lie down, I cough like crazy (all night

long), and after all the asthma tests have been done, the lung dr

said try this. It apparently takes a while to work, so I'm not seeing

absolute results yet, but I think it is improving. How does this

correlate to UC, what, in laymans terms are proton pump inhibitors