Re: High Iron/lipoic acid

[Guest guest]

> you might want to research the supplement - alpha lipoic acid to

help remove metals from the blood.

I'd be very cautious about taking lipoic acid supplements without

your hepatologist's consent, and even with his/her consent ...

lipoic acid is implicated as a potential cause of primary biliary

cirrhosis (PBC), and we don't know if something similar could occur

in PSC:

Gastroenterology. 2003 Dec;125(6):1705-13.

Autoreactivity to lipoate and a conjugated form of lipoate in primary

biliary cirrhosis.

Bruggraber SF, Leung PS, Amano K, Quan C, Kurth MJ, Nantz MH, Benson

GD, Van de Water J, Luketic V, Roche TE, Ansari AA, Coppel RL,

Gershwin ME

Division of Rheumatology, Allergy and Clinical Immunology, University

of California at Medical School, 95616, USA.

BACKGROUND & AIMS: Although considerable effort has been directed

toward the mapping of peptide epitopes by autoantibodies, the role of

nonprotein molecules has been less well studied. The immunodominant

autoantigen in primary biliary cirrhosis (PBC), E2 components of

pyruvate dehydrogenase complexes (PDC-E2), has a lipoate molecule

bonded to the domain to which autoantibodies are directed. METHODS:

We examined sera from patients with PBC (n = 105), primary sclerosing

cholangitis (n = 70), and rheumatoid arthritis (n = 28) as well as

healthy volunteers (n = 43) for reactivity against lipoic acid. The

lipoic acid hapten specificity of the reactive antibodies in PBC sera

was determined following incubation of aliquots of the sera with

human serum albumin (HSA), lipoylated HSA (HSA-LA), PDC-E2,

lipoylated PDC-E2, polyethylene glycol (PEG), lipoylated PEG, free

lipoic acid, and synthetic molecular mimics of lipoic acid. RESULTS:

Anti-lipoic acid specific antibodies were detected in 81% (79 of 97)

of antimitochondrial antibody (AMA)-positive patients with PBC but

not in controls. Two previously unreported specificities in AMA-

positive sera that recognize free lipoic acid and a carrier-

conjugated form of lipoic acid were also identified. CONCLUSIONS: We

hypothesize that conjugated form(s) of native or xenobiotic lipoic

acid mimics contribute to the initiation and perpetuation of

autoimmunity by at first breaking self-tolerance and participating in

subsequent determinant spreading. The variability in the

immunoreactive carrier/lipoate conjugates provides an experimental

framework on which potential mechanisms for the breakdown of self-

tolerance following exposure to xenobiotics can be investigated. The

data have implications for patients taking lipoic acid as a dietary

supplement. PMID: 14724823.

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

[Guest guest]

that's an interesting read - back when mike was struggling with the disease a renowned naturopath gave us a book to read by a researcher at Berkeley University and he used Alpha Lipoic Acid to treat liver disease, perhaps they've found out some new digs on it, but mike took it, my brother took it with success as he had high iron in his blood -

I guess things like this have to be re-visited.....

Patti'tough times don't last - tough people do'> To: > Date: Sun, 27 Jul 2008 22:17:55 +0000> Subject: Re: High Iron/lipoic acid> > > > > you might want to research the supplement - alpha lipoic acid to > help remove metals from the blood.> > > I'd be very cautious about taking lipoic acid supplements without > your hepatologist's consent, and even with his/her consent ... > lipoic acid is implicated as a potential cause of primary biliary > cirrhosis (PBC), and we don't know if something similar could occur > in PSC:> > Gastroenterology. 2003 Dec;125(6):1705-13.> > Autoreactivity to lipoate and a conjugated form of lipoate in primary > biliary cirrhosis.> > Bruggraber SF, Leung PS, Amano K, Quan C, Kurth MJ, Nantz MH, Benson > GD, Van de Water J, Luketic V, Roche TE, Ansari AA, Coppel RL, > Gershwin ME> > Division of Rheumatology, Allergy and Clinical Immunology, University > of California at Medical School, 95616, USA.> > BACKGROUND & AIMS: Although considerable effort has been directed > toward the mapping of peptide epitopes by autoantibodies, the role of > nonprotein molecules has been less well studied. The immunodominant > autoantigen in primary biliary cirrhosis (PBC), E2 components of > pyruvate dehydrogenase complexes (PDC-E2), has a lipoate molecule > bonded to the domain to which autoantibodies are directed. METHODS: > We examined sera from patients with PBC (n = 105), primary sclerosing > cholangitis (n = 70), and rheumatoid arthritis (n = 28) as well as > healthy volunteers (n = 43) for reactivity against lipoic acid. The > lipoic acid hapten specificity of the reactive antibodies in PBC sera > was determined following incubation of aliquots of the sera with > human serum albumin (HSA), lipoylated HSA (HSA-LA), PDC-E2, > lipoylated PDC-E2, polyethylene glycol (PEG), lipoylated PEG, free > lipoic acid, and synthetic molecular mimics of lipoic acid. RESULTS: > Anti-lipoic acid specific antibodies were detected in 81% (79 of 97) > of antimitochondrial antibody (AMA)-positive patients with PBC but > not in controls. Two previously unreported specificities in AMA-> positive sera that recognize free lipoic acid and a carrier-> conjugated form of lipoic acid were also identified. CONCLUSIONS: We > hypothesize that conjugated form(s) of native or xenobiotic lipoic > acid mimics contribute to the initiation and perpetuation of > autoimmunity by at first breaking self-tolerance and participating in > subsequent determinant spreading. The variability in the > immunoreactive carrier/lipoate conjugates provides an experimental > framework on which potential mechanisms for the breakdown of self-> tolerance following exposure to xenobiotics can be investigated. The > data have implications for patients taking lipoic acid as a dietary > supplement. PMID: 14724823.> > Best regards,> > Dave > (father of (23); PSC 07/03; UC 08/03)> > > > > ------------------------------------> >