Can medication cause PSC type damage to the liver?

[Guest guest]

Just curious if some of the drugs I've taken for crohn's disease may

have had an effect of the billary system of my liver. I've searched

the internet with few results.

TIA

C.

[Guest guest]

Not that I've heard, but that doesn't mean much. Try " drug-induced biliary

damage " as a search term. The only med that MAY be implicated (using these

search terms) is Amoxicillin - Clavulanic Acid. See

http://pearl.sums.ac.ir/semj/vol2/jul2001/liver&coamoxy.htm and

http://justiceforej.com/Al-BayatiReport.pdf

I wouldn't think this drug would normally be used with Crohn's. Also, affected

individuals appear to imply a genetic predisposition.

Arne

---- fcbostonrocks CloudR11rt@...> wrote:

=============

Just curious if some of the drugs I've taken for crohn's disease may

have had an effect of the billary system of my liver. I've searched

the internet with few results.

TIA

C.

[Guest guest]

So there is a potential there, that a child, like , who was sick from birth - pneumonias, ear infections, more pneumonias, and was on amox quite a bit (with zithro thrown in to try to avoid resistance) could have "possibly" had his damage caused by the antibiotics?

Ami - Migraines, FMS

mom to - 10 yrs - Double Lung Tx 2/26/2006, PSC - Tx 7/16/2007, Diabetes, Hypothyroid, GERD, ADHD, Osteopenia http://caringbridge.org/visit/seanfox

mom to Emma - 14 yrs - Migraines

stepmom to - 15 yrs - ADHD, ODD

~~~~~~~~~~~~ ~~~~~~~~~ ~~~~~~~~~ ~~~~~~~~~ ~~~~~ ============ =Just curious if some of the drugs I've taken for crohn's disease may have had an effect of the billary system of my liver. I've searched

the internet with few results.TIA C.

[Guest guest]

So there is a potential there, that a child, like , who was sick from birth - pneumonias, ear infections, more pneumonias, and was on amox quite a bit (with zithro thrown in to try to avoid resistance) could have "possibly" had his damage caused by the antibiotics?

Ami - Migraines, FMS

mom to - 10 yrs - Double Lung Tx 2/26/2006, PSC - Tx 7/16/2007, Diabetes, Hypothyroid, GERD, ADHD, Osteopenia http://caringbridge.org/visit/seanfox

mom to Emma - 14 yrs - Migraines

stepmom to - 15 yrs - ADHD, ODD

~~~~~~~~~~~~ ~~~~~~~~~ ~~~~~~~~~ ~~~~~~~~~ ~~~~~ ============ =Just curious if some of the drugs I've taken for crohn's disease may have had an effect of the billary system of my liver. I've searched

the internet with few results.TIA C.

[Guest guest]

Not based on what I read. It has to be the Amoxicillin - Clavulanic Acid

combination, not Amoxicillin by itself.

Arne

---- Ami Fox amifox73@...> wrote:

=============

So there is a potential there, that a child, like , who was sick from birth

- pneumonias, ear infections, more pneumonias, and was on amox quite a bit (with

zithro thrown in to try to avoid resistance) could have " possibly " had his

damage caused by the antibiotics?

[Guest guest]

Not based on what I read. It has to be the Amoxicillin - Clavulanic Acid

combination, not Amoxicillin by itself.

Arne

---- Ami Fox amifox73@...> wrote:

=============

So there is a potential there, that a child, like , who was sick from birth

- pneumonias, ear infections, more pneumonias, and was on amox quite a bit (with

zithro thrown in to try to avoid resistance) could have " possibly " had his

damage caused by the antibiotics?

[Guest guest]

Not based on what I read. It has to be the Amoxicillin - Clavulanic Acid

combination, not Amoxicillin by itself.

Arne

---- Ami Fox amifox73@...> wrote:

=============

So there is a potential there, that a child, like , who was sick from birth

- pneumonias, ear infections, more pneumonias, and was on amox quite a bit (with

zithro thrown in to try to avoid resistance) could have " possibly " had his

damage caused by the antibiotics?

[Guest guest]

Amoxixillin - Clavulanic is Augmentin and here is what is listed on

RXlist.com about it's hepatic side effects.

Liver: A moderate rise in AST (SGOT) and/or ALT (SGPT) has been

noted in patients treated with ampicillin-class antibiotics, but the

significance of these findings is unknown. Hepatic dysfunction,

including increases in serum transaminases (AST and/or ALT), serum

bilirubin and/or alkaline phosphatase, has been infrequently

reported with amoxicillin/clavulanate potassium. It has been

reported more commonly in the elderly, in males, or in patients on

prolonged treatment. The histologic findings on liver biopsy have

consisted of predominantly cholestatic, hepatocellular, or mixed

cholestatic-hepatocellular changes. The onset of signs/symptoms of

hepatic dysfunction may occur during or several weeks after therapy

has been discontinued. The hepatic dysfunction, which may be severe,

is usually reversible. On rare occasions, deaths have been reported

(less than 1 death reported per estimated 4 million prescriptions

worldwide). These have generally been cases associated with serious

underlying diseases or concomitant medications.

http://www.rxlist.com/cgi/generic/amoxclav_ad.htm

I have been on very large doses of this medication for prolonged

periods due to ear infections when I was younger. I think I will

need to ask my doctor about this.

Dawn

In , wrote:

>

> Not based on what I read. It has to be the Amoxicillin -

Clavulanic Acid combination, not Amoxicillin by itself.

>

>

> Arne

>

[Guest guest]

Amoxixillin - Clavulanic is Augmentin and here is what is listed on

RXlist.com about it's hepatic side effects.

Liver: A moderate rise in AST (SGOT) and/or ALT (SGPT) has been

noted in patients treated with ampicillin-class antibiotics, but the

significance of these findings is unknown. Hepatic dysfunction,

including increases in serum transaminases (AST and/or ALT), serum

bilirubin and/or alkaline phosphatase, has been infrequently

reported with amoxicillin/clavulanate potassium. It has been

reported more commonly in the elderly, in males, or in patients on

prolonged treatment. The histologic findings on liver biopsy have

consisted of predominantly cholestatic, hepatocellular, or mixed

cholestatic-hepatocellular changes. The onset of signs/symptoms of

hepatic dysfunction may occur during or several weeks after therapy

has been discontinued. The hepatic dysfunction, which may be severe,

is usually reversible. On rare occasions, deaths have been reported

(less than 1 death reported per estimated 4 million prescriptions

worldwide). These have generally been cases associated with serious

underlying diseases or concomitant medications.

http://www.rxlist.com/cgi/generic/amoxclav_ad.htm

I have been on very large doses of this medication for prolonged

periods due to ear infections when I was younger. I think I will

need to ask my doctor about this.

Dawn

In , wrote:

>

> Not based on what I read. It has to be the Amoxicillin -

Clavulanic Acid combination, not Amoxicillin by itself.

>

>

> Arne

>

[Guest guest]

Amoxixillin - Clavulanic is Augmentin and here is what is listed on

RXlist.com about it's hepatic side effects.

Liver: A moderate rise in AST (SGOT) and/or ALT (SGPT) has been

noted in patients treated with ampicillin-class antibiotics, but the

significance of these findings is unknown. Hepatic dysfunction,

including increases in serum transaminases (AST and/or ALT), serum

bilirubin and/or alkaline phosphatase, has been infrequently

reported with amoxicillin/clavulanate potassium. It has been

reported more commonly in the elderly, in males, or in patients on

prolonged treatment. The histologic findings on liver biopsy have

consisted of predominantly cholestatic, hepatocellular, or mixed

cholestatic-hepatocellular changes. The onset of signs/symptoms of

hepatic dysfunction may occur during or several weeks after therapy

has been discontinued. The hepatic dysfunction, which may be severe,

is usually reversible. On rare occasions, deaths have been reported

(less than 1 death reported per estimated 4 million prescriptions

worldwide). These have generally been cases associated with serious

underlying diseases or concomitant medications.

http://www.rxlist.com/cgi/generic/amoxclav_ad.htm

I have been on very large doses of this medication for prolonged

periods due to ear infections when I was younger. I think I will

need to ask my doctor about this.

Dawn

In , wrote:

>

> Not based on what I read. It has to be the Amoxicillin -

Clavulanic Acid combination, not Amoxicillin by itself.

>

>

> Arne

>