Dave- immunodeficiency question, random thoughts

[Guest guest]

Hi Dave

You have been such a great resource to everyone here, myself included

and I really appreciate your input on this. The recent question @ IgA

deficiency has me wondering if there is much research out there about

immunodeficencies and PSC. My son Braden has low IgG and IgM and has

not retained immunity to all but one (and minimal on the one-barely in

normal range) of the immunizations they have tested in his immune

function tests. His IgA and IgE are ok.

He was getting monthly IVIG infusions, until our insurance randomly

decided not to pay some of the cost- but did for most months ?!?! so

we finally (crossed fingers) have that straightened out and will start

again soon hopefully...

Hyper IgM is an autoimmune indicator right ? Because IgM fights

bacterial infections ?

I think in my son's case the low IgG is caused by his very poor gut

functioning- most his small bowel has been removed and he has had

chronic and severe small bowel bacterial overgrowth problems that I

feel were there the triggers for his PSC. He does not have autoimmune

problems so maybe his PSC is 'just' SC ?? I am still not clear on why

the 'P' is added to make it a primary and why it is considered

secondary if there is a known source isn't the autoimmune disease the

known source so shouldn't it be called auto-immune sclerosing

cholangitis then ? This is just my take on things that it is called

secondary when there is a known source and that assumes you can

control the known source- not the case with my son though that we can

control the source...

I guess I am just confused on what the immune connection is and how it

relates to my son and if it is different for him than others with

auto- immune disease. Any thought appreciated -even if you just want

to tell me I am rambling and not making sense :-)

Lori

lucky mom blessed with triplets