Re: Urso/DHA question

[Guest guest]

Hi Nina;

The serum alkaline phosphatase (ALP) level can increase 30 units in

healthy people simply due to food ingestion. Therefore ALP level

could change by 25 or more units depending upon time after last meal

that the blood sample was taken.

see Table 4 of

Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB 2000

Diagnosis and monitoring of hepatic injury. I. Performance

characteristics of laboratory tests. Clin. Chem. 46: 2027-2049.

http://www.clinchem.org/cgi/reprint/46/12/2027

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

[Guest guest]

Hi Nina;

The serum alkaline phosphatase (ALP) level can increase 30 units in

healthy people simply due to food ingestion. Therefore ALP level

could change by 25 or more units depending upon time after last meal

that the blood sample was taken.

see Table 4 of

Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB 2000

Diagnosis and monitoring of hepatic injury. I. Performance

characteristics of laboratory tests. Clin. Chem. 46: 2027-2049.

http://www.clinchem.org/cgi/reprint/46/12/2027

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

[Guest guest]

Hi Nina;

The serum alkaline phosphatase (ALP) level can increase 30 units in

healthy people simply due to food ingestion. Therefore ALP level

could change by 25 or more units depending upon time after last meal

that the blood sample was taken.

see Table 4 of

Dufour DR, Lott JA, Nolte FS, Gretch DR, Koff RS, Seeff LB 2000

Diagnosis and monitoring of hepatic injury. I. Performance

characteristics of laboratory tests. Clin. Chem. 46: 2027-2049.

http://www.clinchem.org/cgi/reprint/46/12/2027

Best regards,

Dave

(father of (23); PSC 07/03; UC 08/03)

[Guest guest]

Nina,

In theory every one needs a dose that is specific to them. Some in this group don't tolerate URSO well but others do. I'm on a couple of other medications (one for thyroid and a blood thinner) which they adjust my dosage based on blood test results.

Ian (52) PSC 89

Hi, all. Quick question for the chemistry-minded of you. My husband has been on high-dose Urso and DHA since ~late spring '06 and, over the course of many months, his Alk Phos finally dropped into the top

of the normal range. It stayed right there, at the very top of normal, for ages. It was really consistent - like no more than 1 or 2 points change up/down every 3 months. This summer, with the Mayo high-dose Urso study called off, we reduced his dose of Urso slightly,

although it is still on the high end. Yesterday, when he got his blood tests back, his Alk Phos had dipped, for the first time, lower into the normal range - it was a good 25-point dip. This makes me wonder whether there is any possibility that some ratio of DHA:Urso is

really the ideal combination? Is there any possible biochemical basis for this? Thanks,Nina in Philly -- Ian Cribb P.Eng.