paper in the journal Toxicology

[Guest guest]

For those who haven't seen this yet, it is a must-read!

The role of thiols, dithiols, nutritional factors and

interacting ligands in the toxicology of mercury.

J.P.K. Rooney, Toxicology 2007 Mar 1.

A copy of the paper is available in the autism-mercury files

(search for Rooney):

http://health.groups.yahoo.com/group/Autism-Mercury/files/

A few teasers:

" Further research is needed into the actions of ALA as a chelator -

in particular investigation of frequent low dose chelation as

suggested by Cutler (1999). ...Cutler makes a plausible argument

regarding the frequency of chelator dosing which merits the attention

of the scientific community. ...it is also clear...that the effect

of ALA on mercury toxicity is dependent on dosage size and on the

spacing of dosages in time. "

" ...NAC and GSH would appear to be poor treatment choices for mercury

toxicity due to the high risk for redistribution of mercury... "

" ...chelation challenge tests...do not accurately reflect mercury

levels in the brain. Given that the brain is one of the main target

organs for both elemental and organic mercury, and that the brain

retains mercury for many years...this is a fairly serious flaw. "

" Current chelation challenge tests are inaccurate as used clinically,

and owing to the large doses often used, carry risks to the patient

of redistribution of mercury... "