Erectile Dysfunction in Liver Transplant Patients

[Guest guest]

http://www3.interscience.wiley.com/journal/121430357/abstract?CRETRY=1 & SRETRY=0

Erectile Dysfunction in Liver Transplant Patients

E. Huyghe a,d,*, N. Kamar b,e , F. Wagner d , S. J. Yeung d , A. H. Capietto d , L. El-Kahwaji b , F. Muscari c , P. Plante a,d and L. Rostaing b,f

a Department of Urology and Andrology , b Nephrology, Dialysis, and Multiorgan Transplant Unit , c Digestive Surgery Department, University Hospital, CHU Rangueil, Toulouse, France d EA 3694, Sabatier University, CHU e de Viguier, Toulouse, France e INSERM U858, IFR 31, Toulouse, France f INSERM U563, IFR 30, Toulouse, France

* Corresponding author: Huyghe, huyghe.e@...

Copyright © 2008 American Society of Transplantation and the American Society of Transplant Surgeons

KEYWORDS

End-stage liver disease • erectile dysfunction • liver transplantation • questionnaire • sexual activity

ABSTRACT

The objectives of the study were to determine the frequency of erectile dysfunction (ED) after liver transplantation (LT) and discuss potential risk factors. Of 123 eligible LT men, 98 (79.7%) responded to a questionnaire about sexual function at a mean time posttransplant of 5.4 ± 4.0 years (1.0–21). Erection was evaluated using the five-question international index for erectile function score, and sexual satisfaction by the patient-baseline treatment-satisfaction status (TSS) score. Questions also focused on patient perception of changes overtime. We found that after LT, the proportion of sexually inactive men decreased from 29% to 15% (p = 0.01), but the proportion of men with ED remained unchanged. The absence of sexual activity was associated with pretransplant sexual inactivity (p = 0.001), age (p = 0.008), cardiovascular disease (p = 0.03), use of diuretics (p = 0.04), anticoagulants (p = 0.001), statins (p = 0.01) and treatment for diabetes (p = 0.03). Cardiovascular disease (p = 0.05), posttransplantation diabetes (p = 0.04), alcohol abuse (p = 0.03), antidepressants (p = 0.05) and angiotensin II receptor blockers (p = 0.05) were associated with having ED after LT. Having a low TSS score was associated with a history of endocrine disease (p = 0.03), antidepressants (p = 0.04) and diuretics (p = 0.03).

In conclusion, LT improves sexual activity, but ED is multifactorial and remains a long-term condition in the majority of patients.

Received 28 April 2008, revised 06 August 2008 and accepted for publication 18 August 2008

DIGITAL OBJECT IDENTIFIER (DOI)10.1111/j.1600-6143.2008.02424.x About DOI