Re: Increased Risk of PSC & UC in 1st degree family

[Guest guest]

and Chaim, I think about this issue a lot, both as a parent and

as a daughter. It makes me sick to my stomach as well to think of my

kids getting either PSC or UC. And I know that mom has guilt about

having passed on some defective genes, because all three of us kids

have serious chronic ailments. It's a terrible feeling of unease.

I try to stay optimistic with the fact that genetics are a only a

predisposition, and the chances really are low. Though I carry the

unease around with me.

Ruth

UC - 2000, Colectomy - 2007, PSC - 2008

Mother of Tamar (3) and Erez (9 months)

> If I understand this right there is an 11.5 fold chance that first

degree

> family members get IBD. The chance according to the CCFA (IBD

association)

> is 149 per 100.000. An 11.5 fold increase makes the probability 1.7%.

This

> is high, but there is still a 98.3% chance your kids will not get it.

I like

> those odds.

>

> Regards,

>

> Chaim Boermeester, Israel

>

[Guest guest]

and Chaim, I think about this issue a lot, both as a parent and

as a daughter. It makes me sick to my stomach as well to think of my

kids getting either PSC or UC. And I know that mom has guilt about

having passed on some defective genes, because all three of us kids

have serious chronic ailments. It's a terrible feeling of unease.

I try to stay optimistic with the fact that genetics are a only a

predisposition, and the chances really are low. Though I carry the

unease around with me.

Ruth

UC - 2000, Colectomy - 2007, PSC - 2008

Mother of Tamar (3) and Erez (9 months)

> If I understand this right there is an 11.5 fold chance that first

degree

> family members get IBD. The chance according to the CCFA (IBD

association)

> is 149 per 100.000. An 11.5 fold increase makes the probability 1.7%.

This

> is high, but there is still a 98.3% chance your kids will not get it.

I like

> those odds.

>

> Regards,

>

> Chaim Boermeester, Israel

>

[Guest guest]

I agree too Arne, I'm sure happy I was born and I do hope the

circumstances will allow me to have at least one more child. I still

feel this dread though about these vulnerable little human beings who I

love so much having to go through what I've been through... But I have

to say there is positive in the experience - there has been incredible

growth and connectness and appreciation of life and loved ones that has

resulted from my diagnosis.

Ruth

I'm very glad I was born (and so is my wife, usually:). Do I wish my

parents had made a different decision? ABSOLUTELY NOT.

[Guest guest]

I agree too Arne, I'm sure happy I was born and I do hope the

circumstances will allow me to have at least one more child. I still

feel this dread though about these vulnerable little human beings who I

love so much having to go through what I've been through... But I have

to say there is positive in the experience - there has been incredible

growth and connectness and appreciation of life and loved ones that has

resulted from my diagnosis.

Ruth

I'm very glad I was born (and so is my wife, usually:). Do I wish my

parents had made a different decision? ABSOLUTELY NOT.

[Guest guest]

I agree too Arne, I'm sure happy I was born and I do hope the

circumstances will allow me to have at least one more child. I still

feel this dread though about these vulnerable little human beings who I

love so much having to go through what I've been through... But I have

to say there is positive in the experience - there has been incredible

growth and connectness and appreciation of life and loved ones that has

resulted from my diagnosis.

Ruth

I'm very glad I was born (and so is my wife, usually:). Do I wish my

parents had made a different decision? ABSOLUTELY NOT.

[Guest guest]

After reading these posts my Dad who is 85, who knows lots of both my

Mother's and his families history, sat down with the family trees on

both sides of my family for 4 generations, (Mum and Dad's parents,

his generation, my generation and my children's generation) there

appears to be no family history of IBD or PSC that we know of on

either side, expect for my older sister and younger brother having UC

and me with PSC and my youngest son (aged 27) has proctitis. So

there may be a genetic component from my Dad and Mum combination! So

thats the odds!

Best wishes

--- In , Chaim Boermeester

> If I understand this right there is an 11.5 fold chance that first

degree

> family members get IBD. The chance according to the CCFA (IBD

association)

> is 149 per 100.000. An 11.5 fold increase makes the probability

1.7%. This

> is high, but there is still a 98.3% chance your kids will not get

it. I like

> those odds.

> Regards,

> Chaim Boermeester, Israel