Guest guest Posted June 3, 2010 Report Share Posted June 3, 2010 That was all very interesting, TY Elenor. For me, I'm just a bit afraid of getting Barrets b/c I have stage 2 esophagitis. I have been taking Protonix now since last September. I stop it once in a while and wait and see if I get heartburn, if I do, I start taking it again. I believe in the theory of needing acid in the stomach, but if one already has a condition, such as mine, it's too scary to me to stop my PPI and use HCL. I am using a digestive enzyme product w/o HCL. Are those enzymes acidic? I have not asked my gastro MD as he told me to stop all vitamins, iron included while on this medication. I didn't b/c I had low ferritin and I don't eat as well as I should, so I take multis, calcium for my osteopenia too. I'm very afraid of getting Barrets from my esophagitis. I also have dudonitis and hiatus hernia to boot. > > Permit me to recommend to you (y'all) a couple of blog entries with some good info about stomach acid, reflux, and all that. > > http://www.proteinpower.com/drmike/uncategorized/heartburn-cured/ (how it all works, when it works right, and what can lead to it not working) > > http://www.proteinpower.com/drmike/uncategorized/corn-eating-cow-crap-chuckin-up\ -your-insides-blues/ > > http://www.proteinpower.com/drmike/supplements/protexid-and-protexid-nd-and-adve\ ntures-in-dr/ (This offer of his has expired, I expect -- but the info is still sound.) > > About: proton pump inhibiting drugs: http://www.proteinpower.com/drmike/good-eating/another-reason-to-eat-grass-fed-b\ eef/ > > I've been reading Dr Eades for nearly a decade: I trust him. I have found him to be honest, honorable, extremely deep-thinking. He has spent a chunk of his blog dissecting and revealing how medical studies are badly done, or badly reported: he actually reads the medical studies, not just the conclusions -- or worse, the media reports of the conclusions -- and as was recently posted in the Diabetes Update (http://diabetesupdate.blogspot.com/2010/05/what-health-media-missed-jama-study.\ html) blog: > =================== > ... Almost always close reading of these studies finds statistical abuse so blatant that one concludes that the peer reviewers who approved it for publication flunked Statistics 101. > > Now a study in JAMA quantifies just how bad this statistical abuse really is. The study is, > > Reporting and Interpretation of Randomized Controlled Trials With Statistically Nonsignificant Results for Primary Outcomes. Isabelle Boutron et al. JAMA 2010;303(20):2058-2064. > > ... > What the JAMA study found was that in 72 studies where the primary outcome resulted in a statistically nonsignificant result there was significant " spin. " > > Spin was defined thus: > > ...specific reporting strategies, whatever their motive, to highlight that the experimental treatment is beneficial, despite a statistically nonsignificant difference for the primary outcome, or to distract the reader from statistically nonsignificant results > > > > In plain English, " spin " means claiming some treatment works when the statistics show it does not. > > How frequent was spin? The JAMA Study finds: > > The title was reported with spin in 13 articles (18.0%) > > Spin was identified in the Results and Conclusions sections of the abstracts of 27 (37.5%) and 42 (58.3%) reports, respectively, with the conclusions of 17 (23.6%) focusing only on treatment effectiveness. > > Spin was identified in the main-text Results, Discussion, and Conclusions sections of 21 (29.2%), 31 (43.1%), and 36 (50.0%) reports, respectively. > > More than 40% of the reports had spin in at least 2 of these sections in the main text. > > So no, I am not paranoid when I assert that peer reviewers approve the publication of studies that claim results where none occurred, based on ignorance of how statistics work. > ... > =================== > Hope you find the info helpful, > Elenor > Quote Link to comment Share on other sites More sharing options...
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