Re: Re: A new piece of the PSC puzzle discovered

[Guest guest]

, thanks for your response! How do we consume the Cholic Acid or Bile Acid or is it just in our system already? How can we prevent this Cholic Acid that converts into deoxycholic acid?

Lori A.

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Re: A new piece of the PSC puzzle discovered

Hi Lori;Cholic acid is a bile acid that can become toxic to the liver because it gets converted to deoxycholic acid. The deoxycholic acid can cause cell damage not only in the liver, but also in the colon, and may contribute to development of colon cancer.The mouse model has been used to show that ursodeoxycholic acid (UCDA, Actigall) protects against colon cancer caused by cholic acid feeding:Int. J. Cancer 2006 Jun 1;118(11):2750- 7. Prevention of colitis-associated carcinogenesis in a mouse model by diet supplementation with ursodeoxycholic acid.Loddenkemper C, Keller S, Hanski ML, Cao M, Jahreis G, Stein H, Zeitz M, Hanski CInstitut für Pathologie, Charité Campus lin, Berlin, Germany.Bile acids in the intestinal lumen contribute to the homeostatic regulation of proliferation and death of the colonic epithelial cells: Deoxycholic acid

(DCA) appears to enhance and ursodeoxycholic acid (UDCA) to attenuate the process of chemically induced carcinogenesis. We studied the effects of UDCA on colitis-related colorectal carcinogenesis. Three groups of 25 mice were given 0.7% dextran sulphate in drinking water for 7 days and pure water for 10 days and were fed a standard diet containing double iron concentration. In 2 groups, the diet was supplemented with 0.2% cholic acid (CA), the precursor of DCA, or with 0.4% UDCA. After 15 cycles, the histology, the expression of MUC2, beta-catenin, p27 and p16 and the fecal water concentration of DCA and UDCA were investigated. All animals showed colitis with similar severity and histologic as well as immunophenotypic alterations, resembling those of human colitis. Among the animals fed the nonsupplemented diet, 46% developed colorectal adenocarcinomas and 54% anal-rectal squamous cell carcinomas.

The prevalence of dysplasia and carcinomas did not change significantly in the animals given CA. Among the mice fed with UDCA, none developed adenocarcinomas and 20% squamous carcinomas. Dysplastic lesions were found in 88%, 67% and 40% of each group, respectively. The prevalence of dysplasia as well as of carcinoma showed an inverse relationship to the UDCA concentration in the fecal water. These data indicate that UDCA suppresses colitis-associated carcinogenesis. This model is suitable for investigation of the mechanism of the anticarcinogenic effect of UDCA in vivo. PMID: 16385573.Best regards,Dave (father of (23); PSC 07/03; UC 08/03)>> What is

cholic acid? It prevents liver injury?