Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 -----Original Message----- So, in your opinion- what are the chances of her having " Cholangitis " with out the " Primary Sclerosing " part? “There are several conditions that may trigger an infection in the bile duct system. The primary cause of cholangitis is an obstruction or blockage somewhere in the bile duct system. The blockage may be from stones, a tumor, blood clots, a narrowing that may occur after a surgical procedure, swelling of the pancreas, or from parasite invasion. Other causes include a backflow of bacteria from the small intestine, a blood infection (bacteriemia), or following a diagnostic procedure such as an endoscopic examination. The infection causes pressure to build-up in the bile duct system.” From: http://www.healthsystem.virginia.edu/uvahealth/adult_liver/cholang.cfm Barb in Texas - Together in the Fight.... Whatever it Takes! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 -----Original Message----- So, in your opinion- what are the chances of her having " Cholangitis " with out the " Primary Sclerosing " part? “There are several conditions that may trigger an infection in the bile duct system. The primary cause of cholangitis is an obstruction or blockage somewhere in the bile duct system. The blockage may be from stones, a tumor, blood clots, a narrowing that may occur after a surgical procedure, swelling of the pancreas, or from parasite invasion. Other causes include a backflow of bacteria from the small intestine, a blood infection (bacteriemia), or following a diagnostic procedure such as an endoscopic examination. The infection causes pressure to build-up in the bile duct system.” From: http://www.healthsystem.virginia.edu/uvahealth/adult_liver/cholang.cfm Barb in Texas - Together in the Fight.... Whatever it Takes! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 -----Original Message----- So, in your opinion- what are the chances of her having " Cholangitis " with out the " Primary Sclerosing " part? “There are several conditions that may trigger an infection in the bile duct system. The primary cause of cholangitis is an obstruction or blockage somewhere in the bile duct system. The blockage may be from stones, a tumor, blood clots, a narrowing that may occur after a surgical procedure, swelling of the pancreas, or from parasite invasion. Other causes include a backflow of bacteria from the small intestine, a blood infection (bacteriemia), or following a diagnostic procedure such as an endoscopic examination. The infection causes pressure to build-up in the bile duct system.” From: http://www.healthsystem.virginia.edu/uvahealth/adult_liver/cholang.cfm Barb in Texas - Together in the Fight.... Whatever it Takes! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 I have a cousin with Crohn's, another cousin with ulcerative colitis, and an aunt through marriage (no blood relation) who has UC & PSC. Yeah, what are the odds of that???As to my cousins, that's not surprising, since these diseases are all genetic, including PSC (see Tom Karlsen's research).Marie To: From: jeannie@...Date: Mon, 14 Jul 2008 15:16:31 +0000Subject: What are the chances? My husband's first cousin has Crohn's (he has Indeterminate Colitis & PSC). She has been in a particularly active spell of Crohn's lately and was being treated with Steroids. After 3 weeks on steroids, out of the blue she started having symptoms of what seemed to us like a Cholangitis Attack (fever, chills, pain in URQ, etc.) My husband and I encouraged her family to take her to the hospital or to see a different GI. The symptoms continued and they finally took her to the ER with a 104 deg fever. She was admitted and has been told she has Cholangitis. They can't do an ERCP right now due to the inflamed state of things. (I am trying to encourage them to pursue a MRCP in the mean time) So, in your opinion- what are the chances of her having "Cholangitis" with out the "Primary Sclerosing" part? Especially when a family member already has PSC? Anyone on the board have family members with similar diseases/symptoms? I know that Auto-immune disease can be hereditary; my husband has several cousins with different auto- immunes. I am specifically curious about IBD (Crohn's, IC, UC) and PSC. I am not sure what I hope to gain by asking these question. (Understanding, maybe?) I am just in complete shock that she is in this position. All the feelings I had when my husband was diagnosed are coming flooding back. I hope and pray that the Cholangitis is a freak thing for her, but I keep coming back to "what are the chances?" Thanks for your help, advice & support! It means the world to me! Jeannie Denney wife to Nick expectant mommy to baby Ethan- due in 8 weeks! Making the world a better place one message at a time. Check out the i'm Talkathon. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 My daughter has PSC/AIH/UC and my mom has PBC, coincidence have no idead.Get the scoop on last night's hottest shows and the live music scene in your area - Check out TourTracker.com! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 My daughter has PSC/AIH/UC and my mom has PBC, coincidence have no idead.Get the scoop on last night's hottest shows and the live music scene in your area - Check out TourTracker.com! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 My daughter has PSC/AIH/UC and my mom has PBC, coincidence have no idead.Get the scoop on last night's hottest shows and the live music scene in your area - Check out TourTracker.com! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 Jeannie, There definitely seems to be a hereditary connection as both my mother first had psc and UC and 3 years ago had a transplant. I was diagnosed also with psc and UC a few years before her transplant. It made a much easier diagnosis for me as I had doctors check for PSC first. My sister has IBD also. It has been very helpful to me to have my mothers experience to draw information from. Kim Townsend( Maine) Subject: What are the chances?To: Date: Monday, July 14, 2008, 3:16 PM My husband's first cousin has Crohn's (he has Indeterminate Colitis & PSC). She has been in a particularly active spell of Crohn's lately and was being treated with Steroids. After 3 weeks on steroids, out of the blue she started having symptoms of what seemed to us like a Cholangitis Attack (fever, chills, pain in URQ, etc.) My husband and I encouraged her family to take her to the hospital or to see a different GI. The symptoms continued and they finally took her to the ER with a 104 deg fever. She was admitted and has been told she has Cholangitis. They can't do an ERCP right now due to the inflamed state of things. (I am trying to encourage them to pursue a MRCP in the mean time)So, in your opinion- what are the chances of her having "Cholangitis" with out the "Primary Sclerosing" part? Especially when a family member already has PSC? Anyone on the board have family members with similar diseases/symptoms? I know that Auto-immune disease can be hereditary; my husband has several cousins with different auto-immunes. I am specifically curious about IBD (Crohn's, IC, UC) and PSC. I am not sure what I hope to gain by asking these question. (Understanding, maybe?) I am just in complete shock that she is in this position. All the feelings I had when my husband was diagnosed are coming flooding back. I hope and pray that the Cholangitis is a freak thing for her, but I keep coming back to "what are the chances?"Thanks for your help, advice & support! It means the world to me!Jeannie Denneywife to Nickexpectant mommy to baby Ethan- due in 8 weeks! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 In our immediate family, we have with UC and PSC; my mother (his grandmother) with UC. And don't laugh... and it's true... my sister's cat has UC and has been on Prednisone for 3 years. The poor kitty gets the Prednisone in a "transdermal cream" daily - so that I too can give her her meds! In addition to weight gain, Wexler the cat also has no hair on her ears from the Prednisone - her ears are translucent. We have also wondered at the number of autoimmune diseases in our block (my mom and sister live "farther away" - 3 blocks!). Within a few houses, we have dermatomyositis, multiple sclerosis, insulin dependent diabetes and rheumatoid arthritis. Genes, environment, and??? Joanne H (, Ca., mom of , 18, UC/PSC 2-06; JRA 98) I have a cousin with Crohn's, another cousin with ulcerative colitis, and an aunt through marriage (no blood relation) who has UC & PSC. Yeah, what are the odds of that???As to my cousins, that's not surprising, since these diseases are all genetic, including PSC (see Tom Karlsen's research). Marie .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 In our immediate family, we have with UC and PSC; my mother (his grandmother) with UC. And don't laugh... and it's true... my sister's cat has UC and has been on Prednisone for 3 years. The poor kitty gets the Prednisone in a "transdermal cream" daily - so that I too can give her her meds! In addition to weight gain, Wexler the cat also has no hair on her ears from the Prednisone - her ears are translucent. We have also wondered at the number of autoimmune diseases in our block (my mom and sister live "farther away" - 3 blocks!). Within a few houses, we have dermatomyositis, multiple sclerosis, insulin dependent diabetes and rheumatoid arthritis. Genes, environment, and??? Joanne H (, Ca., mom of , 18, UC/PSC 2-06; JRA 98) I have a cousin with Crohn's, another cousin with ulcerative colitis, and an aunt through marriage (no blood relation) who has UC & PSC. Yeah, what are the odds of that???As to my cousins, that's not surprising, since these diseases are all genetic, including PSC (see Tom Karlsen's research). Marie .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 14, 2008 Report Share Posted July 14, 2008 In our immediate family, we have with UC and PSC; my mother (his grandmother) with UC. And don't laugh... and it's true... my sister's cat has UC and has been on Prednisone for 3 years. The poor kitty gets the Prednisone in a "transdermal cream" daily - so that I too can give her her meds! In addition to weight gain, Wexler the cat also has no hair on her ears from the Prednisone - her ears are translucent. We have also wondered at the number of autoimmune diseases in our block (my mom and sister live "farther away" - 3 blocks!). Within a few houses, we have dermatomyositis, multiple sclerosis, insulin dependent diabetes and rheumatoid arthritis. Genes, environment, and??? Joanne H (, Ca., mom of , 18, UC/PSC 2-06; JRA 98) I have a cousin with Crohn's, another cousin with ulcerative colitis, and an aunt through marriage (no blood relation) who has UC & PSC. Yeah, what are the odds of that???As to my cousins, that's not surprising, since these diseases are all genetic, including PSC (see Tom Karlsen's research). Marie .. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 2008 Report Share Posted July 15, 2008 In my family you can see the genetic connection----in order of diagnosis-- Mom UC 1975 Me UC 1980 Mom's brother (Uncle) UC 1980s Sister UC 1999 Mom pancreatitis (possible PSC) 2005 Me pancreatitis Mar 2008 Me PSC (follow-up ERCP) May 2008 Niece (sister's daughter)has gallbladder/stomach/maybe liver issues June 2008 Don't know if uncle has PSC and and sister has not had PSC diagnosised yet. plus I did a paper on UC and Chron's for a class for my pre-reqs for nursing school and found that there is a possible genetic connection, that they do seem to be auto-immune, but that it could also be part of an allergic reaction to something in the diet, could be something from in the environment also. So this tells me that they are still not sure exactly where UC/Chrons/PSC come from completely. Beth-Thornton,CO Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 2008 Report Share Posted July 15, 2008 In my family you can see the genetic connection----in order of diagnosis-- Mom UC 1975 Me UC 1980 Mom's brother (Uncle) UC 1980s Sister UC 1999 Mom pancreatitis (possible PSC) 2005 Me pancreatitis Mar 2008 Me PSC (follow-up ERCP) May 2008 Niece (sister's daughter)has gallbladder/stomach/maybe liver issues June 2008 Don't know if uncle has PSC and and sister has not had PSC diagnosised yet. plus I did a paper on UC and Chron's for a class for my pre-reqs for nursing school and found that there is a possible genetic connection, that they do seem to be auto-immune, but that it could also be part of an allergic reaction to something in the diet, could be something from in the environment also. So this tells me that they are still not sure exactly where UC/Chrons/PSC come from completely. Beth-Thornton,CO Quote Link to comment Share on other sites More sharing options...
Guest guest Posted July 15, 2008 Report Share Posted July 15, 2008 In my family you can see the genetic connection----in order of diagnosis-- Mom UC 1975 Me UC 1980 Mom's brother (Uncle) UC 1980s Sister UC 1999 Mom pancreatitis (possible PSC) 2005 Me pancreatitis Mar 2008 Me PSC (follow-up ERCP) May 2008 Niece (sister's daughter)has gallbladder/stomach/maybe liver issues June 2008 Don't know if uncle has PSC and and sister has not had PSC diagnosised yet. plus I did a paper on UC and Chron's for a class for my pre-reqs for nursing school and found that there is a possible genetic connection, that they do seem to be auto-immune, but that it could also be part of an allergic reaction to something in the diet, could be something from in the environment also. So this tells me that they are still not sure exactly where UC/Chrons/PSC come from completely. Beth-Thornton,CO Quote Link to comment Share on other sites More sharing options...
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