The intimate relationship between gut and joint in spondyloarthropathies.

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The intimate relationship between gut and joint in spondyloarthropathies.

Spondyloarthropathies Current Opinion in Rheumatology. 19(4):353-357, July 2007.Jacques, Peggy a; Mielants, Herman a; Coppieters, Ken a; De Vos, e b; Elewaut, Dirk a

Abstract: Purpose of review: The aim of this article is to highlight recent progress in the combined joint and gut disease in spondyloarthropathies. Recent findings: A set of genes has been identified that are differentially expressed in the colon of spondyloarthropathy and Crohn's disease patients. Reduction of human leukocyte antigen B27 (HLA B27) misfolding by additional [beta]2-microglobulin in HLA B27 transgenic rats unexpectedly increased disease severity, with more similarities to spondyloarthropathies. By contrast, colitis disappeared. Summary: Human genomic studies combined with animal model research provide new clues concerning the common pathogenesis of spondyloarthropathy and Crohn's disease, further substantiating the unique relationship between gut and joint inflammation. © 2007 Lippincott & Wilkins, Inc.