Re: Interesting Study from 1994 - URSO & Varices

[Guest guest]

Barb;

The abstract you provided is the same as this one, and as I mentioned

before, this paper was RETRACTED, and therefore should not be trusted:

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Gastroenterology 102: 1389-1391 (1992)

Retraction in:

Wiesner RH, Perdigoto R. Gastroenterology. 1994 Aug;107(2):628.

Comment in:

Gastroenterology. 1994 Feb;106(2):555.

Progression of primary biliary cirrhosis with ursodeoxycholic acid

therapy.

Perdigoto R, Wiesner RH

Division of Hepatology and Gastroenterology, Mayo Clinic, Rochester,

Minnesota.

Three patients with symptomatic, noncirrhotic primary biliary

cirrhosis who had no evidence of esophageal varices on

esophagogastroduodenoscopy and who were treated with ursodeoxycholic

acid, 15 mg.kg-1.day-1, for a period of 1-2 years are reported.

Initially, all three patients showed improvement in symptoms of

fatigue and pruritus, and there was marked improvement or

normalization in serum levels of bilirubin, alkaline phosphatase, and

alanine aminotransferase. However, after 1-2 years, all three

patients progressed histologically to cirrhosis on follow-up liver

biopsy, and all had esophageal variceal bleeding documented by

esophagogastroduodenoscopy. These three patients represent examples

of ursodeoxycholic acid treatment failure despite improvements in

symptoms and biochemical liver test results. PMID: 1551544.

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Best regards,

Dave R.