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Quantell gets vitamin K shots based on the results of is PT/PTT. When

clotting times get too prolonged, that signals a deficiency of K.

Pam

(mom to Quantell, 18, dx 1996, tx 2001, dx recurrence with AIH overlap

2006)

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Quantell gets vitamin K shots based on the results of is PT/PTT. When

clotting times get too prolonged, that signals a deficiency of K.

Pam

(mom to Quantell, 18, dx 1996, tx 2001, dx recurrence with AIH overlap

2006)

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Hi Martha;

I can recommend these articles:

Alnounou M, Munoz SJ 2006 Nutrition Issues In Gastroenterology, Series #37. Nutrition concerns of the patient with primary biliary cirrhosis or primary sclerosing cholangitis. Practical Gastroenterology April 2006: 92-100.

http://www.healthsystem.virginia.edu/internet/digestive-health/nutritionarticles/April2006.pdf

Cullen SN, Rust C, Fleming K, C, Beuers U, Chapman RW 2008 High dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis is safe and effective? J. Hepatol. 48: 792-800. http://www.ncbi.nlm.nih.gov/pubmed/18314215

Harnois DM, Angulo P, nsen RA, LaRusso NF, Lindor KD 2001 High-dose ursodeoxycholic acid as a therapy for patients with primary sclerosing cholangitis. Am. J. Gastroenterol. 96: 1558-1562. http://www.ncbi.nlm.nih.gov/pubmed/11374699

SA, Bansi DS, Hunt N, Von Bergmann K, Fleming KA, Chapman RW 2001 A preliminary trial of high-dose ursodeoxycholic acid in primary sclerosing cholangitis. Gastroenterology 121: 900-907. http://www.ncbi.nlm.nih.gov/pubmed/11606503

Rost D, Rudolph G, Kloeters-Plachky P, Stiehl A 2004 Effect of high-dose ursodeoxycholic acid on its biliary enrichment in primary sclerosing cholangitis. Hepatology 40: 693-698.http://www.ncbi.nlm.nih.gov/pubmed/15349909

The first article in the list deals with nutrient deficiencies in PBC and PSC patients, including vitamin A, D, E and K deficiencies.

It sounds like Matt is currently on a dose of about 17.8 mg/kg/day of urso, and some of the above papers suggest that 25 - 30 mg/kg/d may be more effective.

Best regards,

Dave

(father of (22); PSC 07/03; UC 08/03)

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