Re: More on Intestinal Alkaline Phosphatase and Lipopolysaccharide

[Guest guest]

Hi Nina;

The intestinal alkaline phosphatase is produced in the intestines,

where it is secreted into the gut, and de-phosphorylates

lipopolysaccharide, protecting against sepsis.

Goldberg RF, Austen WG Jr, Zhang X, Munene G, Mostafa G, Biswas S,

McCormack M, Eberlin KR, Nguyen JT, Tatlidede HS, Warren HS, Narisawa

S, Millán JL, Hodin RA 2008 Intestinal alkaline phosphatase is a gut

mucosal defense factor maintained by enteral nutrition. Proc Natl

Acad Sci U S A. 105(9):3551-3556.

http://www.ncbi.nlm.nih.gov/pubmed/18292227

This is not the same enzyme that is produced in the liver and that is

elevated in response to bile duct injury or blockage, and which shows

up in the serum as elevated ALP in your blood tests.

There is also a " bone " alkaline phosphatase. The intestinal, liver

and bone ALPs are called isozymes:

http://www.nlm.nih.gov/medlineplus/ency/article/003497.htm

I'm interested in the intestinal alkaline phosphatase because it " has

the ability to detoxify lipopolysaccharide and prevent bacterial

invasion across the gut mucosal barrier " . This is one of the main

problems in PSC:

Cullen S, Chapman R 2001 Aetiopathogenesis of primary sclerosing

cholangitis. Best Pract. Res. Clin. Gastroenterol. 15: 577-589.

http://www.ncbi.nlm.nih.gov/pubmed/11492969

" PSC may be triggered in genetically susceptible individuals by toxic

or infectious agents gaining access to the liver via a diseased and

permeable colon. "

Best regards,

Dave

(father of (22); PSC 07/03; UC 08/03)

>

> This was a little confusing to me; is this the same Alk-Phos that

gets

> tested in the regular liver panels? Don't we want lower Alk Phos

> numbers? tx,

>

> Nina in Philly